TEMPOL A superoxide dismutase mimetic that restores the effects of TNF-α

TEMPOL  (CAS 2226-96-2)

TEMPOL is rated 5.0 out of 5 by 3.
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| See 14 Citations
Synonym: 1-Oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine
Application: A superoxide dismutase mimetic that restores the effects of TNF-α
CAS Number: 2226-96-2
Purity: ≥99%
Molecular Weight: 172.25
Molecular Formula: C9H18NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
TEMPOL sc-200825 1 g $26.00

TEMPOL is a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, and has the ability to permeate the membrane. In the presence of TEMPOL, cerebral vessel remodeling is blocked and collagen IV mRNA expression levels are elevated in normotensive and hypertensive rat studies. TEMPOL has been shown to restore the oxidative stress and cardiac dysfunction induced by TNF-α and in PC-12 cells has revealed neuroprotective effects. Additionally, it has shown to decrease blood pressure and sympathetic nerve activity in DOCA-salt rat studies.


References

1. Mitchell, J.B., et al. 1991. Arch. Biochem. Biophys. 289: 62-70. PMID: 1654848
2. Xu, H., et al. 2004. Hypertension. 43: 329-334. PMID: 14707156
3. Khattab, M.M., 2006. Eur. J. Pharmacol. 548: 167-173. PMID: 16973155
4. Lipman, T., et al. 2006. Eur. J. Pharmacol. 549: 50-57. PMID: 16989807
5. Mariappan, N., et al. 2007. Am. J. Physiol. Heart Circ. Physiol. 293: H2726-H2737. PMID: 17675574
6. Pires, P.W., et al. 2010. Microvasc Res. PMID: 20600163

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water (1670 g/l) at 20° C, ethanol (100 mM), methanol, and DMSO (100 mM).
Storage :
Store at room temperature
Melting Point :
69-71° C (lit.)
Boiling Point :
269° C
Density :
1.19 g/cm3
IC50 :
Plasmodium falciparum K1: IC50 = 19 µg/ml; Plasmodium falciparum NF54: IC50 = 27 µg/ml
pK Values :
pKb: 5.15
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
TN8991000
PubChem CID :
137994
Merck Index :
14: 9141
MDL Number :
MFCD00006478
EC Number :
218-760-9
Beilstein Registry :
1422990
SMILES :
CC1(CC(CC(N1[O])(C)C)O)C

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Certificate of Analysis

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TEMPOL Product Citations

See how others have used TEMPOL. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 14 total

PMID: # 27679544
Steiner, I. et al. 2016. Discovery of 'click' 1,2,3-triazolium salts as potential anticancer drugs. Radiol Oncol. 50: 280-8.

PMID: # 27069531
Salvi, A. et al. 2016. Protective Effect of Tempol on Buthionine Sulfoximine-Induced Mitochondrial Impairment in Hippocampal Derived HT22 Cells. Oxid Med Cell Longev. 2016: 5059043.

PMID: # 27088800
Wen, Z. et al. 2016. NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs. J. Clin. Invest.. 126: 1953-67.

PMID: # 25793256
Patki, G. et al. 2015. Tempol treatment reduces anxiety-like behaviors induced by multiple anxiogenic drugs in rats. PLoS ONE. 10: e0117498.

PMID: # 25752964
Al-Shboul, O. et al. 2015. Effect of oxidative stress on Rho kinase II and smooth muscle contraction in rat stomach. Can. J. Physiol. Pharmacol.. 93: 405-11.

PMID: # 26000607
Zhang, M. et al. 2015. The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer Cells. PloS one. 10: e0127386.

PMID: # 24879153
Tiwari, M. et al. 2014. A nonapoptotic role for CASP2/caspase 2: modulation of autophagy. Autophagy. 10: 1054-70.

PMID: # 24144633
Su, Y. et al. 2013. Uncoupling of eNOS contributes to redox-sensitive leukocyte recruitment and microvascular leakage elicited by methylglyoxal. Biochem. Pharmacol.. 86: 1762-74.

PMID: # 23747723
Sun, B. et al. 2013. Bone morphogenetic protein-4 contributes to the down-regulation of Kv4.3 K+ channels in pathological cardiac hypertrophy. Biochem. Biophys. Res. Commun.. 436: 591-4.

PMID: # 24167244
Farrow, MA. et al. 2013. Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex. Proc. Natl. Acad. Sci. U.S.A.. 110: 18674-9.

Citations 1 to 10 of 14 total

Is this product cell culture grade?

Asked by: two2igm05
Thank you for your question. TEMPOL, sc-200825, is not cell culture grade.
Answered by: Chemical Support 4
Date published: 2017-04-11

What is the appearance? Is it colorless?

Asked by: chemsd02
Thank you for your question. sc-200825 (TEMPOL, CAS 2226-96-2) is an orange, flaky crystalline solid.
Answered by: Chemical Support 10
Date published: 2017-04-10

What is the long term storage of this product?

Asked by: hawkeye11
Thank you for your question. The compound, sc-200825, is stable for up to 3 years if stored as a powder at -20ºC. If the compound is made into a solution, then it is stable for up to 6 months if stored at -80ºC. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-23
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Rated 5 out of 5 by from Achieve goal! In the experiments, we found that Tempol has been restored to oxidative stress and cardiac dysfunction and TNF- alpha PC-12 cells induce neuroprotection. In addition, it has reduced blood pressure and sympathetic activity in DOCA salt rats
Date published: 2017-02-09
Rated 5 out of 5 by from be used We used in the presence of TEMPOL, cerebral vascular remodeling was blocked and the expression of collagen IV mRNA increased in normal blood pressure and hypertensive rat studies. TEMPOL has been shown to restore oxidative stress and cardiac dysfunction induced by TNF, and has been shown to be neuroprotective in PC-12 cells.
Date published: 2017-02-05
Rated 5 out of 5 by from Worked well in our experiments Worked well in our experiments, happy with purchase.
Date published: 2015-06-10
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