Molecular structure of N-tert-Butyl-a-phenylnitrone, CAS Number: 3376-24-7
N-tert-Butyl-a-phenylnitrone (CAS 3376-24-7)
Application:
N-tert-Butyl-a-phenylnitrone is a Cox-2 inhibitor
CAS Number:
3376-24-7
Purity:
98%
Molecular Weight:
177.25
Molecular Formula:
C11H15NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-tert-Butyl-a-phenylnitrone is a commonly-used free radical trap. It contains radical scavenging activity and an ability to inhibit Cox-2 (cyclooxygenase-2). N-tert-Butyl-a-phenylnitrone is an antioxidant that may act to act as a protective agent in several experimental models of neurodegenerative disorders. N-tert-Butyl-a-phenylnitrone inhibits lipid peroxidation in rat liver microsomes. It also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.
N-tert-Butyl-a-phenylnitrone (CAS 3376-24-7) References
- Nitric oxide modulates high-energy phosphates in brain regions of rats intoxicated with diisopropylphosphorofluoridate or carbofuran: prevention by N-tert-butyl-alpha-phenylnitrone or vitamin E. | Gupta, RC., et al. 2001. Arch Toxicol. 75: 346-56. PMID: 11570692
- Protective effect of spin trap agent, N-tert-butyl-alpha-phenylnitrone on hyperoxia-induced oxidative stress and its potential as a nitric oxide donor. | Saito, K. and Yoshioka, H. 2002. Free Radic Res. 36: 143-9. PMID: 11999381
- ESR characterization of a novel spin-trapping agent, 15N-labeled N-tert-butyl-alpha-phenylnitrone, as a nitric oxide donor. | Saito, K. and Yoshioka, H. 2002. Biosci Biotechnol Biochem. 66: 2189-93. PMID: 12450131
- Paraquat-induced lung injury: prevention by N-tert-butyl-alpha-phenylnitrone, a free-radical spin-trapping agent. | Sata, T., et al. 1992. Am J Physiol. 262: L147-52. PMID: 1311515
- Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone. | Carney, JM., et al. 1991. Proc Natl Acad Sci U S A. 88: 3633-6. PMID: 1673789
- In vivo or in vitro administration of the nitrone spin-trapping compound, n-tert-butyl-alpha-phenylnitrone, (PBN) reduces age-related deficits in striatal muscarinic receptor sensitivity. | Joseph, JA., et al. 1995. Brain Res. 671: 73-7. PMID: 7728535
- N-tert-butyl-alpha-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia. | Folbergrová, J., et al. 1995. Proc Natl Acad Sci U S A. 92: 5057-61. PMID: 7761448
- The effects of chronic treatment with N-tert-butyl-alpha-phenylnitrone on cerebellar noradrenergic receptor function in aged F344 rats. | Gould, TJ. and Bickford, PC. 1994. Brain Res. 660: 333-6. PMID: 7820702
- Prevention of ischemia/reperfusion-induced alterations in synaptosomal membrane-associated proteins and lipids by N-tert-butyl-alpha-phenylnitrone and difluoromethylornithine. | Hall, NC., et al. 1995. Neuroscience. 69: 591-600. PMID: 8552252
- Effect of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone on protein oxidation and life span. | Dubey, A., et al. 1995. Arch Biochem Biophys. 324: 249-54. PMID: 8554316
- Prevention of hyperoxia-induced alterations in synaptosomal membrane-associated proteins by N-tert-butyl-alpha-phenylnitrone and 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (Tempol). | Howard, BJ., et al. 1996. J Neurochem. 67: 2045-50. PMID: 8863512
- Melatonin and N-tert-butyl-alpha-phenylnitrone block 60-Hz magnetic field-induced DNA single and double strand breaks in rat brain cells. | Lai, H. and Singh, NP. 1997. J Pineal Res. 22: 152-62. PMID: 9213269
- Release of nitric oxide from a spin trap, N-tert-butyl-alpha-phenylnitrone, under various oxidative conditions. | Saito, K., et al. 1998. Biol Pharm Bull. 21: 401-4. PMID: 9586581
Inhibitor of:
Cox-2, Enzyme, and SOD-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-tert-Butyl-a-phenylnitrone, 500 mg | sc-202722 | 500 mg | $51.00 | |||
N-tert-Butyl-a-phenylnitrone, 1 g | sc-202722A | 1 g | $87.00 |