Date published: 2025-10-14

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Protodioscin (CAS 55056-80-9)

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Alternate Names:
Furostanol I
Application:
Protodioscin is a steroidal saponin found in tribulus terrestris
CAS Number:
55056-80-9
Molecular Weight:
1049.20
Molecular Formula:
C51H84O22
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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A steroidal saponin found in tribulus terrestris and other plants. It has been found to trigger the release of nitric oxide in corpus cavernosum tissue and also produce statistically significant increases in hormonal levels.


Protodioscin (CAS 55056-80-9) References

  1. Proerectile pharmacological effects of Tribulus terrestris extract on the rabbit corpus cavernosum.  |  Adaikan, PG., et al. 2000. Ann Acad Med Singap. 29: 22-6. PMID: 10748960
  2. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction--an evaluation using primates, rabbit and rat.  |  Gauthaman, K. and Ganesan, AP. 2008. Phytomedicine. 15: 44-54. PMID: 18068966
  3. Protodioscin protects PC12 cells against oxygen and glucose deprivation-induced injury through miR-124/AKT/Nrf2 pathway.  |  Shu, K. and Zhang, Y. 2019. Cell Stress Chaperones. 24: 1091-1099. PMID: 31446555
  4. Natural intoxication caused by protodioscin in lambs kept in Brachiaria pastures.  |  da Costa, MCM., et al. 2021. Trop Anim Health Prod. 53: 336. PMID: 34021407
  5. Protodioscin Induces Mitochondrial Apoptosis of Human Hepatocellular Carcinoma Cells Through Eliciting ER Stress-Mediated IP3R Targeting Mfn1/Bak Expression.  |  Yu, CL., et al. 2022. J Hepatocell Carcinoma. 9: 327-341. PMID: 35496076
  6. Protodioscin protects porcine oocytes against H2O2-induced oxidative stress during in vitro maturation.  |  Kim, SH., et al. 2023. Anim Biosci. 36: 710-719. PMID: 36397686
  7. Protodioscin inhibits bladder cancer cell migration and growth, and promotes apoptosis through activating JNK and p38 signaling pathways.  |  Chen, YR., et al. 2022. Biomed Pharmacother. 156: 113929. PMID: 36411619
  8. Mitophagy Effects of Protodioscin on Human Osteosarcoma Cells by Inhibition of p38MAPK Targeting NIX/LC3 Axis.  |  Huang, CF., et al. 2023. Cells. 12: PMID: 36766737
  9. Protective effects of methyl protodioscin against lipid disorders and liver injury in hyperlipidemic gerbils.  |  Chen, X., et al. 2023. Heliyon. 9: e22785. PMID: 38089978
  10. NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin.  |  Zeng, Q., et al. 2024. Chin Med. 19: 60. PMID: 38589903

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Protodioscin, 5 mg

sc-391527
5 mg
$178.00