Sodium Salicylate An NF kappa B inhibitor and reducer of oxidative stress

Sodium Salicylate (CAS 54-21-7)

Sodium Salicylate | CAS 54-21-7 is rated 5.0 out of 5 by 1.
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Application: An NF kappa B inhibitor and reducer of oxidative stress
CAS Number: 54-21-7
Purity: 99%
Molecular Weight: 160.104
Molecular Formula: C7H5O3•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sodium salicylate is a metabolite of acetylsalicylic acid (sc-217570), and functions by inhibiting NF κ B and reduces oxidative stress. The agent has the ability to protect against neurotoxicity induced by glutamate in rat studies. Along with aspirin (sc-202471), sodium salicylate is an anti-inflammatory compound that binds to and inhibits IKK β. Sodium salicylate has been shown to reduce ATP binding in vitro and in vivo. Sodium Salicylate is an inhibitor of c-Jun and Cox-2 and an activator of p38.


References

1. Kopp, E. and Ghosh, S. 1994. Science. 265: 956-959. PMID: 8052854
2. Grilli, M., et al. 1996. Science. 274: 1383-1385. PMID: 8910280
3. Yin, M.J., et al. 1998. Nature. 396: 77-80. PMID: 9817203
4. Fan, J.R., et al. 2010. Eur. J. Pharmacol. 638: 13-20. PMID: 20406630
5. He, B., et al. 2010. Hepatobiliary Pancreat Dis Int. 9: 49-53. PMID: 20133229

Physical State :
Solid
Solubility :
Soluble in water (1000 g/l) at 20° C, ethanol, and glycerol.
Storage :
Store at room temperature
Melting Point :
>300° C (lit.)
Density :
0.35 g/cm3 at 20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
VO5075000
PubChem CID :
16760658
Merck Index :
14: 8332
MDL Number :
MFCD00002440
EC Number :
200-198-0
Beilstein Registry :
3732792
SMILES :
C1=CC=C(C(=C1)C(=O)[O-])O.[Na+]

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Certificate of Analysis

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Sodium Salicylate  Product Citations

See how others have used Sodium Salicylate. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 25616959  2015. Translational research : the journal of laboratory and clinical medicine. 166: 1-11.

PMID: # 20133229  He, B. et al. 2010. HBPD INT. 9: 49-53.

PMID: # 9096313  Schwenger, P. et al. 1997. Proc. Natl. Acad. Sci. USA. 94: 2869-2873.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Wei Wei, et al. (PubMed ID: 20430089) demonstrated that Sodium Salicylate suppressed spontaneous and evoked spike rates in fusiform cells, but not cartwheel cells. -SCBT Publication Review
Date published: 2015-02-12
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