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TPEN is a cell permeable, high-affinity heavy metal (Zn2+>Fe2+>Mn2+) chelator that exhibits low affinity for Mg2+ and Ca2+. The compound is lipid-soluble and has been shown to permeate artificial and natural membranes. Research shows that TPEN induces apoptosis in human and rat thymocytes through DNA fragmentation and Caspace-3 activation. TPEN also induces mitochondrial cytochrome C translocation to the cytosol in human PBL. A recent study has proved this chelator to work in conjunction with the fluorescent probe Fura-2 (sc-202163) in biophysical studies of Ca2+.
1. Treves, S., et al. 1994. Exp. Cell Res. 211: 339-343. PMID: 8143781
2. Kolenko, V.M., et al. 2001. Apoptosis. 6: 419-429. PMID: 11595831
3. Chimienti, F., et al. 2001. Biochem. Pharmacol. 6: 51-62. PMID: 11377396
4. Matias, C.M., et al. 2010. J Fluoresc. 20: 377-380. PMID: 19821015
See how others have used TPEN. Click on the entry to view the PubMed entry .
PMID: # 26712852
Qian, C. et al. 2016. Zinc flexes its muscle: Correcting a novel analysis of calcium for zinc interference uncovers a method to measure zinc. The Journal of general physiology. 147: 95-102.
PMID: # 25032698
Kashyap, DR. et al. 2014. Peptidoglycan recognition proteins kill bacteria by inducing oxidative, thiol, and metal stress. PLoS pathogens. 10: e1004280.
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