Quinoxyfen (CAS 124495-18-7)

Quinoxyfen is a quinoline-based fungicide specifically designed for the control of powdery mildew in cereals and grapes. Its mechanism of action is distinct and involves the inhibition of fungal respiration at a site different from other fungicides, categorizing it as a mitochondrial electron transport inhibitor. Quinoxyfen primarily targets the complex III (cytochrome bc1 complex) in the mitochondrial electron transport chain of fungi, which is crucial for cellular energy production. By binding to this site, it disrupts electron transport, leading to a cessation of ATP production and ultimately causing fungal cell death. This mode of action is highly specific to fungi, making Quinoxyfen a valuable tool in agricultural research, particularly in studies aimed at understanding and managing fungal resistance. Its unique binding affinity and inhibition profile have also made it a subject of interest in basic biochemical research, where it is used to study the structure and function of mitochondrial complexes in various fungal species. Additionally, researchers utilize Quinoxyfen to explore the ecological impact of fungicides on non-target fungal communities, which is critical for developing sustainable agricultural practices and understanding the broader environmental consequences of fungicide use.