TPEN is a cell permeable, high-affinity heavy metal (Zn2+>Fe2+>Mn2+) chelator that exhibits low affinity for Mg2+ and Ca2+. The compound is lipid-soluble and has been shown to permeate artificial and natural membranes. Research shows that TPEN induces apoptosis in human and rat thymocytes through DNA fragmentation and Caspace-3 activation. TPEN also induces mitochondrial cytochrome C translocation to the cytosol in human PBL. A recent study has proved this chelator to work in conjunction with the fluorescent probe Fura-2 (sc-202163) in biophysical studies of Ca2+.
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4. Matias, C.M., et al. 2010. J Fluoresc. 20: 377-380. PMID: 19821015
See how others have used TPEN. Click on the entry to view the PubMed entry .
PMID: # 26712852 Qian, C. et al. 2016. The Journal of general physiology. 147: 95-102.
PMID: # 25032698 Kashyap, DR. et al. 2014. PLoS pathogens. 10: e1004280.
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