Phloridzin (CAS 60-81-1)

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Application: An SGLT-1 and SGLT-2 inhibitor found in apple trees
CAS Number: 60-81-1
Purity: 95%
Molecular Weight: 436.41
Molecular Formula: C21H24O10
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Phloridzin is a dihydrochalcone found in all parts of the apple tree, except the mature fruit, and acts as an inhibitor of SGLT-1 and SGLT-2.


1. Moelwyn-Hughes, J., et al.: Gen. Physiol., 13,807 (1930)
2. Bridel, K., et al.: Bull. Soc. Chim. Biol., 15, 544 (1933)

Physical State :
Solubility :
Soluble in DMSO (100 mM), methanol, acetone, ethanol (100 mM), and water (partly).
Storage :
Store at 4° C
Melting Point :
>126° C (dec.)
Boiling Point :
~770.0° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
SGLT-2: IC50 = 16 nM (human); COS-1 cells expressing hSGLT2: IC50 = 65 nM (human); SGLT-1: IC50 = 185 nM (human); COS-1 cells expressing hSGLT1: IC50 = 400 nM (human); Tyrosinase: IC50 = 110 µM (mushroom)
Ki Data :
SGLT2: Ki= 11 nM; SGLT1: Ki= 140 nM; CNT3: Ki= 16 µM; Tyrosinase: Ki= 64.3 µM (Agaricus bisporus); ENT1: Ki>1000 µM (human)
pK Values :
pKa: 7.15 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
EC Number :
Beilstein Registry :

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Certificate of Analysis

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