Molecular structure of Noscapine, CAS Number: 128-62-1
Noscapine (CAS 128-62-1)
Alternate Names:
(3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone
Application:
Noscapine is a centrally acting antitussive agent
CAS Number:
128-62-1
Purity:
≥99%
Molecular Weight:
413.42
Molecular Formula:
C22H23NO7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Noscapine is extensively used in research focused on cell division and microtubule dynamics. As a non-narcotic compound found in opium poppy, it serves as an important tool for studying the mitotic spindle apparatus in cell biology. Researchers utilize Noscapine to investigate its binding properties with tubulin, analyzing how it affects tubulin polymerization and ultimately influences cell division processes. This application is for understanding the mechanisms that control cell proliferation and stability. Additionally, Noscapine is involved in studies aimed at elucidating the molecular pathways of microtubule assembly and disassembly, providing insights that are fundamental for the development of novel strategies to study cellular structures and functions.
Noscapine (CAS 128-62-1) References
- Noscapine recirculates enterohepatically and induces self-clearance. | Mukkavilli, R., et al. 2015. Eur J Pharm Sci. 77: 90-9. PMID: 26026989
- Noscapine protects OLN-93 oligodendrocytes from ischemia-reperfusion damage: Calcium and nitric oxide involvement. | Nadjafi, S., et al. 2015. Acta Physiol Hung. 102: 351-62. PMID: 26690027
- Noscapine inhibits human hepatocellular carcinoma growth through inducing apoptosis in vitro and in vivo. | Xu, G., et al. 2016. Neoplasma. 63: 726-33. PMID: 27468876
- Overcoming P-Glycoprotein-Mediated Drug Resistance with Noscapine Derivatives. | Muthiah, D., et al. 2019. Drug Metab Dispos. 47: 164-172. PMID: 30478158
- Imidazo[2,1-b]thiazole-Coupled Natural Noscapine Derivatives as Anticancer Agents. | Nagireddy, PKR., et al. 2019. ACS Omega. 4: 19382-19398. PMID: 31763563
- Noscapine, a possible drug candidate for attenuation of cytokine release associated with SARS-CoV-2. | Ebrahimi, SA. 2020. Drug Dev Res. 81: 765-767. PMID: 32337769
- Noscapine protects the H9c2 cardiomyocytes of rats against oxygen-glucose deprivation/reperfusion injury. | Vahabzadeh, G., et al. 2020. Mol Biol Rep. 47: 5711-5719. PMID: 32648076
- Structural Basis of Noscapine Activation for Tubulin Binding. | Oliva, MA., et al. 2020. J Med Chem. 63: 8495-8501. PMID: 32657585
- Antitussive noscapine and antiviral drug conjugates as arsenal against COVID-19: a comprehensive chemoinformatics analysis. | Kumar, N., et al. 2022. J Biomol Struct Dyn. 40: 101-116. PMID: 32815796
- Noscapine alleviates cerebral damage in ischemia-reperfusion injury in rats. | Kawadkar, M., et al. 2021. Naunyn Schmiedebergs Arch Pharmacol. 394: 669-683. PMID: 33106921
- Noscapine Acts as a Protease Inhibitor of In Vitro Elastase-Induced Collagen Deposition in Equine Endometrium. | Amaral, A., et al. 2021. Int J Mol Sci. 22: PMID: 34069423
- Noscapine Prevents Rotenone-Induced Neurotoxicity: Involvement of Oxidative Stress, Neuroinflammation and Autophagy Pathways. | Jayaraj, RL., et al. 2021. Molecules. 26: PMID: 34361780
- 9-Ethynyl noscapine induces G2/M arrest and apoptosis by disrupting tubulin polymerization in cervical cancer. | Nagireddy, PKR., et al. 2022. Drug Dev Res. 83: 605-614. PMID: 34612529
- Topical Formulation of Noscapine, a Benzylisoquinoline Alkaloid, Ameliorates Imiquimod-Induced Psoriasis-Like Skin Lesions. | Nourbakhsh, F., et al. 2022. Evid Based Complement Alternat Med. 2022: 3707647. PMID: 35497929
- Are noscapine and raloxifene ligands of the bradykinin B2 receptor? An assessment based on the human umbilical vein contractility assay. | Bachelard, H. and Marceau, F. 2022. Int Immunopharmacol. 110: 108984. PMID: 35780642
Inhibitor of:
β1 Tubulin, δ-tubulin, ARL6, ARMC2, Bradykinin B Receptor, CapG, CLIP-115, CSAP, DNCLI1, GAGE12B, Hippi, Katanin p80 BL1, MAP-7, MFAP1B, mKIAA1853, Odf3l2, SPAG16, TBCD, Tctex1D2, Tctex2, TNP2, TPPP2, TULP2, and TULP4.Activator of:
α3e Tubulin, β5 Tubulin, ε Tubulin, 1700001P01Rik, 1700019B03Rik, EG231836, Katanin p80 B1, KIF4, MARK1, MTUS1, NEDD1, SPAG5, TBCA, and TBCE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Noscapine, 10 mg | sc-219418 | 10 mg | $102.00 |