Nisin from Lactococcus lactis (CAS 1414-45-5)

Nisin from Lactococcus lactis is a natural antimicrobial peptide. This lantibiotic peptide, derived from specific bacteria strains like Lactococcus lactis, effectively impedes the growth of various Gram-positive bacteria, including food-borne pathogens. Composed of 34 amino acids, Nisin from Lactococcus lactis is produced through bacterial fermentation. It demonstrates multiple mechanisms of action, including disrupting the cell membrane, inhibiting cell wall synthesis, and impeding protein synthesis. Additionally, Nisin from Lactococcus lactis induces the production of specific enzymes, such as proteases, facilitating the breakdown of bacterial cell walls. Its mode of action involves binding to cell wall precursor lipid components (lipid A portion) of bacteria and disrupts cell wall production. This binding prompts a conformational change known as the "nisin effect," leading to the inhibition of bacterial growth. Moreover, it alters the cell membrane which results in the leakage of cytoplasmic components and destruction of the proton motive force1.