Molecular structure of Prostaglandin G2, CAS Number: 51982-36-6
Prostaglandin G2 (CAS 51982-36-6)
Alternate Names:
PGG2
Application:
Prostaglandin G2 is the first intermediary in the COX pathway which is stable enough to be isolated and characterized
CAS Number:
51982-36-6
Purity:
>95%
Molecular Weight:
368.5
Molecular Formula:
C20H32O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Prostaglandin G2 is the first intermediary in the COX pathway which is stable enough to be isolated and characterized - the C15 hydroperoxide of PGH2 (sc-201266). Under normal conditions, PGG2 is quickly metabolized by COX-1 and COX-2 to give PGH2, which is the main predecessor for the 2-series prostaglandins and thromboxanes - important mediators of biological functions. Prostaglandin G2 is an activator of NOS.
Prostaglandin G2 (CAS 51982-36-6) References
- Structural insights into the stereochemistry of the cyclooxygenase reaction. | Kiefer, JR., et al. 2000. Nature. 405: 97-101. PMID: 10811226
- Ifetroban sodium: an effective TxA2/PGH2 receptor antagonist. | Rosenfeld, L., et al. 2001. Cardiovasc Drug Rev. 19: 97-115. PMID: 11484065
- The productive conformation of prostaglandin G2 at the peroxidase site of prostaglandin endoperoxide H synthase: docking, molecular dynamics, and site-directed mutagenesis studies. | Chubb, AJ., et al. 2006. Biochemistry. 45: 811-20. PMID: 16411757
- Prostaglandin endoperoxide H synthases: peroxidase hydroperoxide specificity and cyclooxygenase activation. | Liu, J., et al. 2007. J Biol Chem. 282: 18233-18244. PMID: 17462992
- Studies on the reduction of endogenously generated prostaglandin G2 by prostaglandin H synthase. | Eling, TE., et al. 1991. J Biol Chem. 266: 12348-55. PMID: 1905721
- Formation of 6,15-diketoprostaglandin F1 alpha from prostaglandin G2 by bovine aortic endothelial cells. | Mayer, B., et al. 1987. Biochim Biophys Acta. 918: 209-16. PMID: 3032265
- Prostaglandin G2 levels during reaction of prostaglandin H synthase with arachidonic acid. | Kulmacz, RJ. 1987. Prostaglandins. 34: 225-40. PMID: 3118417
- Identification of novel arachidonic acid metabolites formed by prostaglandin H synthase. | Hecker, M., et al. 1987. Eur J Biochem. 169: 113-23. PMID: 3119336
- Higher oxidation states of prostaglandin H synthase. Rapid electronic spectroscopy detected two spectral intermediates during the peroxidase reaction with prostaglandin G2. | Dietz, R., et al. 1988. Eur J Biochem. 171: 321-8. PMID: 3123232
- Prostaglandin H synthase: distinct binding sites for cyclooxygenase and peroxidase substrates. | Marshall, PJ. and Kulmacz, RJ. 1988. Arch Biochem Biophys. 266: 162-70. PMID: 3140729
- Metabolomic Profiles of Bovine Mammary Epithelial Cells Stimulated by Lipopolysaccharide. | Huang, Y., et al. 2019. Sci Rep. 9: 19131. PMID: 31836784
- Cyclooxygenase-2 inhibition affects the expression of down syndrom cell adhesion molecule via interaction with metabotropic glutamate receptor 5. | Stachowicz, K., et al. 2022. J Physiol Pharmacol. 73: PMID: 36193971
- Free radical damage to sarcoplasmic reticulum of masseter muscle by arachidonic acid and prostaglandin G2. | Okabe, E., et al. 1982. Pharmacology. 25: 138-48. PMID: 6216488
- Spectral intermediates of prostaglandin hydroperoxidase. | Nastainczyk, W., et al. 1984. Eur J Biochem. 144: 381-5. PMID: 6436022
- Chemical and enzymatic transformations of prostaglandin endoperoxides: evidence for the predominance of the 15-hydroperoxy pathway. | Raz, A., et al. 1976. Eur J Biochem. 70: 89-96. PMID: 827437
Activator of:
NOS.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Prostaglandin G2, 25 µg | sc-205471 | 25 µg | $96.00 | |||
Prostaglandin G2, 50 µg | sc-205471A | 50 µg | $184.00 |