Molecular structure of Reserpine, CAS Number: 50-55-5
Reserpine (CAS 50-55-5)
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Alternate Names:
Serpalan; Serpasil; Hiserpia; Serpanray; Serpivite; Apoplon
Application:
Reserpine is an inhibitor of transport of biogenic amines into adrenal chromaffin granules
CAS Number:
50-55-5
Purity:
≥98%
Molecular Weight:
608.68
Molecular Formula:
C33H40N2O9
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Reserpine has displayed a capacity to inhibit the transport of biogenic amines into synaptic vesicles and adrenal chromaffin granules. The mechanism behind this inhibition has been illuminated as an irreversible binding to the vesicular amine transporter. Furthermore, Reserpine has been reported to interfere with dopamine transporter activity and potently inhibit synaptosomal dopamine uptake. Reserpine is an inhibitor of VMAT 2.
Reserpine (CAS 50-55-5) References
- Effect of reserpine on behavioural responses to agonists at 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor subtypes. | Heslop, KE. and Curzon, G. 1999. Neuropharmacology. 38: 883-91. PMID: 10465692
- Inhibitory effect of reserpine on dopamine transporter function. | Metzger, RR., et al. 2002. Eur J Pharmacol. 456: 39-43. PMID: 12450567
- Oral reserpine administration in horses results in low plasma concentrations that alter platelet biology. | Gilbertie, JM., et al. 2019. Equine Vet J. 51: 537-543. PMID: 30465727
- Reserpine attenuates biofilm formation and virulence of Staphylococcus aureus. | Parai, D., et al. 2020. Microb Pathog. 138: 103790. PMID: 31605761
- Reserpine Substantially Lowers Blood Pressure in Patients With Refractory Hypertension: A Proof-of-Concept Study. | Siddiqui, M., et al. 2020. Am J Hypertens. 33: 741-747. PMID: 32179903
- Reserpine inhibits DNA repair, cell proliferation, invasion and induces apoptosis in oral carcinogenesis via modulation of TGF-β signaling. | Ramu, AK., et al. 2021. Life Sci. 264: 118730. PMID: 33160994
- Daphnetin, a natural coumarin averts reserpine-induced fibromyalgia in mice: modulation of MAO-A. | Singh, L., et al. 2021. Exp Brain Res. 239: 1451-1463. PMID: 33677656
- Pioglitazone improves skeletal muscle functions in reserpine-induced fibromyalgia rat model. | Hassan, FE., et al. 2021. Ann Med. 53: 1032-1040. PMID: 34233552
- Reserpine-induced altered neuro-behavioral, biochemical and histopathological assessments prevent by enhanced antioxidant defence system of thymoquinone in mice. | Samad, N., et al. 2021. Metab Brain Dis. 36: 2535-2552. PMID: 34309746
- Neonatal Reserpine Administration Produces Widespread Neuronal Losses and ⍺-Synuclein Inclusions in a Rat Model. | van Onselen, R. and Downing, TG. 2021. Neurotox Res. 39: 1762-1770. PMID: 34727322
- Reserpine improves Enterobacteriaceae resistance in chicken intestine via neuro-immunometabolic signaling and MEK1/2 activation. | Redweik, GAJ., et al. 2021. Commun Biol. 4: 1359. PMID: 34862463
- Piperine, Reserpine and β-Sitosterol Attenuate Stem Rot (Sclerotium rolfsii Sacc.) of Groundnut by Inducing the Secretion of defense Enzymes and Phenolic Acids. | Lakshmi, N., et al. 2022. Chem Biodivers. 19: e202100880. PMID: 35182415
- Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice. | Ferrarini, EG., et al. 2022. Biomed Pharmacother. 154: 113552. PMID: 35988425
- Physical exercise prevents behavioral alterations in a reserpine-treated zebrafish: A putative depression model. | de Melo Martins, GM., et al. 2022. Pharmacol Biochem Behav. 220: 173455. PMID: 36063969
- Reserpine binding to a vesicular amine transporter expressed in Chinese hamster ovary fibroblasts. | Schuldiner, S., et al. 1993. J Biol Chem. 268: 29-34. PMID: 8416935
Inhibitor of:
1110021L09Rik, 4933427G17Rik, ABCA14, ABCA15, ABCA16, ABCA17, Abca8a, C1orf194, C6orf192, Chr-A, CNT1, D730048I06Rik, D930020B18Rik, DBH, Dopamine, LEP503, MAB21L1, Mtvr2, Muted, NAT-16, Neu, Olfr739, Olfr821, Olfr881, Olfr988, OR1L1, OR52E5, PCB, Pdr5, PNMTase, proenkephalin A, SLC10A4, SLC29 (solute carrier family 29), Synapsin Ia/b, TAAR7B, TAAR8C, TH, TRH-DE, Triiodothyronine, VMAT 2, Vmn2r20, Vmn2r4, and Vmn2r90.Activator of:
alpha2A-AR, Artn, CYP1A2, D1DR, DDC, MRP6, Neuropeptide S, Preprotachykinin, SV2B, and VMAT 1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Reserpine, 1 g | sc-203370 | 1 g | $134.00 | |||
Reserpine, 5 g | sc-203370A | 5 g | $406.00 |