Date published: 2025-9-19

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Sodium Stearyl Fumarate (CAS 4070-80-8)

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Alternate Names:
Fumaric Acid Octadecyl Ester Sodium Salt; Sodium Octadecyl Fumarate
CAS Number:
4070-80-8
Molecular Weight:
390.53
Molecular Formula:
C22H39NaO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sodium stearyl fumarate, cataloged under CAS number 4070-80-8, is a sodium salt of stearyl fumaric acid, characterized by its application as a lubricant in various non-medical industries, particularly in food and cosmetics manufacturing. This compound is structurally unique due to the presence of a long stearyl chain and a fumarate group, which confer specific physicochemical properties such as hydrophobicity and an ability to interact with other molecular entities through non-covalent forces. In research contexts, sodium stearyl fumarate is often explored for its role in modifying the texture and stability of products. It acts by creating a barrier on the surface of particles, which can prevent adhesion and improve the free flow of powders, a property highly valued in the processing of powdered foods and in the production of personal care products. Furthermore, its efficacy as a lubricant allows for its use in studying the mechanics of solid-solid interactions in particulate systems. Researchers utilize this compound to understand and optimize the manufacturing processes where control over particle flow and reduction of friction are necessary. Additionally, sodium stearyl fumarate′s compatibility with various substances makes it a subject of study in the development of environmentally friendly lubricants and stabilizers that can perform effectively under a broad range of conditions.


Sodium Stearyl Fumarate (CAS 4070-80-8) References

  1. Influence of emulsifier structure on lipid bioaccessibility in oil-water nanoemulsions.  |  Speranza, A., et al. 2013. J Agric Food Chem. 61: 6505-15. PMID: 23758276
  2. Degradation caused by incompatibility between sodium stearyl fumarate (PRUV) and AZD7986 in the drug product.  |  Ludvigsson, JW., et al. 2018. J Pharm Biomed Anal. 158: 82-87. PMID: 29860182
  3. Application of a quality-by-design approach for utilizing sodium stearyl fumarate as a taste-masking agent in dextromethorphan hydrobromide orally disintegrating tablets.  |  Mahrous, GM., et al. 2019. Pharm Dev Technol. 24: 711-719. PMID: 30714850
  4. Investigation of Solid Dosage Form Components Interaction Using Orthogonal Techniques- Discovery of New Forms of Sodium Stearyl Fumarate.  |  Shrestha, M., et al. 2021. J Pharm Sci. 110: 1592-1600. PMID: 33465337
  5. Investigating the Influence of Excipients on the Stability of Levothyroxine Sodium Pentahydrate.  |  Kaur, N. and Suryanarayanan, R. 2021. Mol Pharm. 18: 2683-2693. PMID: 34061524
  6. Prediction of the impact of lubrication on tablet compactibility.  |  Puckhaber, D., et al. 2022. Int J Pharm. 617: 121557. PMID: 35134481
  7. Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a rotary tablet press.  |  de Backere, C., et al. 2022. Int J Pharm. 616: 121562. PMID: 35150846
  8. Impact of lubrication on key properties of orodispersible minitablets in comparison to conventionally sized orodispersible tablets.  |  Kuck, J. and Breitkreutz, J. 2022. Eur J Pharm Biopharm. 180: 71-80. PMID: 36067955
  9. Screening of lubricants towards their applicability for external lubrication.  |  de Backere, C., et al. 2023. Int J Pharm. 632: 122553. PMID: 36586635
  10. Upscaling of external lubrication from a compaction simulator to a rotary tablet press.  |  de Backere, C., et al. 2023. Int J Pharm. 633: 122616. PMID: 36642348

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sodium Stearyl Fumarate, 1 g

sc-473090
1 g
$300.00