Roquefortine C is a mycotoxin produced by Penicillium roqueforti and P. crustosum. This compound has been noted to cause serious toxic effects in cell lines. In some experiments, Roquefortine C has been used as a biomarker for penitrem A intoxication. Studies suggest that G protein-mediated signaling is a key component of Roquefortine C production by Penicillium roqueforti. Further experiments report that Roquefortine C is potentially a neurotoxic compound that activates and inhibits detoxification enzymes Mdr (P-glycoprotein, P-gp) and CYP (cytochrome P450-3A), respectively.
1. Keblys, M., et al. 2004. Mycopathologia. 158: 317-324. PMID: 15702270
2. Bünger, J., et al. 2004. Toxicology. 202: 199-211. PMID: 15337583
3. Aninat, C., et al. 2005. Food Addit Contam. 22: 361-368. PMID: 16019806
4. García-Rico, R.O., et al. 2009. Int. Microbiol. 12: 123-129. PMID: 19784932
5. Tiwary, A.K., et al. 2009. J. Vet. Diagn. Invest. 21: 237-239. PMID: 19286504
See how others have used Roquefortine C. Click on the entry to view the PubMed entry .
PMID: # 25580944 Cakmakci, S. et al. 2015. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 32: 245-9.
PMID: # 23127715 Cakmakci, S. et al. 2012. Journal of food protection. 75: 2045-9.
PMID: # 15958659 Rand, TG. et al. 2005. Toxicol. Sci. 87: 213-222.
PMID: # 2730153 Frisvad, JC. et al. 1989 May-Jun. Arch. Environ. Contam. Toxicol. 18: 331-335.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.