Date published: 2025-11-9

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Sodium periodate (CAS 7790-28-5)

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Alternate Names:
Sodium meta-Periodate
Application:
Sodium periodate is a strong oxidizing hypervalent iodine compound
CAS Number:
7790-28-5
Purity:
≥99%
Molecular Weight:
213.89
Molecular Formula:
NaIO4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sodium periodate, with the chemical formula NaIO4, has emerged as a pivotal reagent in diverse realms of scientific research, showcasing its versatile capabilities and broad utility. One of its primary applications lies in its role as an oxidizing agent, particularly in organic synthesis. Sodium periodate′s ability to cleave vicinal diols into corresponding aldehydes or ketones has been extensively harnessed in the preparation of various chemical intermediates and complex molecules. Furthermore, its selective oxidation properties have found utility in carbohydrate chemistry, where it serves as a valuable tool for the functionalization and modification of polysaccharides and glycoproteins. Recent research efforts have also explored its application in the field of materials science, with studies focusing on its use in the synthesis of nanostructured materials and functionalized surfaces. Additionally, sodium periodate has been investigated for its role in analytical chemistry, particularly in the development of novel detection methods for various analytes. Its compatibility with a wide range of substrates and its relatively mild reaction conditions render it a versatile reagent for diverse research applications spanning organic synthesis, carbohydrate chemistry, materials science, and analytical chemistry.


Sodium periodate (CAS 7790-28-5) References

  1. Sodium periodate treatment modulates the accessory and regulatory functions of alveolar macrophages in T-cell responses.  |  Duque, FT. and Herscowitz, HB. 1989. Reg Immunol. 2: 129-35. PMID: 2561903
  2. The effect of sodium periodate treatment on the modulation of the sodium pump in low-potassium type (LK) sheep red cells by the L antigen.  |  Stein, JM., et al. 1987. Biochim Biophys Acta. 904: 330-6. PMID: 2822119
  3. Sodium periodate-mediated conjugation of harringtonine enabling the production of a highly specific monoclonal antibody, and the development of a sensitive quantitative analysis method.  |  Sakamoto, S., et al. 2017. Analyst. 142: 1140-1148. PMID: 28304015
  4. Sodium-Periodate-Mediated Harringtonine Derivatives and Their Antiproliferative Activity against HL-60 Acute Leukemia Cells.  |  Sakamoto, S., et al. 2018. J Nat Prod. 81: 34-40. PMID: 29286665
  5. Sodium periodate-induced T cell mitogenesis: an analysis of the requirement for Ia and IL 1.  |  Smith, LA., et al. 1985. J Immunol. 135: 1137-44. PMID: 2989361
  6. Rapid sodium periodate cleavage of an unnatural amino acid enables unmasking of a highly reactive α-oxo aldehyde for protein bioconjugation.  |  Brabham, RL., et al. 2020. Org Biomol Chem. 18: 4000-4003. PMID: 32427272
  7. Improving waste activated sludge dewaterability with sodium periodate pre-oxidation on extracellular polymeric substances.  |  Lan, B., et al. 2021. Water Environ Res. 93: 1680-1689. PMID: 33713351
  8. Novel carboxylated cellulose nanocrystals synthesized by co-oxidation of sodium periodate/Fenton as a green solid emulsifier for oil-in-water Pickering emulsion.  |  Wang, B., et al. 2023. J Colloid Interface Sci. 630: 604-617. PMID: 36272215

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sodium periodate, 5 g

sc-203399
5 g
$45.00

Sodium periodate, 100 g

sc-203399A
100 g
$143.00

Sodium periodate, 500 g

sc-203399B
500 g
$364.00