Molecular structure of Parthenolide, CAS Number: 20554-84-1
Parthenolide (CAS 20554-84-1)
See product citations (32)
Application:
Parthenolide is an inhibitor specifically inhibits HDAC1 without affecting other class I/II HDACs
CAS Number:
20554-84-1
Purity:
≥99%
Molecular Weight:
248.3
Molecular Formula:
C15H20O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. It is a sesquiterpene lactone, a class of plant terpenoids. Parthenolide has demonstrated anti-inflammatory activity. Parthenolide may act to inhibit the release of various chemical mediators such as Cox-2, TNF-alpha and IL-1 in LPS-stimulated macrophages and activation of MAP kinase and NFκbeta. Recent findings indicate that parthenolide binds to and directly inhibits IKK (Iκbeta kinase). The compound has also been shown to block the production of thromboxane B2 and leukotriene B4.
Parthenolide (CAS 20554-84-1) References
- Sensitivity and specificity of blood and thyroid radio-iodine assays for TSH and LATS and inhibitory effect of corticosteroid. | Sharard, A. 1975. N Z Med J. 81: 21-2. PMID: 1055309
- The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. | Kwok, BH., et al. 2001. Chem Biol. 8: 759-66. PMID: 11514225
- Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components. | Sumner, H., et al. 1992. Biochem Pharmacol. 43: 2313-20. PMID: 1319159
- Feverfew extracts and parthenolide irreversibly inhibit vascular responses of the rabbit aorta. | Barsby, RW., et al. 1992. J Pharm Pharmacol. 44: 737-40. PMID: 1360525
- A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro. | Groenewegen, WA. and Heptinstall, S. 1990. J Pharm Pharmacol. 42: 553-7. PMID: 1981582
- Parthenium dermatitis: is parthenolide an effective choice for patch testing? | Mahajan, VK., et al. 2014. Contact Dermatitis. 70: 340-3. PMID: 24617958
- Elucidation and in planta reconstitution of the parthenolide biosynthetic pathway. | Liu, Q., et al. 2014. Metab Eng. 23: 145-53. PMID: 24704560
- Parthenolide accumulation and expression of genes related to parthenolide biosynthesis affected by exogenous application of methyl jasmonate and salicylic acid in Tanacetum parthenium. | Majdi, M., et al. 2015. Plant Cell Rep. 34: 1909-18. PMID: 26183953
- Repressed Ca(2+) clearance in parthenolide-treated murine brain bEND.3 endothelial cells. | Tsai, TY., et al. 2015. Eur J Pharmacol. 769: 280-6. PMID: 26607466
- Determination of parthenolide in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study. | Zhao, AQ., et al. 2016. J Pharm Biomed Anal. 119: 99-103. PMID: 26678176
- Parthenolide ameliorates Concanavalin A-induced acute hepatitis in mice and modulates the macrophages to an anti-inflammatory state. | Wang, D., et al. 2016. Int Immunopharmacol. 38: 132-8. PMID: 27270078
- Efficacy of parthenolide on lung histopathology in a murine model of asthma. | Arıkan-Ayyıldız, Z., et al. 2017. Allergol Immunopathol (Madr). 45: 63-68. PMID: 27717727
- Protective effect of sesquiterpene lactone parthenolide on LPS-induced acute lung injury. | Jang, YJ., et al. 2016. Arch Pharm Res. 39: 1716-1725. PMID: 27757770
- Parthenolide suppresses pancreatic cell growth by autophagy-mediated apoptosis. | Liu, W., et al. 2017. Onco Targets Ther. 10: 453-461. PMID: 28176967
- Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases. | Hwang, D., et al. 1996. Biochem Biophys Res Commun. 226: 810-8. PMID: 8831694
Inhibitor of:
β-defensin 136, κB-Ras1, 2310079F23Rik, Abin-3, ACTR6, AFG3L1, AFX1, AIM2, ANKRD10, ANKRD29, APRIL-TWEAK, ASMTL, Bacteroides LPS, BAZ1A, Brn-3a, C. abortus LPS, C18orf37, C20orf96, C230096C10Rik, C5orf35, CARD 14, CARD 6, CARD 8, caspase-11, caspase-13, CBX6, CD32-B_Fc γ RIIb, CEP170, CLEC-4D, CRY1, Cytokeratin 14, Cytokeratin 18, Dexras1, Dnmt3a, DRP2, EG434219, EG624439, EG624584, Ep-CAM, FADD, FAM105B, FAT10, Fbxw12, FLJ42117, FOXD4L4, GAGE7B, gasdermin A2, gasdermin A3, gasdermin C, GRK 5, GSDMC2, GSTT2B, H2-Dk, H2-Eκ, H2-M1, H2afb2, H2al2y, HCFC1R1, hCG_1982709, hCG_2023776, hCG_40738, HDAC, HDAC1, HHV-4 LMP-1, HIC-2, Histone cluster 1 H1T, Histone cluster 1 H3G, Histone cluster 1 H3J, Histone cluster 1 H4K, Histone cluster 1 H4M, Histone H2B.S, Histone H3F3C, HIV vpr, hnRNP A1, HoxA4, HoxA7, HoxA9, HP1β, HRF, HSCARG_NMRAL1, HSZFP36, IκB-γ, IκB-ζ, IκB-pp40, ICE-LAP6, ICEBERG, IFIX, IFN-α16, IKIP, IKK, IKKγ, IL-1β, IL-1δ, IL-1ε F6, IL-17B, IL-17E, IL-18, IL-1F10, IL-1R9, IL-23, IL-28B, IL-32, IL-TIF, IL1F6, IL1R2, INO80D, IRAK-2, IRF-6, JMJD1A, Jumonji, KCNMB4, KIBRA, KRTAP16-4, KRTAP8-2, L3MBTL4, LAF4, LAPTM4B, LCE1E, Lce1g, LCE2B, Legionella pneumophila LPS, LGALS9C, LIR-7, LOC100040962, LOC390245, LOC646817, LURAP1L, LYSMD3, MALL, MAP-2B, MBD3L2-5, MBD3L3, MBD6, MCPIP, MD-1, MetAP-1, MILI, MUL1, NAIP1, NAIP2, NAIP5, NAIP6, NAIP7, NALP10, NALP13, NALP14, NALP1B, NALP4, NALP4A, NALP4B, NALP4C, NALP4f, NALP5, NALP6, NALP7, NALP8, NALP9, NALP9A, NALP9B, NALP9C, NDUFB8, nemo I, NF-1B, NF-1X, NFκB p50, NFκB p52, NFκB p65, NFKBIL1, NFKBIL2, NFRκB, NKG2-C, NKRF, Nlrp12, Olfr462, Olfr806, Olfr807, Olfr808, Olfr809, Olfr810, p100, p105, p8, pan 14-3-3, PCDHA1, PCDHA12, PCDHA2, PCDHA3, PCDHAC2_Pcdhac2, PCDHGA5, PCM1, PKC beta, PLAA, PLP-Cα, PRAME like-1, PRAMEF18, PRAMEF23, PRAMEF25, PRDM7, PRMT7, PSG8, PWWP2A, Pyhin1, PYPAF7, RelA, RelB, RELL1, RELT, RNF223, RUNX2, SCMH1, SerpinB9e, SIMPL, Smurf2, SMYD1, SMYD2, SPATA2, SUZ12, T2R09, T2R14, T2R16, T2R24, T2R42, T2R48, T2R9, TALL-1, TANK, Tenr, TET2, THP, TICAM-2, TLR1, TM6SF2, TNF Superfamily (TNFSF), TNF-R2, TNFα-IP 1, TNFβ, TNIP2 (Abin-2), TRADD, TRAFD1, TRIM30, TRIM30A, TRIM56, TSHZ3, TSPY8, TSSC3, TTP, TWEAK, TXNDC13, TXNL6, USF-2, V1RF1, VEGI, VSTM4, WDR38, YB-1, ZBTB38, ZHX1, ZNF263, ZNF580, ZNF644, ZNF645, ZNF683, and ZNF827.Activator of:
δ-tubulin, γ1 Tubulin, κB-Ras1, 14-3-3 θ, 3 BP-1, 3830417A13Rik, 5-Methylcytidine, Abin-1, ANKT, ASH2L, Baxα, BAZ2A, BC006662, BRMS1, BRPF3, C1orf105, C3orf30, CD30, CD48, Centaurin β5, CGBP, CSMD1, CYLD, DCIR, Dimethyl Histone H3, Dmap1, DPPA2, DPY-30, E(z), EG623459, EMID2, ERK 5, Ets-1, EZHIP, FAF1, FAM208A, FBL11, FKBP51, FLIPL, FOXK1, FRBZ1, GAGE13, GAGE7B, GATAD2A, Glrp-1, H2afb2, H2BFWT, HEATR3, Histone cluster 1 H2AC, Histone cluster 1 H2AI, Histone cluster 1 H2BB, Histone cluster 1 H2BC, Histone cluster 1 H2BI, Histone cluster 1 H3A, Histone cluster 1 H3D, Histone cluster 1 H3E, Histone cluster 1 H3I, Histone cluster 1 H4F, Histone cluster 1 H4L, Histone cluster 2 H2AA3, Histone cluster 2 H2BE, Histone cluster 2 H3A, Histone cluster 2 H3C, Histone cluster 3 H3, HMG-17, HP1γ, HSPC038, HTR3E, IκB-α, IκB-β, IκB-δ, IκB-γ, IκB-pp40, Ihh, IL-18BP, IL-1F8, IL-34, ING4, Integrin βL1, IRAK-M, Jade-1, JMJD2D, JMJD4, Khdc1b, kismet, KLF16, KRBOX1, LEUTX, LOC100041215, LOC100041244, LOC646817, MAGE-D4B, MBD3L2, MBD3L4, MBD6, megalin, Menin, MLL, MLL3, Monomethyl Histone H4, Morc1, MSL-1, N28178, NALP11, NALP9C, Nanog, NAP1L1, NAP1L2, NAP1L5, NBK, NBPF3, NF-1C, NKRF, OSTM1, Ox40L, PCGF1, PHC1, PHF12, PIASx, PRAME like-3, PRAME like-6, PRAME like-7, PRAMEF12, PRAMEF16, PRAMEF20, PRDM5, PWWP2B, Pyrin, RASSF1F, RBA-1, RBBP1, RBM10, RELL1, RFPL2, RNF123, RNF175, RPA 32 kDa subunit, SATL1, Set2, SFMBT1, SHARPIN, SUMO-3, SUV420H1, T2R10, T2R13, T2R14, T2R21, T2R3, T2R43, T2R45, T2R47, T2R50, T2R60, T2R7, T2R9, TAB3, Tas2r102, Tas2r114, Tas2r140, TDRD5, THAP10, Tiam1, TIGD4, TIGD5, TMPRSS2, TNFα-IP 2, TNFα-IP 8L3, Tnfrsf26, Tollip, TRAF7, TREML1, TRIM35, TRIM40, TRIM6, Trimethyl Histone H4, TRUNDD, USP11, UTY, UXT, VPS72, VSIG8, VSTM1, WHIP, WIZ, XAGE-1, ZBTB6, ZNF222, ZNF671, ZNF709, and ZSWIM6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Parthenolide, 50 mg | sc-3523 | 50 mg | $79.00 | |||
Parthenolide, 250 mg | sc-3523A | 250 mg | $300.00 |