Sodium salicylate is a metabolite of acetylsalicylic acid (sc-217570), and functions by inhibiting NF κ B and reduces oxidative stress. The agent has the ability to protect against neurotoxicity induced by glutamate in rat studies. Along with aspirin (sc-202471), sodium salicylate is an anti-inflammatory compound that binds to and inhibits IKK β. Sodium salicylate has been shown to reduce ATP binding in vitro and in vivo. Sodium Salicylate is an inhibitor of c-Jun and Cox-2 and an activator of p38.
1. Kopp, E. and Ghosh, S. 1994. Science. 265: 956-959. PMID: 8052854 2. Grilli, M., et al. 1996. Science. 274: 1383-1385. PMID: 8910280 3. Yin, M.J., et al. 1998. Nature. 396: 77-80. PMID: 9817203 4. Fan, J.R., et al. 2010. Eur. J. Pharmacol. 638: 13-20. PMID: 20406630 5. He, B., et al. 2010. Hepatobiliary Pancreat Dis Int. 9: 49-53. PMID: 20133229
Soluble in water (1000 g/l) at 20° C, ethanol, and glycerol.
Store at room temperature
>300° C (lit.)
0.35 g/cm3 at 20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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WeiWei, et al. (PubMed ID: 20430089) demonstrated that Sodium Salicylate suppressed spontaneous and evoked spike rates in fusiform cells, but not cartwheel cells. -SCBT Publication Review
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