Molecular structure of Shikonin, CAS Number: 517-89-5
Shikonin (CAS 517-89-5)
See product citations (13)
Application:
Shikonin is a naphthoquinone derivative with angiogenesis inhibitor properties
CAS Number:
517-89-5
Purity:
≥98%
Molecular Weight:
288.3
Molecular Formula:
C16H16O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Shikonin is an active chemical that can be found in the root of Lithospermum erythrorhizon. It is a naphthoquinone derivative and may act to have anti-inflammatory and anti-tumor properties, as well as alter chemokine expression and function. Shikonin can inhibit proliferation and migration of endothelial cells, block integrin alphavbeta3 expression, and inhibit B16 melanoma- and tumor necrosis factor-alpha-induced angiogenesis. Shikonin can down-regulate protein and mRNA expression of CKR-5 (CCR5), a primary HIV-1 coreceptor, in macrophages in HIV studies. Shikonin is an inhibitor of PKM2.
Shikonin (CAS 517-89-5) References
- Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1. | Chen, X., et al. 2003. Antimicrob Agents Chemother. 47: 2810-6. PMID: 12936978
- A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases. | Nigorikawa, K., et al. 2006. Mol Pharmacol. 70: 1143-9. PMID: 16804092
- The efficacy of shikonin on cartilage protection in a mouse model of rheumatoid arthritis. | Kim, YO., et al. 2010. Korean J Physiol Pharmacol. 14: 199-204. PMID: 20827333
- Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1. | Zorman, J., et al. 2016. PLoS One. 11: e0159826. PMID: 27467658
- Correction: Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1. | Zorman, J., et al. 2016. PLoS One. 11: e0163887. PMID: 27657699
- Involvement of LeMDR, an ATP-binding cassette protein gene, in shikonin transport and biosynthesis in Lithospermum erythrorhizon. | Zhu, Y., et al. 2017. BMC Plant Biol. 17: 198. PMID: 29132307
- Involvement of LeMRP, an ATP-binding cassette transporter, in shikonin transport and biosynthesis in Lithospermum erythrorhizon. | Zhu, Y., et al. 2018. Plant Biol (Stuttg). 20: 365-373. PMID: 29139179
- The antityrosinase and antioxidant activities of flavonoids dominated by the number and location of phenolic hydroxyl groups. | Zuo, AR., et al. 2018. Chin Med. 13: 51. PMID: 30364385
- Deoxyshikonin isolated from Arnebia euchroma inhibits colorectal cancer by down-regulating the PI3K/Akt/mTOR pathway. | Zhu, Y., et al. 2019. Pharm Biol. 57: 412-423. PMID: 31230505
- Shikonin regulates autophagy via the AMPK/mTOR pathway and reduces apoptosis of human umbilical cord mesenchymal stem cells to improve survival in tissues surrounding brain contusion. | Zhu, X., et al. 2021. Exp Ther Med. 22: 1475. PMID: 34765016
- Dual-functional shikonin-loaded quaternized chitosan/polycaprolactone nanofibrous film with pH-sensing for active and intelligent food packaging. | Zou, Y., et al. 2023. Food Chem. 399: 133962. PMID: 36007440
- [The antiinflammatory activity of shikonin and its inhibitory effect on leukotriene B4 biosynthesis]. | Wang, WJ., et al. 1994. Yao Xue Xue Bao. 29: 161-5. PMID: 8079645
- Shikonin, an ingredient of Lithospermum erythrorhizon, inhibits angiogenesis in vivo and in vitro. | Hisa, T., et al. 1998. Anticancer Res. 18: 783-90. PMID: 9615720
Inhibitor of:
Angiogenesis, PKM2, and PRMT1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Shikonin, 10 mg | sc-200391 | 10 mg | $75.00 | |||
Shikonin, 50 mg | sc-200391A | 50 mg | $223.00 |