Molecular structure of Pyrroloquinoline quinone, CAS Number: 72909-34-3
Pyrroloquinoline quinone (CAS 72909-34-3)
Alternate Names:
PQQ
Application:
Pyrroloquinoline quinone is a redox/cofactor found in a a class of enzymes called quinoproteins
CAS Number:
72909-34-3
Molecular Weight:
330.20
Molecular Formula:
C14H6N2O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Pyrroloquinoline quinone is a redox cofactor that functions as a coenzyme in various oxidation-reduction reactions within biological systems. It acts as a potent antioxidant, scavenging free radicals and protecting cells from oxidative damage. At the molecular level, it interacts with proteins involved in cellular energy metabolism, enhancing mitochondrial function and promoting the production of adenosine triphosphate (ATP). Pyrroloquinoline Quinone also plays a role in the activation of transcription factors, influencing gene expression related to cellular growth and development. Pyrroloquinoline quinone may support the growth and differentiation of certain cell types, contributing to cellular health and function. Its mechanism of action involves modulating signaling pathways and enzymatic activity, ultimately impacting cellular processes such as proliferation, survival, and metabolism.
Pyrroloquinoline quinone (CAS 72909-34-3) References
- Pyrroloquinoline Quinone Prevents Estrogen Deficiency-Induced Osteoporosis by Inhibiting Oxidative Stress and Osteocyte Senescence. | Geng, Q., et al. 2019. Int J Biol Sci. 15: 58-68. PMID: 30662347
- Effects of pyrroloquinoline quinone and imidazole pyrroloquinoline on biological activities and neural functions. | Yamada, Y., et al. 2020. Heliyon. 6: e03240. PMID: 32021931
- Pyrroloquinoline quinone promotes mitochondrial biogenesis in rotenone-induced Parkinson's disease model via AMPK activation. | Cheng, Q., et al. 2021. Acta Pharmacol Sin. 42: 665-678. PMID: 32860006
- Pyrroloquinoline Quinone Inhibits Rotenone-Induced Microglia Inflammation by Enhancing Autophagy. | Zhang, Q., et al. 2020. Molecules. 25: PMID: 32977419
- Pyrroloquinoline quinone attenuated benzyl butyl phthalate induced metabolic aberration and a hepatic metabolomic analysis. | Zhang, J., et al. 2022. Biochem Pharmacol. 197: 114883. PMID: 34971587
- Pyrroloquinoline quinone ameliorates diabetic cardiomyopathy by inhibiting the pyroptosis signaling pathway in C57BL/6 mice and AC16 cells. | Qu, XF., et al. 2022. Eur J Nutr. 61: 1823-1836. PMID: 34997266
- Pyrroloquinoline quinone ameliorates liver injury in mice induced by cyclophosphamide. | Qian, L., et al. 2022. Environ Sci Pollut Res Int. 29: 30383-30393. PMID: 34997497
- Pyrroloquinoline Quinone Disodium (PQQ2Na) Has an NLRP Inflammasome-Induced Caspase-1 Release Influence in UVB-Irradiated but Not ATP-Treated Human Keratinocytes but Has No Influence in Increasing Skin Cell Mitochondrial Biogenesis in Either Human Keratinocytes or Fibroblasts. | Gruber, JV. and Holtz, R. 2022. Clin Cosmet Investig Dermatol. 15: 107-115. PMID: 35087283
- Pyrroloquinoline quinone ameliorates renal fibrosis in diabetic nephropathy by inhibiting the pyroptosis pathway in C57BL/6 mice and human kidney 2 cells. | Qu, X., et al. 2022. Biomed Pharmacother. 150: 112998. PMID: 35489281
- Pyrroloquinoline Quinone Regulates Enteric Neurochemical Plasticity of Weaned Rats Challenged With Lipopolysaccharide. | Shi, C., et al. 2022. Front Neurosci. 16: 878541. PMID: 35592257
- Pyrroloquinoline quinone (PQQ) protects mitochondrial function of HEI-OC1 cells under premature senescence. | Gao, Y., et al. 2022. NPJ Aging. 8: 3. PMID: 35927260
- Pyrroloquinoline quinone (PQQ) improves pulmonary hypertension by regulating mitochondrial and metabolic functions. | Shafiq, M., et al. 2022. Pulm Pharmacol Ther. 76: 102156. PMID: 36030026
- Effects of pyrroloquinoline quinone on noise-induced and age-related hearing loss in mice. | Gao, Y., et al. 2022. Sci Rep. 12: 15911. PMID: 36151123
- Pyrroloquinoline quinone modulates YAP-related anti-ferroptotic activity to protect against myocardial hypertrophy. | Zhou, J., et al. 2022. Front Pharmacol. 13: 977385. PMID: 36238573
- Pyrroloquinoline Quinone Administration Alleviates Allergic Airway Inflammation in Mice by Regulating the JAK-STAT Signaling Pathway. | Min, Z., et al. 2022. Mediators Inflamm. 2022: 1267841. PMID: 36345503
Inhibitor of:
ATP5SL, mtp110, PLC β4, SDHB, and TRM12.Activator of:
1190007I07Rik, 1810043H04Rik, 3-Hydroxybutyrate Dehydrogenase, AARS2, AATC, ADCK4, AMID, ANT1, ATP11, ATP5D, C12orf65_2810006K23Rik, C4orf14, C5orf33, C8orf38, CABC1, CGBP, CHCHD10, CHCHD6, CHCHD8, COQ10B, COQ4, COQ7, COQ9, COX15, COX18, COX7a2L, DHS, DNC, Doxl2, ENOSF1, FOXO6, FOXRED1, FucT-IV, GDAP1, GDAP1L1, GTPBP3, HIGD1A, HtrA2, IMMP1L, LACE1, MCART1, MCART2, Mitochondrial Inner Membrane, MRP-L13, MRP-L3, MRP-L40, MRP-L44, MRP-L46, MRP-L9, MRP-S21, MRP-S26, MRP-S30, MRP-S5, MRRF, MTO1, MTP18, MTRNR2L10, MTRNR2L3, MTRNR2L4, MTRNR2L7, ND2, ND3, ND4, ND5, NDUFA11, NDUFA12, NDUFA2, NDUFA3, NDUFA4L2, NDUFA9, NDUFAF3, NDUFAF7, NDUFB10, NDUFB2, NDUFB4, NDUFB7, NDUFB8, NDUFB9, NDUFC2, NDUFS2, NDUFS5, NDUFS6, NDUFS7, NDUFS8, nm23-H4, NMNAT-1, Nrf1, NSUN3, OSCP1, p60 Mitochondrial Marker, PACRG, PITRM1, PQLC1, PROSC, PSMD1, QCR10, RG9MTD1, SCAF1, SLC25A41, SLN, SQRDL, SS18L2, SSBP1, TERE1, TFB2M, Tim8B, Tomm5, TTC19, UBE2G2, UQCRC2, VAT1L, and XRCC6BP1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pyrroloquinoline quinone, 1 mg | sc-210178 | 1 mg | $243.00 |