Streptomycin sulfate An antibiotic for cell culture

Streptomycin sulfate (CAS 3810-74-0)

Streptomycin sulfate | CAS 3810-74-0 is rated 5.0 out of 5 by 1.
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Application: An antibiotic for cell culture
CAS Number: 3810-74-0
Molecular Weight: 1457.38
Molecular Formula: (C21H39N7O12)23H2SO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Streptomycin sulfate is an aminocyclitol glycoside antibiotic which interferes with protein synthesis in prokaryotes. This antibiotic is effective against both gram-positive and gram-negative bacteria and is frequently used in cell culture media. Streptomycin inhibits protein synthesis by binding to the 30S ribosomal subunit at the S12 protein thereby inducing a misreading of the genetic code, inhibiting the initiation of translation of DNA which then results in death for a susceptible bacterium.


References

1. Luzzatto, L., et al. 1968. Proc. Natl. Acad. Sci. U.S.A. 60: 873-880. PMID: 4875806
2. Sander, P., et al. 1996. Res. Microbiol. 147: 59-67. PMID: 8761724
3. Sharma, D., et al. 2007. J. Mol. Biol. 374: 1065-1076. PMID: 17967466

Appearance :
Powder
Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in water (50 mg/ml).
Storage :
Store at -20° C
Optical Activity :
α20/D -83.5°±4.5°, c = 1 in water
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
WK4990000
PubChem CID :
6419957
Merck Index :
14: 8826
MDL Number :
MFCD00037023
EC Number :
223-286-0
Beilstein Registry :
3894995
SMILES :
C[C@H]1[C@@]([C@H]([C@@H](O1)O[C@H]2[C@@H]([C@H]([C@@H]([C@H]([C@@H]2O)O)N=C(N)N)O)N=C(N)N)O[C@H]3[C@H]([C@@H]([C@H]([C@@H](O3)CO)O)O)NC)(C=O)O.C[C@H]1[C@@]([C@H]([C@@H](O1)O[C@H]2[C@@H]([C@H]([C@@H]([C@H]([C@@H]2O)O)N=C(N)N)O)N=C(N)N)O[C@H]3[C@H]([C@@H]([C@H]([C@@H](O3)CO)O)O)NC)(C=O)O.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O

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Streptomycin sulfate  Product Citations

See how others have used Streptomycin sulfate. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 28904402  Falone, S. et al. 2017. Sci Rep. 7: 11470.

PMID: # 28116035  Falone, S. et al. 2016. Oxid Med Cell Longev. 2016: 3837623.

PMID: # 27350089  Zhang, N. et al. 2016. Oncol. Rep. 36: 977-83.

PMID: # 23325617  Liu, D. et al. 2013. Tumour Biol. 34: 1131-8.

PMID: # 23526078  Zhan, B. et al. 2013. Tumour Biol. 34: 1759-66.

PMID: # 22741553  Harvey, CJ. et al. 2012. J. Am. Chem. Soc. 134: 12259-65.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from Many articles reported the usage of Streptomycin Many articles reported the usage of Streptomycin sulfate as an antibiotic treatment in tissue culture media. -SCBT Publication Review
Date published: 2015-05-24
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