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TEMPOL is a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, and has the ability to permeate the membrane. In the presence of TEMPOL, cerebral vessel remodeling is blocked and collagen IV mRNA expression levels are elevated in normotensive and hypertensive rat studies. TEMPOL has been shown to restore the oxidative stress and cardiac dysfunction induced by TNF-α and in PC-12 cells has revealed neuroprotective effects. Additionally, it has shown to decrease blood pressure and sympathetic nerve activity in DOCA-salt rat studies.
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See how others have used TEMPOL. Click on the entry to view the PubMed entry .
PMID: # 27679544
Steiner, I. et al. 2016. Discovery of 'click' 1,2,3-triazolium salts as potential anticancer drugs. Radiol Oncol. 50: 280-8.
PMID: # 27069531
Salvi, A. et al. 2016. Protective Effect of Tempol on Buthionine Sulfoximine-Induced Mitochondrial Impairment in Hippocampal Derived HT22 Cells. Oxid Med Cell Longev. 2016: 5059043.
PMID: # 27088800
Wen, Z. et al. 2016. NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs. J. Clin. Invest.. 126: 1953-67.
PMID: # 25793256
Patki, G. et al. 2015. Tempol treatment reduces anxiety-like behaviors induced by multiple anxiogenic drugs in rats. PLoS ONE. 10: e0117498.
PMID: # 25752964
Al-Shboul, O. et al. 2015. Effect of oxidative stress on Rho kinase II and smooth muscle contraction in rat stomach. Can. J. Physiol. Pharmacol.. 93: 405-11.
PMID: # 26000607
Zhang, M. et al. 2015. The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer Cells. PloS one. 10: e0127386.
PMID: # 24879153
Tiwari, M. et al. 2014. A nonapoptotic role for CASP2/caspase 2: modulation of autophagy. Autophagy. 10: 1054-70.
PMID: # 24144633
Su, Y. et al. 2013. Uncoupling of eNOS contributes to redox-sensitive leukocyte recruitment and microvascular leakage elicited by methylglyoxal. Biochem. Pharmacol.. 86: 1762-74.
PMID: # 23747723
Sun, B. et al. 2013. Bone morphogenetic protein-4 contributes to the down-regulation of Kv4.3 K+ channels in pathological cardiac hypertrophy. Biochem. Biophys. Res. Commun.. 436: 591-4.
PMID: # 24167244
Farrow, MA. et al. 2013. Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex. Proc. Natl. Acad. Sci. U.S.A.. 110: 18674-9.
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