PalGly (CAS 2441-41-0)

Palmitoyl glycine (PalGly) is a lipid-amino acid conjugate extensively studied for its role in cell signaling and membrane interactions. This molecule consists of palmitic acid, a saturated long-chain fatty acid, linked to glycine, an amino acid. PalGly is part of a broader class of lipid-modified amino acids and peptides that modulate various biological functions by incorporating into cell membranes and influencing membrane-associated processes. In research, PalGly is used to explore its effects on membrane fluidity and the organization of lipid microdomains. Its amphiphilic nature allows it to integrate into lipid bilayers, potentially altering the physical properties of membranes and affecting the activity of membrane-bound proteins, including receptors and enzymes. PalGly also serves as a model compound for investigating the biochemical mechanisms underlying lipid-protein interactions. Researchers utilize this molecule to study how lipid modifications can affect protein localization, stability, and function. Furthermore, PalGly is employed in the development of novel biomaterials and drug delivery systems. Its ability to enhance the bioavailability and stability of agents makes it a valuable component in the formulation of lipid-based delivery vehicles. Overall, PalGly is a critical tool in lipidomics and cell biology, advancing our understanding of lipid-mediated signaling and membrane dynamics.