Molecular structure of Pyrazinamide, CAS Number: 98-96-4
Pyrazinamide (CAS 98-96-4)
Alternate Names:
Pyrazinecarboxamide; Pyranzinoic acid amide
Application:
Pyrazinamide is an antibacterial agent used to study liver toxicity prevention
CAS Number:
98-96-4
Purity:
≥98%
Molecular Weight:
123.11
Molecular Formula:
C5H5N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Pyrazinamide is an antibacterial agent used to form polymeric copper complexes. It is also useful for studying liver toxicity prevention. The active moiety of pyrazinamide, pyrazinoic acid (POA), interferes with membrane energetics and transport function in Mycobacterium tuberculosis. This bacterium produces the enzyme pyrazinamidase, which activates Pyrazinamide. The compound inhibits the synthesis of fatty acids, cell walls, proteins, DNA, and RNA. It has also been reported to exhibit anti-inflammatory, anti-tumor, and anti-viral activities.
Pyrazinamide (CAS 98-96-4) References
- The curious characteristics of pyrazinamide: a review. | Zhang, Y. and Mitchison, D. 2003. Int J Tuberc Lung Dis. 7: 6-21. PMID: 12701830
- Pyrazinamide may possess cardioprotective properties. | Sinha, S., et al. 2019. J Antibiot (Tokyo). 72: 714-717. PMID: 31243346
- The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD. | Sun, Q., et al. 2020. Nat Commun. 11: 339. PMID: 31953389
- The phase relationship between the pyrazinamide polymorphs α and γ. | Li, K., et al. 2020. Int J Pharm. 580: 119230. PMID: 32199962
- Pyrazinamide triggers degradation of its target aspartate decarboxylase. | Gopal, P., et al. 2020. Nat Commun. 11: 1661. PMID: 32245967
- Antimicrobial Activity of Pyrazinamide Coordination Frameworks Synthesized by Mechanochemistry. | Quaresma, S., et al. 2021. Molecules. 26: PMID: 33800635
- Diagnostic Accuracy of Pyrazinamide Susceptibility Testing in Mycobacterium tuberculosis: A Systematic Review with Meta-Analysis. | Bagheri, M., et al. 2022. Microb Drug Resist. 28: 87-98. PMID: 34582723
- PanB over-representation as part of pyrazinamide action: a proteomic insight. | Barros, ILE., et al. 2021. Future Microbiol. 16: 1303-1308. PMID: 34743541
- Comparative Performance of Genomic Methods for the Detection of Pyrazinamide Resistance and Heteroresistance in Mycobacterium tuberculosis. | Whitfield, MG., et al. 2022. J Clin Microbiol. 60: e0190721. PMID: 34757831
- Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis. | Thiede, JM., et al. 2021. mBio. 13: e0043921. PMID: 35100871
- Neurodevelopmental toxicity of pyrazinamide to larval zebrafish and the restoration after intoxication withdrawal. | Wang, X., et al. 2022. J Appl Toxicol. 42: 1276-1286. PMID: 35102572
- Novel Regimens of Bedaquiline-Pyrazinamide Combined with Moxifloxacin, Rifabutin, Delamanid and/or OPC-167832 in Murine Tuberculosis Models. | Tasneen, R., et al. 2022. Antimicrob Agents Chemother. 66: e0239821. PMID: 35315690
- Visualizing Pyrazinamide Action by Live Single-Cell Imaging of Phagosome Acidification and Mycobacterium tuberculosis pH Homeostasis. | Santucci, P., et al. 2022. mBio. 13: e0011722. PMID: 35323041
- Pyrazinamide enhances persistence of T-cell memory induced by tuberculosis subunit vaccine LT70. | Niu, H., et al. 2022. Tuberculosis (Edinb). 135: 102220. PMID: 35679762
- Pyrazinamide resistance in rifampicin discordant tuberculosis. | Mvelase, NR., et al. 2022. PLoS One. 17: e0274688. PMID: 36129921
Inhibitor of:
β-ketoacyl synthase, AASDHPPT, AMDHD1, AUH, DDO, Fatty Acid Synthase, Glut9, HGD, Lipid A, LYRM7, Mycobacterium avium, NIT2, OAT6, Olfr606, RV2623 Dormancy Regulon, RV3134 Dormancy Regulon, SLC17A4, and SLC22A12.Activator of:
Ag85, ESAT6, MT 38 kDa antigen, and SLC22A12.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pyrazinamide, 10 g | sc-205824 | 10 g | $49.00 | |||
Pyrazinamide, 25 g | sc-205824A | 25 g | $67.00 | |||
Pyrazinamide, 100 g | sc-205824B | 100 g | $89.00 | |||
Pyrazinamide, 250 g | sc-205824C | 250 g | $151.00 | |||
Pyrazinamide, 1 kg | sc-205824D | 1 kg | $483.00 | |||
Pyrazinamide, 5 kg | sc-205824E | 5 kg | $2276.00 |