Date published: 2025-10-14
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TEMPOL (CAS 2226-96-2) - chemical structure image
Molecular structure of TEMPOL, CAS Number: 2226-96-2
TEMPOL (CAS 2226-96-2) - chemical structure image
Molecular structure of TEMPOL, CAS Number: 2226-96-2
Molecular structure of TEMPOL, CAS Number: 2226-96-2

TEMPOL (CAS 2226-96-2)

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See product citations (33)

Alternate Names:
4-OH-TEMPO;4-Hydroxy-TEMPO;4-Hydroxy-2,2,6,6-tetramethylpiperidinyloxy, free radical
Application:
TEMPOL is a superoxide dismutase mimetic that restores the effects of TNF-α
CAS Number:
2226-96-2
Purity:
≥99%
Molecular Weight:
172.25
Molecular Formula:
C9H18NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

TEMPOL is a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, and has the ability to permeate the membrane. In the presence of TEMPOL, cerebral vessel remodeling is blocked and collagen IV mRNA expression levels are elevated in normotensive and hypertensive rat studies. TEMPOL may act to restore the oxidative stress and cardiac dysfunction induced by TNF-alpha and in PC-12 cells has revealed neuroprotective effects. Additionally, it has shown to decrease blood pressure and sympathetic nerve activity in DOCA-salt rat studies.


TEMPOL (CAS 2226-96-2) References

  1. Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats.  |  Xu, H., et al. 2004. Hypertension. 43: 329-34. PMID: 14707156
  2. Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol.  |  Mitchell, JB., et al. 1991. Arch Biochem Biophys. 289: 62-70. PMID: 1654848
  3. TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion.  |  Khattab, MM. 2006. Eur J Pharmacol. 548: 167-73. PMID: 16973155
  4. Neuroprotective effects of the stable nitroxide compound Tempol on 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in the Nerve Growth Factor-differentiated model of pheochromocytoma PC12 cells.  |  Lipman, T., et al. 2006. Eur J Pharmacol. 549: 50-7. PMID: 16989807
  5. TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic Tempol.  |  Mariappan, N., et al. 2007. Am J Physiol Heart Circ Physiol. 293: H2726-37. PMID: 17675574
  6. Tempol, a superoxide dismutase mimetic, prevents cerebral vessel remodeling in hypertensive rats.  |  Pires, PW., et al. 2010. Microvasc Res. 80: 445-52. PMID: 20600163
  7. Tempol prevents chronic sleep-deprivation induced memory impairment.  |  Alzoubi, KH., et al. 2016. Brain Res Bull. 120: 144-50. PMID: 26616531
  8. Tempol prevents post-traumatic stress disorder induced memory impairment.  |  Alzoubi, KH., et al. 2018. Physiol Behav. 184: 189-195. PMID: 29217357
  9. Tempol improves oxidant/antioxidant parameters in testicular tissues of diabetic rats.  |  Shateri, H., et al. 2019. Life Sci. 221: 65-71. PMID: 30738867
  10. Tempol treatment shows phenotype improvement in mdx mice.  |  Hermes, TA., et al. 2019. PLoS One. 14: e0215590. PMID: 31009514
  11. Tempol improves redox status in mdx dystrophic diaphragm muscle.  |  Hermes, TA., et al. 2020. Int J Exp Pathol. 101: 289-297. PMID: 33098599
  12. Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction.  |  Li, T., et al. 2021. Redox Biol. 41: 101886. PMID: 33592539
  13. The antioxidant tempol transforms gut microbiome to resist obesity in female C3H mice fed a high fat diet.  |  Choudhuri, R., et al. 2022. Free Radic Biol Med. 178: 380-390. PMID: 34883252
  14. Effect of tempol and straw size on rooster sperm quality and fertility after post-thawing.  |  Najafi, A., et al. 2022. Sci Rep. 12: 12192. PMID: 35842559
  15. Tempol Inhibits the Growth of Lung Cancer and Normal Cells through Apoptosis Accompanied by Increased O2•- Levels and Glutathione Depletion.  |  Park, WH. 2022. Molecules. 27: PMID: 36364165

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

TEMPOL, 1 g

sc-200825
1 g
$36.00

Is this product cell culture grade?

Asked by: two2igm05
Thank you for your question. TEMPOL, sc-200825, is not cell culture grade.
Answered by: Chemical Support 4
Date published: 2017-04-11

What is the appearance? Is it colorless?

Asked by: chemsd02
Thank you for your question. sc-200825 (TEMPOL, CAS 2226-96-2) is an orange, flaky crystalline solid.
Answered by: Chemical Support 10
Date published: 2017-04-10

What is the long term storage of this product?

Asked by: hawkeye11
Thank you for your question. The compound, sc-200825, is stable for up to 3 years if stored as a powder at -20ºC. If the compound is made into a solution, then it is stable for up to 6 months if stored at -80ºC. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-23
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Rated 5 out of 5 by from Achieve goal!In the experiments, we found that Tempol has been restored to oxidative stress and cardiac dysfunction and TNF- alpha PC-12 cells induce neuroprotection. In addition, it has reduced blood pressure and sympathetic activity in DOCA salt rats
Date published: 2017-02-09
Rated 5 out of 5 by from be usedWe used in the presence of TEMPOL, cerebral vascular remodeling was blocked and the expression of collagen IV mRNA increased in normal blood pressure and hypertensive rat studies. TEMPOL has been shown to restore oxidative stress and cardiac dysfunction induced by TNF, and has been shown to be neuroprotective in PC-12 cells.
Date published: 2017-02-05
Rated 5 out of 5 by from Worked well in our experimentsWorked well in our experiments, happy with purchase.
Date published: 2015-06-10
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TEMPOL is rated 5.0 out of 5 by 3.
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