Date published: 2026-4-14

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Tris(hydroxymethyl)nitromethane (CAS 126-11-4)

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Alternate Names:
2-Hydroxymethyl-2-nitro-1,3-propanediol
CAS Number:
126-11-4
Molecular Weight:
151.12
Molecular Formula:
C4H9NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tris(hydroxymethyl)nitromethane, also known as THNM, is a strong oxidizing agent used for a variety of purposes, including the synthesis of other compounds, as a reagent in organic synthesis, and as a catalyst in various reactions. In addition, Tris(hydroxymethyl)nitromethane is also used in biochemical and physiological studies. Research has shown that it impacts the metabolism of carbohydrates, lipids, and proteins and stimulates the production of cytokines that regulate the immune response. Additionally, Tris(hydroxymethyl)nitromethane influences gene expression, affecting cellular development and function.


Tris(hydroxymethyl)nitromethane (CAS 126-11-4) References

  1. Formaldehyde-releasers: relationship to formaldehyde contact allergy. Part 2: Metalworking fluids and remainder.  |  de Groot, A., et al. 2010. Contact Dermatitis. 63: 129-39. PMID: 20573163
  2. Efficient synthesis of a peculiar vicinal diamine semiochemical from Streptomyces natalensis.  |  Morin, JB. and Sello, JK. 2010. Org Lett. 12: 3522-4. PMID: 20670016
  3. DNA-protein cross-links produced by various chemicals in cultured human lymphoma cells.  |  Costa, M., et al. 1997. J Toxicol Environ Health. 50: 433-49. PMID: 9140463

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tris(hydroxymethyl)nitromethane, 25 g

sc-237390
25 g
$41.00

Tris(hydroxymethyl)nitromethane, 100 g

sc-237390A
100 g
$72.00