Molecular structure of Rhapontigenin, CAS Number: 500-65-2
Rhapontigenin (CAS 500-65-2)
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Alternate Names:
Rhapontigenin is known as a natural analog of resveratrol.
Application:
ARhapontigenin is a natural analog of resveratrol and an inhibitor of CYP1A1, with antioxidant and anti-cancer activity.
CAS Number:
500-65-2
Purity:
≥98%
Molecular Weight:
258.27
Molecular Formula:
C15H14O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. Rhapontigenin is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. At higher concentrations, Rhapontigenin inhibits the proliferation of Hep-G2 and HL-60R cancer cell lines (IC50 = 48 μM).
Rhapontigenin (CAS 500-65-2) References
- Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin. | Chun, YJ., et al. 2001. Drug Metab Dispos. 29: 389-93. PMID: 11259321
- Preparative enzymatic synthesis and HPLC analysis of rhapontigenin: applications to metabolism, pharmacokinetics and anti-cancer studies. | Roupe, KA., et al. 2005. J Pharm Pharm Sci. 8: 374-86. PMID: 16401387
- Rhapontigenin from Rheum undulatum protects against oxidative-stress-induced cell damage through antioxidant activity. | Zhang, R., et al. 2007. J Toxicol Environ Health A. 70: 1155-66. PMID: 17558811
- Evaluation of the antibacterial activity of rhapontigenin produced from rhapontin by biotransformation against Propionibacterium acnes. | Kim, JK., et al. 2010. J Microbiol Biotechnol. 20: 82-7. PMID: 20134237
- Rhapontigenin inhibited hypoxia inducible factor 1 alpha accumulation and angiogenesis in hypoxic PC-3 prostate cancer cells. | Jung, DB., et al. 2011. Biol Pharm Bull. 34: 850-5. PMID: 21628883
- The possible mechanism of rhapontigenin influencing antifungal activity on Candida albicans. | Kim, N., et al. 2013. Med Mycol. 51: 45-52. PMID: 22662760
- Rhapontigenin converted from rhapontin purified from Rheum undulatum enhances the inhibition of melanin synthesis. | Lee, HS., et al. 2012. Biosci Biotechnol Biochem. 76: 2307-9. PMID: 23221688
- Rhapontigenin suppresses cell migration and invasion by inhibiting the PI3K-dependent Rac1 signaling pathway in MDA-MB-231 human breast cancer cells. | Kim, JS., et al. 2014. J Nat Prod. 77: 1135-9. PMID: 24828286
- Antihyperlipidemic effects of rhapontin and rhapontigenin from rheum undulatum in rats fed a high-cholesterol diet. | Jo, SP., et al. 2014. Planta Med. 80: 1067-71. PMID: 25127020
- Rhapontigenin inhibits TGF-β-mediated epithelial‑mesenchymal transition via the PI3K/AKT/mTOR pathway and is not associated with HIF-1α degradation. | Yeh, YH., et al. 2016. Oncol Rep. 35: 2887-95. PMID: 26986649
- Cardioprotective Effect of Rhapontigenin in Isoproterenol-Induced Myocardial Infarction in a Rat Model. | Fan, Y. 2019. Pharmacology. 103: 291-302. PMID: 30820014
- Identification of the metabolites of rhapontigenin in rat and human by ultra-high-performance liquid chromatography-high-resolution mass spectrometry. | An, J., et al. 2021. Rapid Commun Mass Spectrom. 35: e9180. PMID: 34363627
- Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow. | Xie, C., et al. 2022. Nat Biomed Eng. 6: 76-93. PMID: 34992270
- Effects of Rhapontigenin as a Novel Quorum-Sensing Inhibitor on Exoenzymes and Biofilm Formation of Pectobacterium carotovorum subsp. carotovorum and Its Application in Vegetables. | Li, B., et al. 2022. Molecules. 27: PMID: 36558013
Inhibitor of:
CYP, and CYP1A1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rhapontigenin, 1 mg | sc-296263 | 1 mg | $154.00 | |||
Rhapontigenin, 5 mg | sc-296263A | 5 mg | $600.00 | |||
Rhapontigenin, 10 mg | sc-296263B | 10 mg | $1175.00 |