Molecular structure of Sodium Salicylate, CAS Number: 54-21-7
Sodium Salicylate (CAS 54-21-7)
See product citations (8)
Application:
Sodium Salicylate is an NF kappa B inhibitor and reducer of oxidative stress
CAS Number:
54-21-7
Purity:
99%
Molecular Weight:
160.10
Molecular Formula:
C7H5O3•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sodium salicylate is a metabolite of acetylsalicylic acid (sc-217570), and functions by inhibiting NF kappa B and reduces oxidative stress. The agent has the ability to protect against neurotoxicity induced by glutamate in rat studies. Along with aspirin (sc-202471), sodium salicylate is an anti-inflammatory compound that binds to and inhibits IKK beta. Sodium salicylate may act to reduce ATP binding in vitro and in vivo. Sodium Salicylate is an inhibitor of c-Jun and Cox-2 and an activator of p38.
Sodium Salicylate (CAS 54-21-7) References
- The effect of sodium salicylate on bile secretion in the dog. | Rutishauser, SC. and Stone, SL. 1975. J Physiol. 245: 549-65. PMID: 1142217
- Effects of sodium salicylate, aminopyrine and chlorpromazine on behavioral temperature regulation. | Polk, DL. and Lipton, JM. 1975. Pharmacol Biochem Behav. 3: 167-72. PMID: 1144476
- The effects of sodium salicylate on the oxygen consumption of rats. | HSIEH, AC. and CHIU, CC. 1959. Br J Pharmacol Chemother. 14: 219-21. PMID: 13662577
- Sodium salicylate effect on general anesthesia in rats. | BOWMAN, DC., et al. 1962. J Pharmacol Exp Ther. 138: 236-40. PMID: 14014640
- Effect of sodium salicylate on oxidative stress and insulin resistance induced by free fatty acids. | He, B., et al. 2010. Hepatobiliary Pancreat Dis Int. 9: 49-53. PMID: 20133229
- Sodium salicylate acts through direct inhibition of phosphoinositide 3-kinase-like kinases to modulate topoisomerase-mediated DNA damage responses. | Fan, JR., et al. 2010. Eur J Pharmacol. 638: 13-20. PMID: 20406630
- Effect of sodium salicylate, sodium oxalate, and sodium chloride on the micellization and adsorption of sodium deoxycholate in aqueous solutions. | Das, S., et al. 2011. J Colloid Interface Sci. 357: 434-9. PMID: 21402381
- Short communication: Sodium salicylate negatively affects rumen fermentation in vitro and in situ. | Carpenter, AJ., et al. 2017. J Dairy Sci. 100: 1935-1939. PMID: 28088410
- Chestnut extract but not sodium salicylate decreases the severity of diarrhea and enterotoxigenic Escherichia coli F4 shedding in artificially infected piglets. | Girard, M., et al. 2020. PLoS One. 15: e0214267. PMID: 32106264
- Sodium salicylate enhances neural excitation via reducing GABAergic transmission in the dentate gyrus area of rat hippocampus in vivo. | Tang, HP., et al. 2021. Hippocampus. 31: 512-521. PMID: 33580728
- Effect of Sodium Salicylate on Calcium Currents and Exocytosis in Cochlear Inner Hair Cells: Implications for Tinnitus Generation. | Fan, T., et al. 2022. Neurosci Bull. 38: 69-80. PMID: 34235622
- Characterizing the nanomechanical properties of microcomedones after treatment with sodium salicylate ex vivo using atomic force microscopy. | Al-Rekabi, Z., et al. 2021. Int J Cosmet Sci. 43: 610-618. PMID: 34338343
- Sodium salicylate rewires hepatic metabolic pathways in obesity and attenuates IL-1β secretion from adipose tissue: The implications for obesity-impaired reverse cholesterol transport. | Kajani, S., et al. 2022. Mol Metab. 56: 101425. PMID: 34954383
- Sodium salicylate induces browning of white adipocytes via M2 macrophage polarization by HO-1 upregulation. | Choi, HE., et al. 2022. Eur J Pharmacol. 928: 175085. PMID: 35679889
- Prophylactic consequences of sodium salicylate nanoparticles in cisplatin-mediated hepatotoxicity. | Alkhalaf, M., et al. 2023. Sci Rep. 13: 10045. PMID: 37344526
- The effect of sodium salicylate on the rat embryo in culture: an in vitro model for the morphological assessment of teratogenicity. | McGarrity, C., et al. 1981. J Anat. 133: 257-69. PMID: 7333953
- Inhibition of NF-kappa B by sodium salicylate and aspirin. | Kopp, E. and Ghosh, S. 1994. Science. 265: 956-9. PMID: 8052854
- Bovine acute mastitis: effects of intravenous sodium salicylate on endotoxin-induced intramammary inflammation. | Morkoç, AC., et al. 1993. J Dairy Sci. 76: 2579-88. PMID: 8227658
- Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation. | Grilli, M., et al. 1996. Science. 274: 1383-5. PMID: 8910280
- The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. | Yin, MJ., et al. 1998. Nature. 396: 77-80. PMID: 9817203
Inhibitor of:
β-defensin 5, AMPKα1, c-Jun, C11orf93, CNOT7, Cox-2, EG669998, FOXO4, GGA1, H2-Dk, HS3ST4, HSF2, IFN-α10, IKK beta, Lipocalin-6, NALP1, NALP11, NF kappa B, PAPST2, PPARα, PspA, SULT1A3, TNF-IP 8L1, UST, and VSIG8.Activator of:
κB-Ras1, 9G8, AMPKβ1, ANKRD17, ANKRD29, ARMER, Arn1, ATRNL1, C1orf101, C1orf175, C1orf43, CCDC48, Chlamydia LPS, CNF1, COMMD4, copine 4, CRP, CRS4C-5, DDX41, DHRS6, DUSP13, Ear10, Ear14, Ear3, Ear4, Ebi3, EG210155, EG432879, EGFLAM, ENSA, FAM3D, FNIP2, FSTL4, GGPL-I, GGPL-III, H2-M10.1, H2-M10.4, Hep G NS3, HepC NS3, HepC NS5a, HepG NS3, HSPA2, HSPB3, HSV-1 Glycoprotein D, IκB-ε, IFN-α7, IFN-τ, IL-13Rα1, IL-18, IL-27Rα, IL-29, IL-6Rα, INSM2, ISG12b, JDP2, JIP-1, Lipocalin-4, LKB1, LOC100039269, LOC100039346, LOC100039631, LOC100039946, LOC100040214, LOC100041054, LOC100041281, LOC729690, LRG-47, LRRC17, LSAMP, LSm7, LUC7L2, MCPIP, Mig12, MOBKL1B, NALP4A, NALP9C, NBPF6, NLRC5, NNT-1/BSF-3, Nuak1, Oas1h, OSMR β, p38, PIASy, PKR1, PPIAL4B, PPIL2, PRPF18, PRPS3, RADIL, RNF183, rotavirus NSP4, RPRML, RSAD1, SAPS1, SCCPDH, SerpinA3k, SIRT3, Stat, TAF I p110_TAF I p95, Tak1L, Tenr, TNFα-IP 1, TNFα-IP 2, TRADD, TSC-22, TTC1, TTC37, UBE2E1, XPG, XYLB, ZC3HAV1L, and ZCWPW2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sodium Salicylate, 1 g | sc-3520 | 1 g | $10.00 | |||
Sodium Salicylate, 25 g | sc-3520A | 25 g | $25.00 | |||
Sodium Salicylate, 500 g | sc-3520B | 500 g | $80.00 | |||
Sodium Salicylate, 1 kg | sc-3520C | 1 kg | $136.00 |