Molecular structure of N-Acetylneuraminic acid, CAS Number: 131-48-6
N-Acetylneuraminic acid (CAS 131-48-6)
Alternate Names:
N-Acetylneuraminic acid is also known as NANA.
Application:
N-Acetylneuraminic acid is the predominant mammalian sialic acid, mostly abundant in bacteria as well as in eukaryotic cells.
CAS Number:
131-48-6
Purity:
≥98%
Molecular Weight:
309.30
Molecular Formula:
C11H19NO9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
N-Acetylneuraminic acid is a sialic acid nine-carbon monosaccharide found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells. Studies suggest that N-Acetylneuraminic acid is useful biologically in neurotransmission, leukocyte extravasation, viral or bacterial infections and carbohydrate-protein recognition. It is believed that N-Acetylneuraminic acid, a negatively charged, non-reducing sugar, is more difficult to analyze directly. One method for its detection in serum is to cleave pyruvic acid from the molecule via N-Acetylneuraminic acid aldolase followed by colorimetric detection.
N-Acetylneuraminic acid (CAS 131-48-6) References
- Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. | AMINOFF, D. 1961. Biochem J. 81: 384-92. PMID: 13860975
- PLGA nanoparticles surface decorated with the sialic acid, N-acetylneuraminic acid. | Bondioli, L., et al. 2010. Biomaterials. 31: 3395-403. PMID: 20132980
- Bioengineering of bacterial polymer inclusions catalyzing the synthesis of N-acetylneuraminic acid. | Hooks, DO., et al. 2013. Appl Environ Microbiol. 79: 3116-21. PMID: 23455347
- N-acetylneuraminic acid and N-glycolylneuraminic acid in glycopeptides of colonic tumor and mucosa in rats treated with carrageenan and 1,2-dimethylhydrazine. | Arakawa, S., et al. 1989. Biochem Biophys Res Commun. 159: 452-6. PMID: 2930522
- Chemical Synthesis of Glycosides of N-Acetylneuraminic Acid. | De Meo, C. and Jones, BT. 2018. Adv Carbohydr Chem Biochem. 75: 215-316. PMID: 30509401
- Synthesis of 4-O-Alkylated N-Acetylneuraminic Acid Derivatives. | Johansson, E., et al. 2021. J Org Chem. 86: 9145-9154. PMID: 34138565
- Engineering of Synthetic Multiplexed Pathways for High-Level N-Acetylneuraminic Acid Bioproduction. | Zhang, X., et al. 2021. J Agric Food Chem. 69: 14868-14877. PMID: 34851104
- Selective Anticancer Materials by Self-Assembly of Synthetic Amphiphiles Based on N-Acetylneuraminic Acid. | Hwang, J., et al. 2022. ACS Appl Mater Interfaces. 14: 16100-16107. PMID: 35377593
- N-acetylneuraminic acid and chondroitin sulfate modified nanomicelles with ROS-sensitive H2S donor via targeting E-selectin receptor and CD44 receptor for the efficient therapy of atherosclerosis. | Chen, Q., et al. 2022. Int J Biol Macromol. 211: 259-270. PMID: 35513096
- The influence of N-acetylneuraminic acid on the properties of human orosomucoid. | Friedman, ML., et al. 1986. Biochem J. 236: 149-53. PMID: 3790067
- Accumulation of N-acetylneuraminic acid (sialic acid) in human fibroblasts cultured in the presence of N-acetylmannosamine. | Thomas, GH., et al. 1985. Biochim Biophys Acta. 846: 37-43. PMID: 4016156
- Metabolism of 4-O-methyl-N-acetylneuraminic acid a synthetic sialic acid. | Beau, JM. and Schauer, R. 1980. Eur J Biochem. 106: 531-40. PMID: 6156826
- Synthesis of N-acetylneuraminic acid and of CMP-N-acetylneuraminic acid in the rat liver cell. | Ferwerda, W., et al. 1983. Biochem J. 216: 87-92. PMID: 6651781
Inhibitor of:
COLEC10, Siglec-6, Siglec-9, ST8Sia IV, and ST8Sia VI.Activator of:
β3Gn-T5, C2, CLEC-18A, FucT-l, Ganglioside GD3, GCNT3, GM2/GD2 Synthase, GM3 Synthase, GnT-IVA, IGLON5, Influenza B, Neu1, Neuramidase, from V. cholerae, Neuraminidase, from C. perfringens, SerpinB8, SIAE, Sialyl Lewis a, Siglec-1, Siglec-10, ST8Sia V, and Streptolysin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Acetylneuraminic acid, 1 g | sc-281055A | 1 g | $82.00 | |||
N-Acetylneuraminic acid, 5 g | sc-281055 | 5 g | $153.00 | |||
N-Acetylneuraminic acid, 25 g | sc-281055D | 25 g | $320.00 | |||
N-Acetylneuraminic acid, 100 g | sc-281055B | 100 g | $572.00 | |||
N-Acetylneuraminic acid, 250 g | sc-281055C | 250 g | $1336.00 |