PARP-1 (B-10): sc-74470. Western blot analysis of PARP-1 expression in untreated (A) and Phytosphingosine (sc-201385) treated (B) Jurkat whole cell lysates.
Phytosphingosine (CAS 554-62-1)
See product citations (4)
Alternate Names:
4-D-Hydroxysphinganine
Application:
Phytosphingosine is a sphingolipid signaling molecule
CAS Number:
554-62-1
Purity:
98%
Molecular Weight:
317.51
Molecular Formula:
C18H39NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Phytosphingosine is a sphingolipid endogenous to many organisms involved in cell signaling. Apoptosis is signaled by the presence of Phytosphingosine, with the induction of apoptosis accompanied by activation of caspase-8-mediated and mitochondrial activation-mediated apoptotic pathways. An increase in p38 MAPK phosphorylation is noted upon Phytosphingosine introduction, and a study describes two distinctly different p38 MAPK-mediated apoptotic pathways initiated by Phytosphingosine. The eukaryotic heat shock response also involves signaling with Phytosphingosine for activation of a ubiquitin protein degradation pathway.
Phytosphingosine (CAS 554-62-1) References
- The emerging role for sphingolipids in the eukaryotic heat shock response. | Jenkins, GM. 2003. Cell Mol Life Sci. 60: 701-10. PMID: 12785717
- Suppression of extracellular signal-related kinase and activation of p38 MAPK are two critical events leading to caspase-8- and mitochondria-mediated cell death in phytosphingosine-treated human cancer cells. | Park, MT., et al. 2003. J Biol Chem. 278: 50624-34. PMID: 14522966
- Phytosphingosine induced mitochondria-involved apoptosis. | Nagahara, Y., et al. 2005. Cancer Sci. 96: 83-92. PMID: 15723652
- Phytosphingosine derivatives ameliorate skin inflammation by inhibiting NF-κB and JAK/STAT signaling in keratinocytes and mice. | Kim, BH., et al. 2014. J Invest Dermatol. 134: 1023-1032. PMID: 24177187
- Phytosphingosine promotes megakaryocytic differentiation of myeloid leukemia cells. | Han, SH., et al. 2015. BMB Rep. 48: 691-5. PMID: 26077028
- Phytosphingosine Prevents the Formation of Young Salivary Biofilms in vitro. | Bikker, FJ., et al. 2018. Caries Res. 52: 7-13. PMID: 29232659
- Phytosphingosine is a novel activator of GPR120. | Nagasawa, T., et al. 2018. J Biochem. 164: 27-32. PMID: 29373685
- The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment. | Takahashi, M., et al. 2019. Sci Signal. 12: PMID: 30647146
- Effect of phytosphingosine on staining resistance and microhardness of tooth enamel. | Amorim, AA., et al. 2021. J Esthet Restor Dent. 33: 294-302. PMID: 32445541
- Engineering Yarrowia lipolytica for de novo production of tetraacetyl phytosphingosine. | Han, C., et al. 2021. J Appl Microbiol. 130: 1981-1992. PMID: 33190388
- The molecular mechanism of phytosphingosine binding to FFAR4/GPR120 differs from that of other fatty acids. | Nagasawa, T., et al. 2021. FEBS Open Bio. 11: 3081-3089. PMID: 34535977
- Phytosphingosine induces systemic acquired resistance through activation of sphingosine kinase. | Seo, SY., et al. 2021. Plant Direct. 5: e351. PMID: 34622122
- Phytosphingosine-induced cell apoptosis via a mitochondrially mediated pathway. | Li, J., et al. 2022. Toxicology. 482: 153370. PMID: 36334778
- Phytosphingosine inhibits cell proliferation by damaging DNA in human cell lines. | Sun, C., et al. 2023. Ecotoxicol Environ Saf. 256: 114840. PMID: 37001191
- Regulation of lipid biosynthesis in Saccharomyces cerevisiae by fumonisin B1. | Wu, WI., et al. 1995. J Biol Chem. 270: 13171-8. PMID: 7768913
Inhibitor of:
Cd1d1, Cd1d2, and Cldn27.Activator of:
9130409I23Rik, ASAH3, FIT2, GD3 Synthase, GPR92, Keratin 73, KRTAP5-4, LASS1, LASS3, LASS5, Lce1j, Lce1l, Measles H, MFSD2B, PIG-V, PNPLA1, PP2A-β, Sciellin, SMPD5, and Ypk2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phytosphingosine, 5 mg | sc-201385 | 5 mg | $100.00 | |||
Phytosphingosine, 25 mg | sc-201385A | 25 mg | $419.00 |