|PRODUCT NAME||CATALOG #||UNIT||PRICE||QTY||FAVORITES|
TPEN is a cell permeable, high-affinity heavy metal (Zn2+>Fe2+>Mn2+) chelator that exhibits low affinity for Mg2+ and Ca2+. The compound is lipid-soluble and has been shown to permeate artificial and natural membranes. Research shows that TPEN induces apoptosis in human and rat thymocytes through DNA fragmentation and Caspace-3 activation. TPEN also induces mitochondrial cytochrome C translocation to the cytosol in human PBL. A recent study has proved this chelator to work in conjunction with the fluorescent probe Fura-2 (sc-202163) in biophysical studies of Ca2+.
1. Treves, S., et al. 1994. Exp. Cell Res. 211: 339-343. PMID: 8143781
2. Kolenko, V.M., et al. 2001. Apoptosis. 6: 419-429. PMID: 11595831
3. Chimienti, F., et al. 2001. Biochem. Pharmacol. 6: 51-62. PMID: 11377396
4. Matias, C.M., et al. 2010. J Fluoresc. 20: 377-380. PMID: 19821015
See how others have used TPEN. Click on the entry to view the PubMed entry .
PMID: # 26712852
Qian, C. et al. 2016. Zinc flexes its muscle: Correcting a novel analysis of calcium for zinc interference uncovers a method to measure zinc. The Journal of general physiology. 147: 95-102.
PMID: # 25032698
Kashyap, DR. et al. 2014. Peptidoglycan recognition proteins kill bacteria by inducing oxidative, thiol, and metal stress. PLoS pathogens. 10: e1004280.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2017 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.