Molecular structure of Ursolic Acid, CAS Number: 77-52-1
Ursolic Acid (CAS 77-52-1)
See product citations (8)
Application:
Ursolic Acid is an antiangiogenic and antiproliferative agent
CAS Number:
77-52-1
Purity:
≥95%
Molecular Weight:
456.7
Molecular Formula:
C30H48O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ursolic Acid, a naturally occurring triterpenoid, has been noted to demonstrate anti-angiogenic and anti-proliferative properties. Mechanistic studies suggest that this compound down-regulates MMP-2 and uPA expression in cells via inhibition of Akt, JNK, mammalian target of Rapamycin (sc-3504) phosphorylation, and levels of NFkappaB protein in the nucleus. Other experiments have shown that Ursolic Acid may improve blood glucose, glucose tolerance, insulin tolerance, glycosylated hemoglobin, and plasma leptin levels in diabetic murine models. Additionally, this agent displays a capacity to induce cell cycle arrest and apoptosis through activation of p53 pathway and Bax protein, as well as down-regulation of Bcl-2.
Ursolic Acid (CAS 77-52-1) References
- Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling. | Yeh, CT., et al. 2010. Mol Nutr Food Res. 54: 1285-95. PMID: 20352621
- Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway. | Yu, YX., et al. 2010. Chin Med J (Engl). 123: 1915-23. PMID: 20819578
- Ursolic acid ameliorates thymic atrophy and hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice. | Lee, J., et al. 2010. Chem Biol Interact. 188: 635-42. PMID: 20869956
- Ursolic acid, a potential anticancer compound for breast cancer therapy. | Yin, R., et al. 2018. Crit Rev Food Sci Nutr. 58: 568-574. PMID: 27469428
- Ursolic acid and mechanisms of actions on adipose and muscle tissue: a systematic review. | Katashima, CK., et al. 2017. Obes Rev. 18: 700-711. PMID: 28335087
- Ursolic acid: An overview on its cytotoxic activities against breast and colorectal cancer cells. | Chan, EWC., et al. 2019. J Integr Med. 17: 155-160. PMID: 30928277
- Ursolic Acid and Its Derivatives as Bioactive Agents. | Mlala, S., et al. 2019. Molecules. 24: PMID: 31362424
- Rosmarinic acid and ursolic acid alleviate deficits in cognition, synaptic regulation and adult hippocampal neurogenesis in an Aβ1-42-induced mouse model of Alzheimer's disease. | Mirza, FJ., et al. 2021. Phytomedicine. 83: 153490. PMID: 33601255
- Beneficial Effects of Ursolic Acid and Its Derivatives-Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions. | Erdmann, J., et al. 2021. Nutrients. 13: PMID: 34836155
- Ursolic acid ameliorates amyloid β-induced pathological symptoms in Caenorhabditis elegans by activating the proteasome. | Wang, N., et al. 2022. Neurotoxicology. 88: 231-240. PMID: 34902447
- Ursolic acid enhances the antitumor effects of sorafenib associated with Mcl-1-related apoptosis and SLC7A11-dependent ferroptosis in human cancer. | Li, H., et al. 2022. Pharmacol Res. 182: 106306. PMID: 35714823
- Anti-angiogenic activity of triterpene acids. | Sohn, KH., et al. 1995. Cancer Lett. 94: 213-8. PMID: 7543366
Inhibitor of:
α-Amylase, from pig pancreas, 14-3-3 σ, Angiogenesis, APOBEC3B, c-Jun, CBP β, CCL12, colipase, Coronavirus nucleocapsid, CXorf49B, CYLC1, DHRS7B, DUSP4, ephrin-B3, Esp18, FOXD4L2-6, GPD2, H2-Dk, HSP 47, IER3IP1, Integrin α4β7, ITF, Ivl, LOXL1, LRP3, MOSC2, Msx-2, MYLK, NCoA-3, NFKBIL1, NGAL, nPKC η, PATE3, PCNA, PCSK9, Pez, PGK2, Pot1b, PSG11, Psg19, Psg21, Psg23, Psg25, Psg26, Psg27, Psg28, PSGL-1, PTTG, QSK, Reg IIIβ, resistin, sFlt-1, SLP-76, SMUG1, SnoN_SnoN2_SnoA, Spi-B, Sprouty 2, SR-A, Syndecan-2, T6BP, TC-PTP, TERT, TLR5, TMPRSS11C, TMPRSS11E2, TNF-R2, TRAF2, Trav9n-3, V1RC24, V1RC32, V1rc5, V1RF1, V1RF4, WISP-2, and Wnt-10b.Activator of:
α-Amylase, from pig pancreas, ADAM9, apoE, atrophin-1, B7-2, B7-H3, BRD2, C030014O09Rik, cathepsin M, CD1D, CPV CrmA, cryptdin 3, Cyp2c69, CYP2T4, DNA pol δ 4, DNA pol δ ss, DNAL4, DNER, DUSP5, EG240327, EG243302, EG434396, Elastase-3B, ENX-1, FAF1, FBXW22, Fn14, Glut6, GPR87, IκB-δ, IL-18BP, IL-27, Integrin β1, ITI-H1, Jun D, KLRF2, LMP7, MALT1, MRP7, Myt 1, NF-E2, NQO1, Nrf2, Nrf3, OTTMUSG00000018260, PD-L2, PDC-E2, PIG-M, PINK1, Proteassemblin, PSR, Rab 28, Rb, Reg IIIβ, Reg lllα, REG3α, RORβ, SETX, SOD-2, TMC5, TMPRSS11D, TMPRSS2, TRAF4, TRIM30C, TRIM35, USP5, Vitronectin, WDR40A, ZNF189, and ZNF79.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ursolic Acid, 50 mg | sc-200383 | 50 mg | $55.00 | |||
Ursolic Acid, 250 mg | sc-200383A | 250 mg | $176.00 |