Molecular structure of Telomerase Inhibitor IX, CAS Number: 368449-04-1
Telomerase Inhibitor IX (CAS 368449-04-1)
See product citations (2)
Alternate Names:
MST-312; N,N′-bis(2,3-Dihydroxybenzoyl)-1,3-phenylenediamine
Application:
Telomerase Inhibitor IX is a potent, reversible inhibitor of telomerase activity
CAS Number:
368449-04-1
Purity:
≥95%
Molecular Weight:
380.36
Molecular Formula:
C20H16N2O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Telomerase Inhibitor IX, also called MST-312, is a synthetic compound that acts as a reversible TERT (telomerase) inhibitor, and is described to be more potent than epigallocatechin gallate (sc-200802). UP37 cell studies suggest that in the presence of Telomerase Inhibitor IX, cell growth slows and the cells remain in the G0-G1 cell cycle arrest. In addition, reports indicate that Telomerase Inhibitor IX does not inhibit Taq DNA polymerase (sc-43501).
Telomerase Inhibitor IX (CAS 368449-04-1) References
- Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295, and MST-1991. | Seimiya, H., et al. 2002. Mol Cancer Ther. 1: 657-65. PMID: 12479362
- Low telomerase activity: possible role in the progression of human medullary thyroid carcinoma. | Stadler, G., et al. 2008. Eur J Cancer. 44: 866-75. PMID: 18296042
- Evaluation of tankyrase inhibition in whole cells. | Ohishi, T., et al. 2007. Methods Mol Biol. 405: 133-46. PMID: 18369822
- Telomerase inhibition as a novel therapy for pediatric ependymoma. | Wong, VC., et al. 2010. Brain Pathol. 20: 780-6. PMID: 20184588
- DNAzyme-like activity of hemin-telomeric G-quadruplexes for the optical analysis of telomerase and its inhibitors. | Freeman, R., et al. 2010. Chembiochem. 11: 2362-7. PMID: 21031400
- Microenvironmental regulation of telomerase isoforms in human embryonic stem cells. | Radan, L., et al. 2014. Stem Cells Dev. 23: 2046-66. PMID: 24749509
- Combination treatment with flavonoid morin and telomerase inhibitor MST‑312 reduces cancer stem cell traits by targeting STAT3 and telomerase. | Chung, SS., et al. 2016. Int J Oncol. 49: 487-98. PMID: 27279256
- Salinomycin Abolished STAT3 and STAT1 Interactions and Reduced Telomerase Activity in Colorectal Cancer Cells. | Chung, SS., et al. 2017. Anticancer Res. 37: 445-453. PMID: 28179289
- Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma. | Liang, WS., et al. 2017. Genome Res. 27: 524-532. PMID: 28373299
- High BMI1 Expression with Low CD8+ and CD4+ T Cell Activity Could Promote Breast Cancer Cell Survival: A Machine Learning Approach. | Chung, Y., et al. 2021. J Pers Med. 11: PMID: 34442383
- Drug Repositioning Identifies Six Drug Candidates for Systemic Autoimmune Diseases by Integrative Analyses of Transcriptomes from Scleroderma, Systemic Lupus Erythematosus, and Sjogren's Syndrome. | Oktem, EK. and Yazar, M. 2022. OMICS. 26: 683-693. PMID: 36378860
- Integrated analysis of diagnostic, prognostic value and potential drug treatment of GSDME in head and neck squamous cell carcinoma. | Hu, R., et al. 2023. Eur Arch Otorhinolaryngol.. PMID: 37204444
- Inhibition Of Telomerase Is a Novel and Effective Therapy In MLL-Rearranged Acute Myeloid Leukemia (AML) | Bruedigam, C., Bagger, F. O., Kuhn, C. P., Vu, T., Austin, R., Heidel, F. H.,.. & Lane, S. W. 2013. Blood. 122(21): 2887.
Inhibitor of:
Est1, PINX1, RTEL1, Spt7, Tel1, TEN1, TERT, TP1, TRF1, TRF2, and TRT.Activator of:
TIN2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Telomerase Inhibitor IX, 10 mg | sc-204333 | 10 mg | $200.00 |