Molecular structure of Safranal, CAS Number: 116-26-7
Safranal (CAS 116-26-7)
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Alternate Names:
2,6,6-Trimethyl-1,3-cyclohexadiene-1-carboxaldehyde
CAS Number:
116-26-7
Purity:
≥80%
Molecular Weight:
150.22
Molecular Formula:
C10H14O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Safranal is a chemical that is isolated from Saffron. This chemical is responsible for the distinct aroma of saffron. It has also been shown to have GABAA R agonist activity in vitro which is an interesting area of research. Safranal, an organic compound present in saffron essential oil, has a long history of culinary, medicinal, and perfumery use. Classified as an aldehyde, it consists of carbon, hydrogen, and oxygen atoms, appearing as a yellow liquid. Safranal act as an anti-inflammatory agent by inhibiting the release of pro-inflammatory cytokines and reducing the production of reactive oxygen species. Secondly, it functions as an antioxidant, effectively scavenging free radicals and limiting the generation of reactive oxygen species.
Safranal (CAS 116-26-7) References
- Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice. | Hosseinzadeh, H. and Talebzadeh, F. 2005. Fitoterapia. 76: 722-4. PMID: 16253437
- Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems. | Hosseinzadeh, H. and Sadeghnia, HR. 2007. Phytomedicine. 14: 256-62. PMID: 16707256
- Crocetin, dimethylcrocetin, and safranal bind human serum albumin: stability and antioxidative properties. | Kanakis, CD., et al. 2007. J Agric Food Chem. 55: 970-7. PMID: 17263501
- Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice. | Hosseinzadeh, H. and Noraei, NB. 2009. Phytother Res. 23: 768-74. PMID: 19142981
- Assessment of cytotoxic properties of safranal and nanoliposomal safranal in various cancer cell lines. | Malaekeh-Nikouei, B., et al. 2013. Phytother Res. 27: 1868-73. PMID: 23494763
- Safranal: from an aromatic natural product to a rewarding pharmacological agent. | Rezaee, R. and Hosseinzadeh, H. 2013. Iran J Basic Med Sci. 16: 12-26. PMID: 23638289
- Safranal treatment improves hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats. | Samarghandian, S., et al. 2013. J Pharm Pharm Sci. 16: 352-62. PMID: 23958204
- DNA fragmentation and apoptosis induced by safranal in human prostate cancer cell line. | Samarghandian, S. and Shabestari, MM. 2013. Indian J Urol. 29: 177-83. PMID: 24082436
- Acute and subacute toxicity of safranal, a constituent of saffron, in mice and rats. | Hosseinzadeh, H., et al. 2013. Iran J Pharm Res. 12: 93-9. PMID: 24250576
- Anti-tumor activity of safranal against neuroblastoma cells. | Samarghandian, S., et al. 2014. Pharmacogn Mag. 10: S419-24. PMID: 24991121
- Preventive effect of safranal against oxidative damage in aged male rat brain. | Samarghandian, S., et al. 2015. Exp Anim. 64: 65-71. PMID: 25312506
- Saffron bioactives crocin, crocetin and safranal: effect on oxidative stress and mechanisms of action. | Cerdá-Bernad, D., et al. 2022. Crit Rev Food Sci Nutr. 62: 3232-3249. PMID: 33356506
- The role of Safranal and saffron stigma extracts in oxidative stress, diseases and photoaging: A systematic review. | Nanda, S. and Madan, K. 2021. Heliyon. 7: e06117. PMID: 33615006
- Safranal Prevents Liver Cancer Through Inhibiting Oxidative Stress and Alleviating Inflammation. | Abdalla, Y., et al. 2021. Front Pharmacol. 12: 777500. PMID: 35177980
- Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. | Escribano, J., et al. 1996. Cancer Lett. 100: 23-30. PMID: 8620447
Activator of:
GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Safranal, 5 g | sc-472985 | 5 g | $153.00 | |||
Safranal, 10 g | sc-472985A | 10 g | $245.00 | |||
Safranal, 25 g | sc-472985C | 25 g | $428.00 | |||
Safranal, 50 g | sc-472985B | 50 g | $673.00 | |||
Safranal, 100 g | sc-472985D | 100 g | $1183.00 |