Date published: 2025-11-20

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Ochratoxin A (CAS 303-47-9)

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Alternate Names:
N-[(3R)-(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-L-phenylalanine; OCA
Application:
Ochratoxin A is a nephrotoxic mycotoxin inhibitor of phenylalanyl-tRNA synthetases
CAS Number:
303-47-9
Purity:
≥98%
Molecular Weight:
403.81
Molecular Formula:
C20H18ClNO6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ochratoxin A is a mycotoxin produced by certain species of Aspergillus and Penicillium fungi that is found in a variety of food commodities, including cereals, coffee, dried fruit, and wine. In research, Ochratoxin A is extensively studied for its impact on cellular and molecular processes. Studies focus on its mechanism of toxicity, which includes the inhibition of phenylalanine-tRNA synthetase, leading to disruptions in protein synthesis and cellular metabolism. Additionally, Ochratoxin A is used in the development of detection methods for food safety analysis, aiming to identify and quantify its presence in foodstuffs to minimize exposure. Research on Ochratoxin A also explores its role in oxidative stress and the induction of DNA damage, contributing to a broader understanding of the molecular basis of mycotoxin-induced toxicity.


Ochratoxin A (CAS 303-47-9) References

  1. Alterations in ATP-dependent calcium uptake by rat renal cortex microsomes following ochratoxin A administration in vivo or addition in vitro.  |  Chong, X. and Rahimtula, AD. 1992. Biochem Pharmacol. 44: 1401-9. PMID: 1417961
  2. Mechanism of action of ochratoxin A.  |  Dirheimer, G. and Creppy, EE. 1991. IARC Sci Publ. 171-86. PMID: 1820332
  3. Ochratoxin A producing species in the genus Penicillium.  |  Cabañes, FJ., et al. 2010. Toxins (Basel). 2: 1111-20. PMID: 22069629
  4. Ochratoxin A and ochratoxin-producing fungi on cereal grain in China: a review.  |  Zhihong, L., et al. 2015. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 32: 461-70. PMID: 25571918
  5. Ochratoxin A in liquorice products - a review.  |  Khalesi, M. 2015. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 32: 2086-92. PMID: 26374697
  6. Immunohistochemical Review of Leydig Cell Lesions in Ochratoxin A-Treated Fischer Rats and Controls.  |  Herman, D. and Mantle, P. 2019. Toxins (Basel). 11: PMID: 31434192
  7. The Occurrence and Contamination Level of Ochratoxin A in Plant and Animal-Derived Food Commodities.  |  Li, X., et al. 2021. Molecules. 26: PMID: 34834020
  8. Ochratoxin A and 2'R-Ochratoxin A in Selected Foodstuffs and Dietary Risk Assessment.  |  Zapaśnik, A., et al. 2021. Molecules. 27: PMID: 35011417
  9. Ochratoxin A in Slaughtered Pigs and Pork Products.  |  Vlachou, M., et al. 2022. Toxins (Basel). 14: PMID: 35202095
  10. Biomonitoring of ochratoxin A, 2'R-ochratoxin A and citrinin in human blood serum from Switzerland.  |  Jaus, A., et al. 2022. Mycotoxin Res. 38: 147-161. PMID: 35446004
  11. The relationship between ochratoxin A and blood pressure in adolescents.  |  Erdal, İ. and Yalçın, SS. 2022. Environ Toxicol Pharmacol. 95: 103959. PMID: 35987497
  12. Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh.  |  van der Merwe, KJ., et al. 1965. Nature. 205: 1112-3. PMID: 5833211
  13. Effect of superoxide dismutase and catalase on the nephrotoxicity induced by subchronical administration of ochratoxin A in rats.  |  Baudrimont, I., et al. 1994. Toxicology. 89: 101-11. PMID: 8197587
  14. Induction of free radicals in hepatocytes, mitochondria and microsomes of rats by ochratoxin A and its analogs.  |  Hoehler, D., et al. 1997. Biochim Biophys Acta. 1357: 225-33. PMID: 9223626
  15. Effects of ochratoxin A on DNA repair in cultures of rat hepatocytes and porcine urinary bladder epithelial cells.  |  Dörrenhaus, A. and Föllmann, W. 1997. Arch Toxicol. 71: 709-13. PMID: 9363845

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ochratoxin A, 1 mg

sc-202749
1 mg
$106.00

Ochratoxin A, 5 mg

sc-202749A
5 mg
$332.00

Ochratoxin A, 25 mg

sc-202749B
25 mg
$1234.00