Prostaglandin G2

Prostaglandin G2 (CAS 51982-36-6)

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Synonym: PGG2
Application: The first intermediary in the COX pathway which is stable enough to be isolated and characterized
CAS Number: 51982-36-6
Purity: >95%
Molecular Weight: 368.5
Molecular Formula: C20H32O6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Prostaglandin G2 is the first intermediary in the COX pathway which is stable enough to be isolated and characterized - the C15 hydroperoxide of PGH2 (sc-201266). Under normal conditions, PGG2 is quickly metabolized by COX-1 and COX-2 to give PGH2, which is the main predecessor for the 2-series prostaglandins and thromboxanes - important mediators of biological functions. Prostaglandin G2 is an activator of NOS.


References

1. Kulmacz, R.J. 1987. Prostaglandins. 34: 225-240. PMID: 3118417
2. Eling, T.E., et al. 1991. J. Biol. Chem. 266: 12348-12355. PMID: 1905721
3. Liu, J., et al. 2007. J. Biol. Chem. 282: 18233-18244. PMID: 17462992

Physical State :
Liquid
Solubility :
Soluble in DMSO (~100 mg/ml), ethanol (~100 mg/ml), and PBS (pH 7.2) (~2 mg/ml).
Storage :
Store at -80° C
Boiling Point :
56° C
Refractive Index :
n20D 1.55 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
Transport :
UN 1090, Class 3, Packing group II
PubChem CID :
5280883
MDL Number :
MFCD00036971
EC Number :
200-662-2
SMILES :
CCCCCC(OO)/C=C/[C@H]1C2OOC(C2)C1C/C=C\CCCC(=O)O

Download SDS (MSDS)

Certificate of Analysis

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