Roquefortine C Roquefortine C is a potential neurotoxin and a mycotoxin . Shown to activate and inhibit detoxification enzymes Mdr (P-glycoprotein, P-gp) and CYP (cytochrome P450-3A), respectively.

Roquefortine C  (CAS 58735-64-1)

Roquefortine C is rated 5.0 out of 5 by 1.
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| See 4 Citations
Application: A potent neurotoxin produced most notably by Penicillium species
CAS Number: 58735-64-1
Purity: >99%
Molecular Weight: 389.5
Molecular Formula: C22H23N5O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Roquefortine C sc-202323 500 µg $350.00

Roquefortine C is a mycotoxin produced by Penicillium roqueforti and P. crustosum. This compound has been noted to cause serious toxic effects in cell lines. In some experiments, Roquefortine C has been used as a biomarker for penitrem A intoxication. Studies suggest that G protein-mediated signaling is a key component of Roquefortine C production by Penicillium roqueforti. Further experiments report that Roquefortine C is potentially a neurotoxic compound that activates and inhibits detoxification enzymes Mdr (P-glycoprotein, P-gp) and CYP (cytochrome P450-3A), respectively.


References

1. Keblys, M., et al. 2004. Mycopathologia. 158: 317-324. PMID: 15702270
2. Bünger, J., et al. 2004. Toxicology. 202: 199-211. PMID: 15337583
3. Aninat, C., et al. 2005. Food Addit Contam. 22: 361-368. PMID: 16019806
4. García-Rico, R.O., et al. 2009. Int. Microbiol. 12: 123-129. PMID: 19784932
5. Tiwary, A.K., et al. 2009. J. Vet. Diagn. Invest. 21: 237-239. PMID: 19286504

Physical State :
Solid
Derived From :
Unidentified fungus
Solubility :
Soluble in 100% ethanol, methanol (10 mg/ml), DMSO (10 mg/ml), DMF, and water (poor).
Storage :
Store at -20° C
Melting Point :
303.10° C (Predicted)
Boiling Point :
768.27° C at 760 mmHg (Predicted)
Density :
1.37 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UQ4730500
PubChem CID :
6436831
MDL Number :
MFCD22416530
SMILES :
CC(C)(C=C)[C@@]12C[C@H]3C(=O)N/C(=CC4=CN=CN4)/C(=O)N3[C@@H]1NC5=CC=CC=C25

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Certificate of Analysis

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Roquefortine C Product Citations

See how others have used Roquefortine C. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 25580944
Cakmakci, S. et al. 2015. Mycotoxin production capability of Penicillium roqueforti in strains isolated from mould-ripened traditional Turkish civil cheese. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 32: 245-9.

PMID: # 23127715
Cakmakci, S. et al. 2012. Morphological, molecular, and mycotoxigenic identification of dominant filamentous fungi from moldy civil cheese. Journal of food protection. 75: 2045-9.

PMID: # 15958659
Rand, TG. et al. 2005. Inflammatory and cytotoxic responses in mouse lungs exposed to purified toxins from building isolated Penicillium brevicompactum Dierckx and P. chrysogenum Thom. Toxicol. Sci.. 87: 213-222.

PMID: # 2730153
Frisvad, JC. et al. 1989 May-Jun. Analysis and screening for mycotoxins and other secondary metabolites in fungal cultures by thin-layer chromatography and high-performance liquid chromatography. Arch. Environ. Contam. Toxicol.. 18: 331-335.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Rand et al Rand et al. (PubMed ID 15958659) found that the neurotoxin, Roquefortine C, induced tumor necrosis factor- , MIP-2, and IL-6 production. The activation of these proteins resulted in a significant inflammatory response in mouse lungs infected with Penicillium spores. -SCBT Publication Review
Date published: 2015-06-26
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