Prostaglandin G2 is the first intermediary in the COX pathway which is stable enough to be isolated and characterized - the C15 hydroperoxide of PGH2 (sc-201266). Under normal conditions, PGG2 is quickly metabolized by COX-1 and COX-2 to give PGH2, which is the main predecessor for the 2-series prostaglandins and thromboxanes - important mediators of biological functions. Prostaglandin G2 is an activator of NOS.
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