Phenacetin (CAS 62-44-2)
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Phenacetin is a compound with a history of use in various applications, it is studied for its biochemical properties and its environmental persistence. In analytical chemistry, it is frequently used as an internal standard for the quantification of other substances in complex mixtures via techniques like gas chromatography-mass spectrometry (GC-MS). In the field of environmental science, the pathways of Phenacetin degradation and its presence as a pollutant in water systems to better understand the environmental impact of such organic molecules. In the field of organic synthesis, Phenacetin role as a precursor in the preparation of other compounds through processes such as O-dealkylation. Studies on the metabolism of Phenacetin by various enzyme systems are conducted to gain insights into xenobiotic transformation and detoxification pathways in organisms.
Phenacetin (CAS 62-44-2) References
- Turpentine oil induced inflammation decreases absorption and increases distribution of phenacetin without altering its elimination process in rats. | Prasad, VG., et al. 2015. Eur J Drug Metab Pharmacokinet. 40: 23-8. PMID: 24356809
- Acetaminophen/paracetamol: A history of errors, failures and false decisions. | Brune, K., et al. 2015. Eur J Pain. 19: 953-65. PMID: 25429980
- Study of the ability of phenacetin, acetaminophen, and aspirin to induce cytotoxicity, mutation, and morphological transformation in C3H/10T1/2 clone 8 mouse embryo cells. | Patierno, SR., et al. 1989. Cancer Res. 49: 1038-44. PMID: 2912548
- Comparison of salicylamide and acetaminophen and their prodrug disposition in dogs. | Podder, SK., et al. 1988. J Pharmacobiodyn. 11: 324-9. PMID: 3171875
- An NIR-light-responsive surface molecularly imprinted polymer for photoregulated drug release in aqueous solution through porcine tissue. | Liu, LT., et al. 2020. Mater Sci Eng C Mater Biol Appl. 106: 110253. PMID: 31753332
- Combined hepatic arterial-portal venous and hepatic arterial-hepatic venous perfusions to probe the abundance of drug metabolizing activities: perihepatic venous O-deethylation activity for phenacetin and periportal sulfation activity for acetaminophen in the once-through rat liver preparation. | Pang, KS., et al. 1988. J Pharmacol Exp Ther. 247: 690-700. PMID: 3183964
- Thermodynamic Characteristics of Phenacetin in Solid State and Saturated Solutions in Several Neat and Binary Solvents. | Przybyłek, M., et al. 2021. Molecules. 26: PMID: 34279418
- Determination of CYP450 activities in diabetes mellitus rats by a UHPLC-MS/MS method. | Wang, Z., et al. 2023. J Pharm Biomed Anal. 224: 115191. PMID: 36512868
- Solubility Characteristics of Acetaminophen and Phenacetin in Binary Mixtures of Aqueous Organic Solvents: Experimental and Deep Machine Learning Screening of Green Dissolution Media. | Cysewski, P., et al. 2022. Pharmaceutics. 14: PMID: 36559321
- Inhibitory actions of desacetylation products of phenacetin and paracetamol on prostaglandin synthetases in neuronal and glial cell lines and rat renal medulla. | von Bruchlausen, F. and Baumann, J. 1982. Life Sci. 30: 1783-91. PMID: 6808277
- Metabolite kinetics: formation of acetaminophen from deuterated and nondeuterated phenacetin and acetanilide on acetaminophen sulfation kinetics in the perfused rat liver preparation. | Pang, KS., et al. 1982. J Pharmacol Exp Ther. 222: 14-9. PMID: 7086695
- The effect of propylene glycol on the P450-dependent metabolism of acetaminophen and other chemicals in subcellular fractions of mouse liver. | Snawder, JE., et al. 1993. Life Sci. 52: 183-9. PMID: 8355558
- Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2. | Tassaneeyakul, W., et al. 1993. J Pharmacol Exp Ther. 265: 401-7. PMID: 8474022
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phenacetin, 50 g | sc-257998 | 50 g | $47.00 | |||
Phenacetin, 250 g | sc-257998A | 250 g | $89.00 |