Molecular structure of SN-38 Glucuronide, CAS Number: 121080-63-5
SN-38 Glucuronide (CAS 121080-63-5)
See product citations (5)
Alternate Names:
7-Ethyl-10-hydroxy-camptothecin-10-O-β-Dglucuronide; (4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl b-D-glucopyranosiduronic acid
Application:
SN-38 Glucuronide is a Irinotecan metabolite
CAS Number:
121080-63-5
Purity:
≥95%
Molecular Weight:
568.53
Molecular Formula:
C28H28N2O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SN-38 Glucuronide is a Irinotecan metabolite. Studies have utilized it to examine the effects of SN38 on cancer cells. Findings from in vitro studies have demonstrated that SN38 glucuronide is capable of inhibiting cancer cell proliferation and inducing cell death. Correspondingly, in vivo studies have demonstrated that it can restrict tumor growth in animals. Additionally, SN38 glucuronide may act to possess anti-inflammatory and anti-angiogenic properties.
SN-38 Glucuronide (CAS 121080-63-5) References
- High-performance liquid chromatographic method for the simultaneous determination of the camptothecin derivative irinotecan hydrochloride, CPT-11, and its metabolites SN-38 and SN-38 glucuronide in rat plasma with a fully automated on-line solid-phase extraction system, PROSPEKT. | Kurita, A. and Kaneda, N. 1999. J Chromatogr B Biomed Sci Appl. 724: 335-44. PMID: 10219676
- Population pharmacokinetic model for irinotecan and two of its metabolites, SN-38 and SN-38 glucuronide. | Klein, CE., et al. 2002. Clin Pharmacol Ther. 72: 638-47. PMID: 12496745
- Pharmacogenetic pathway analysis of irinotecan. | Rosner, GL., et al. 2008. Clin Pharmacol Ther. 84: 393-402. PMID: 18418374
- Panipenem does not alter the pharmacokinetics of the active metabolite of irinotecan SN-38 and inactive metabolite SN-38 glucuronide (SN-38G) in rats. | Kato, A., et al. 2011. Anticancer Res. 31: 2915-22. PMID: 21868538
- Rapid deconjugation of SN-38 glucuronide and adsorption of released free SN-38 by intestinal microorganisms in rat. | Takakura, A., et al. 2012. Oncol Lett. 3: 520-524. PMID: 22740943
- [Effect of tacrolimus on the pharmacokinetics and glucuronidation of SN-38, an active metabolite of irinotecan]. | Tanaka, Y., et al. 2013. Yakugaku Zasshi. 133: 463-71. PMID: 23328499
- Pharmacokinetic assessment of irinotecan, SN-38, and SN-38-glucuronide: a substudy of the FIRIS study. | Satoh, T., et al. 2013. Anticancer Res. 33: 3845-53. PMID: 24023318
- Macromolecular prodrug that provides the irinotecan (CPT-11) active-metabolite SN-38 with ultralong half-life, low C(max), and low glucuronide formation. | Santi, DV., et al. 2014. J Med Chem. 57: 2303-14. PMID: 24494988
- Development and validation of an UPLC-MS/MS method for the quantification of irinotecan, SN-38 and SN-38 glucuronide in plasma, urine, feces, liver and kidney: Application to a pharmacokinetic study of irinotecan in rats. | Basu, S., et al. 2016. J Chromatogr B Analyt Technol Biomed Life Sci. 1015-1016: 34-41. PMID: 26894853
- Gene-by-Environment Interaction of Bcrp-/- and Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition. | Toth, EL., et al. 2018. Drug Metab Dispos. 46: 1478-1486. PMID: 30166404
- In vitro metabolic biomodulation of irinotecan to increase potency and reduce dose-limiting toxicity by inhibition of SN-38 glucuronide formation. | Crane, RA., et al. 2022. Drug Metab Pers Ther. 37: 295-303. PMID: 35257538
- Opioid-induced microbial dysbiosis disrupts irinotecan (CPT-11) metabolism and increases gastrointestinal toxicity in a murine model. | Meng, J., et al. 2022. Br J Pharmacol.. PMID: 36562107
- Inhibition of beta-glucuronidase by natural glucuronides of kampo medicines using glucuronide of SN-38 (7-ethyl-10-hydroxycamptothecin) as a substrate. | Narita, M., et al. 1993. Xenobiotica. 23: 5-10. PMID: 8484262
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SN-38 Glucuronide, 500 µg | sc-212931 | 500 µg | $347.00 | |||
SN-38 Glucuronide, 1 mg | sc-212931A | 1 mg | $699.00 | |||
SN-38 Glucuronide, 2.5 mg | sc-212931B | 2.5 mg | $1275.00 | |||
SN-38 Glucuronide, 5 mg | sc-212931C | 5 mg | $2519.00 | |||
SN-38 Glucuronide, 10 mg | sc-212931D | 10 mg | $4399.00 | |||
SN-38 Glucuronide, 50 mg | sc-212931E | 50 mg | $17340.00 |