Date published: 2025-11-16

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N-Acetyl-L-methionine (CAS 65-82-7)

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CAS Number:
65-82-7
Molecular Weight:
191.25
Molecular Formula:
C7H13NO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N-Acetyl-L-methionine is a derivative of the amino acid methionine. It serves as a precursor for the synthesis of S-adenosyl-L-methionine (SAMe), a key methyl donor in various biochemical reactions. N-Acetyl-L-methionine is involved in the methylation of DNA, RNA, proteins, and lipids, playing a role in the regulation of gene expression and protein function. It also participates in the synthesis of polyamines, which are useful for cell growth and proliferation. At the cellular level, N-Acetyl-L-methionine contributes to the maintenance of redox balance and the detoxification of reactive oxygen species. It is involved in the regulation of neurotransmitter levels and the modulation of synaptic plasticity in the central nervous system.


N-Acetyl-L-methionine (CAS 65-82-7) References

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  2. Potential roles of flavin-containing monooxygenases in sulfoxidation reactions of l-methionine, N-acetyl-l-methionine and peptides containing l-methionine.  |  Elfarra, AA. and Krause, RJ. 2005. Biochim Biophys Acta. 1703: 183-9. PMID: 15680226
  3. Effects of geometric isomerism in dinuclear antitumor platinum complexes on their interactions with N-acetyl-L-methionine.  |  Oehlsen, ME., et al. 2005. J Biol Inorg Chem. 10: 433-42. PMID: 16091934
  4. Molecular cloning and biochemical characterization of L-N-carbamoylase from Sinorhizobium meliloti CECT4114.  |  Martínez-Rodríguez, S., et al. 2005. J Mol Microbiol Biotechnol. 9: 16-25. PMID: 16254442
  5. Bis-pentafluorobenzyl derivatives of N-acetyl-L-methionine and N-acetyl-L-selenomethionine for the quantitative determination in human plasma by gas chromatography-negative ion chemical ionisation mass spectrometry.  |  Leis, HJ., et al. 2012. J Chromatogr A. 1242: 92-100. PMID: 22552200
  6. N-acetyl-l-methionine is a superior protectant of human serum albumin against photo-oxidation and reactive oxygen species compared to N-acetyl-L-tryptophan.  |  Kouno, Y., et al. 2014. Biochim Biophys Acta. 1840: 2806-12. PMID: 24769178
  7. N-acetyl-L-methionine is a superior protectant of human serum albumin against post-translational oxidation as compared to N-acetyl-L-tryptophan.  |  Kouno, Y., et al. 2016. Biochem Biophys Rep. 6: 266-274. PMID: 28955884
  8. Production effects and bioavailability of N-acetyl-l-methionine in lactating dairy cows.  |  Räisänen, SE., et al. 2022. J Dairy Sci. 105: 313-328. PMID: 34756433
  9. Lactational performance of dairy cows in response to supplementing N-acetyl-l-methionine as source of rumen-protected methionine.  |  Amaro, FX., et al. 2022. J Dairy Sci. 105: 2301-2314. PMID: 34955263
  10. Portal and vena caval plasma methionine concentrations in young pigs administered L-methionine, N-acetyl-L-methionine and N-acetyl-D-methionine.  |  Daabees, TT., et al. 1984. J Nutr. 114: 1541-7. PMID: 6470816
  11. Plasma methionine levels in normal adult subjects after oral loading with L-methionine and N-acetyl-L-methionine.  |  Stegink, LD., et al. 1980. J Nutr. 110: 42-9. PMID: 7354384
  12. Effects of excess dietary l-methionine and N-acetyl-l-methionine on growing rats.  |  Rotruck, JT. and Boggs, RW. 1977. J Nutr. 107: 357-62. PMID: 845673
  13. Nitrogen retention in men fed isolated soybean protein supplemented with L-methionine, D-methionine, N-acetyl-L-methionine, or inorganic sulfate.  |  Zezulka, AY. and Calloway, DH. 1976. J Nutr. 106: 1286-91. PMID: 986424

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-Acetyl-L-methionine, 5 g

sc-228660
5 g
$39.00