Paromomycin Sulfate An aminoglycoside antibiotic

Paromomycin Sulfate (CAS 1263-89-4)

Synonym: Aminosidin sulfate; Gabbroral; Aminoxidin; Farmiglucin; Humagel; Humatin; Pargonyl; Sinosid; D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1- >4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)- beta-D-ribofuranosyl-(1->5))-2-deoxy-, sulfate (salt)
Application: An aminoglycoside antibiotic
CAS Number: 1263-89-4
Molecular Weight: 713.71
Molecular Formula: C23H45N5O14.H2SO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Paromomycin Sulfate is an aminoglycoside antibiotic.


References

Konno T, Takahashi T, Muto A et al. Nucleic Acids Res Suppl. (3):235-6 (2003). Lando D, Cousin MA, Ojasoo T et al. Eur J Biochem. 66:597-606 (1976).

Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml).
Storage :
Store at room temperature
Refractive Index :
n20D ~1.68 (Predicted)
Optical Activity :
α20D +51°, c = 5 in water
IC50 :
Inhibition of ribosome S30 subunit-mediated protein synthesis : IC50 = 50 nM (Escherichia coli); Inhibition of protein translation: IC50 = 56 nM (Escherichia coli); Nucleic Acid: IC50 = 600 nM; Antimicrobial activity against Cryptosporidium parvum infected in human HCT-8 cells: IC50 = 711 nM; Inhibition of ribosome-mediated protein synthesis: IC50 = 57 µM (rabbit reticulocytes )
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
WK2320000
PubChem CID :
441375
Merck Index :
14: 7041
MDL Number :
MFCD00079278
EC Number :
215-031-7
Beilstein Registry :
5715182
SMILES :
C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O

Download SDS (MSDS)

Certificate of Analysis

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