Roquefortine C is a mycotoxin produced by Penicillium roqueforti and P. crustosum. This compound has been noted to cause serious toxic effects in cell lines. In some experiments, Roquefortine C has been used as a biomarker for penitrem A intoxication. Studies suggest that G protein-mediated signaling is a key component of Roquefortine C production by Penicillium roqueforti. Further experiments report that Roquefortine C is potentially a neurotoxic compound that activates and inhibits detoxification enzymes Mdr (P-glycoprotein, P-gp) and CYP (cytochrome P450-3A), respectively.
1. Keblys, M., et al. 2004. Mycopathologia. 158: 317-324. PMID: 15702270 2. Bünger, J., et al. 2004. Toxicology. 202: 199-211. PMID: 15337583 3. Aninat, C., et al. 2005. Food Addit Contam. 22: 361-368. PMID: 16019806 4. García-Rico, R.O., et al. 2009. Int. Microbiol. 12: 123-129. PMID: 19784932 5. Tiwary, A.K., et al. 2009. J. Vet. Diagn. Invest. 21: 237-239. PMID: 19286504
Soluble in 100% ethanol, methanol (10 mg/ml), DMSO (10 mg/ml), DMF, and water (poor).
Store at -20° C
303.10° C (Predicted)
768.27° C at 760 mmHg (Predicted)
1.37 g/cm3 (Predicted)
n20D 1.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Rand et alRand et al. (PubMed ID 15958659) found that the neurotoxin, Roquefortine C, induced tumor necrosis factor- , MIP-2, and IL-6 production. The activation of these proteins resulted in a significant inflammatory response in mouse lungs infected with Penicillium spores. -SCBT Publication Review
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