Molecular structure of N-Acetyl-L-cysteine, CAS Number: 616-91-1
N-Acetyl-L-cysteine (CAS 616-91-1)
See product citations (34)
Alternate Names:
N-Acetyl-L-cysteine is also known as NAC.
Application:
N-Acetyl-L-cysteine is an antioxidant mucolytic acetylated amino acid that acts as a glutathione precursor compound.
CAS Number:
616-91-1
Purity:
≥98%
Molecular Weight:
163.19
Molecular Formula:
C5H9NO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N-Acetyl-L-cysteine is often utilized in research applications as a powerful antioxidant and a substrate in the study of glutathione metabolism. Its ability to replenish intracellular levels of glutathione makes it valuable in investigations concerning oxidative stress and cellular defense mechanisms. In the field of toxicology, N-Acetyl-L-cysteine is used to study various toxins and environmental stresses. Additionally, researchers use this compound to explore its role in modulating inflammatory responses and in the mechanics of mucus production in respiratory cells. It is also a common agent in studies related to neuroprotection, where its potential effects relating to oxidative damage are of interest.
N-Acetyl-L-cysteine (CAS 616-91-1) References
- The effect of glutathione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock. | Ortolani, O., et al. 2000. Am J Respir Crit Care Med. 161: 1907-11. PMID: 10852765
- Downregulation of XIAP and induction of apoptosis by the synthetic cyclin-dependent kinase inhibitor GW8510 in non-small cell lung cancer cells. | Dong, F., et al. 2006. Cancer Biol Ther. 5: 165-70. PMID: 16322690
- High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis. | Tirouvanziam, R., et al. 2006. Proc Natl Acad Sci U S A. 103: 4628-33. PMID: 16537378
- Reverse mutational analysis reveals threonine-373 as a potentially sufficient phosphorylation site for inactivation of the retinoblastoma tumor suppressor protein (pRB). | Lents, NH., et al. 2006. Cell Cycle. 5: 1699-707. PMID: 16880741
- GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity. | Fomina-Yadlin, D., et al. 2012. PLoS One. 7: e28808. PMID: 22242153
- Functional Module Connectivity Map (FMCM): a framework for searching repurposed drug compounds for systems treatment of cancer and an application to colorectal adenocarcinoma. | Chung, FH., et al. 2014. PLoS One. 9: e86299. PMID: 24475102
- Gemcitabine resistance mediated by ribonucleotide reductase M2 in lung squamous cell carcinoma is reversed by GW8510 through autophagy induction. | Chen, P., et al. 2018. Clin Sci (Lond). 132: 1417-1433. PMID: 29853661
- Acquired tamoxifen resistance is surmounted by GW8510 through ribonucleotide reductase M2 downregulation-mediated autophagy induction. | Li, ZN., et al. 2020. Biochem Biophys Res Commun. 528: 554-560. PMID: 32505349
- Identification of diagnostic and prognostic biomarkers, and candidate targeted agents for hepatitis B virus-associated early stage hepatocellular carcinoma based on RNA-sequencing data. | Zeng, Z., et al. 2020. Oncol Lett. 20: 231. PMID: 32968453
- Construction of the prognostic enhancer RNA regulatory network in osteosarcoma. | Yan, P., et al. 2022. Transl Oncol. 25: 101499. PMID: 36001923
- N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. | Ferrari, G., et al. 1995. J Neurosci. 15: 2857-66. PMID: 7722634
- Identification of N-acetylcysteine as a new substrate for rat liver microsomal glutathione transferase. A study of thiol ligands. | Weinander, R., et al. 1994. J Biol Chem. 269: 71-6. PMID: 8276873
- Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells. | Tsai, JC., et al. 1996. J Biol Chem. 271: 3667-70. PMID: 8631978
Inhibitor of:
αB-crystallin, βA1/3-crystallin, δ-sarcoglycan, γC-crystallin, γE-crystallin, γF-crystallin, 4933437F05Rik, 8-hydroxyguanine, 8-OHdG, 8-oxoG DNA Lesion, AAT-1, AATM, ADH8, Aflatoxin B1, Aflatoxin B2, AIFL, AKR7A2, Alsin, APEH, AROS-29, ATP7B, BACH2, BAT2, Benzo[a]pyrene, BPDE-DNA, BPIL3, C/EBP β, C10orf115, C10orf88, C8A, caspase-9, CAT-4, Cd59b, CDO, CKMT1B, CLEC-18C, Clostridium difficile Toxin A, COASY, COL28A1, COL4A1, COL4A2, CRP, cryptdin 17, cryptdin 21, CSAG3, CSS2, Cypt10, Cystinosin, D430019H16Rik, DEPP, Desmin, Diphtheria Toxin, DPY19L4, E130311K13Rik, E330021D16Rik, EG627821, ENDOG, ENDOGL1, eosinophil peroxidase, ERICH1, EU599041, FAM213A, fibrillin-3, Fibrinogen γ, FOXR1, Fullerene, Gα olf, GADD 153, Glutathione reductase, Gm11570, gp91-phox, GPT2, granzyme D, HADHB, IκB-ε, IL-12B p40, IL-13, IL-1F9, IMP-3, JAM-A, KRTAP2, KRTAP4-4, LITAF, LL-37, LOXHD1, LRP6, LRRC33, MAAI, MAdCAM, Malondialdehyde, MCP-1, MDMA, MMP-13, MPV17L, MPV17L2, Mucin 2L, MYG1, Myofibroblasts, NCB5OR, NGAL, Nitrotyrosine, OBP-2B, Olfr457, Olfr530, Olfr531, Olfr532, Olfr533, Olfr535, Olfr723, Olfr724, Olfr725, Olfr726, Olfr727, Olfr728, Olfr807, Olfr810, Olfr965, Olfr967, Olfr968, Olfr969, Olfr97, OPN, OPN1LW, OPN1SW, ORNT1, Ox-LDL R-1, P-cadherin, P5CR2, p67-phox, PA200, PAOX, PCB, PGAM5, plasminogen, PRX IV, PRX1, RDS, retinitis pigmentosa 1, Romo1, RORβ, Ros, RP1L1, RPGR, Salmonella LPS, SELB, Serine racemase, SLC7A12, SLUG, SMP30, SP-100, Sp5, Sptrx-2, SUSP4, Tim17A, TMEM164, TNF-IP 8L1, Toxoplasma gondii, Tracheobronchial Mucin, TRB-3, TRIM48, TXNDC9, UGRP2, Vanin-1, vanin-2, xCT, and Yersinia pestis F1.Activator of:
α-dystroglycan, α2-Macroglobulin, β-defensin 46, β2-crystallin, β3-crystallin, βA3-crystallin, βA3/A1-crystallin, βB2-crystallin, γ-crystallin, γ-GCSm, γF-crystallin, γN-crystallin, λ-crystallin, 1190007I07Rik, 20S Proteasome α7, 2210016F16Rik, 4930412D23Rik, A20, A230051G13Rik, ABCA4, ABCB5, ABCB7, Abin-2, ADAM22, ADAM23, ADAM25, ADAMTS, ADAMTS-1, ADAMTS-10, ADAMTS-13, ADAMTS-14, ADAMTS-16, ADAMTS-19, ADAMTS-2, ADAMTS-3, ADAMTS-4, ADAMTS-8, ADCK4, Agmatinase, AIF, AIFL, AIPL1, AK4, AKR1C14, AKR7A5, ALAS-E, ALB, ALDH1A7, Aldolase B, ALKBH3, ALR, ALS2CR11, Amd2, Anamorsin, ANKFN1, ANKRD30A, ANKRD46, ANKRD5, ANKZF1, Annexin III, APOBEC1, apoOL, APXL, ArgRS, ASCT2, ASM, ATAD3B, Ataxin-2, Atlastin, Atm, ATP5G3, Atrazine, BAI-2, BC048943, BC100530, BCLAF1, Bex2, Bex3, BF-1, Bfk, BFZB, BOCT, bradykinin B1 R, BRCC3, Brucella abortus LPS, BTBD11, BTBD9, BXDC1, C11orf83, C19orf47, C1orf119, C1orf149, C1orf160, C1orf77, C20orf111, C330006K01Rik, C4BPα, C5orf45, C6orf120, C8orf38, C8orf40, C8orf45, C8orf46, C8orf48, C8orf5, C8orf58, C8orf68, C8orf74, calsyntenin-2, CAT, CAT-4, catalase, CBR4, CD75, Cdc50A, CDNF, CEACAM1 CEACAM2 CEACAM3, CEACAM10, CEACAM11, CEACAM12, CEACAM13, CEACAM14, CEACAM15, CEACAM21, CEACAM4, CEACAM8, CEACAM9, ceruloplasmin, CES8, CFI, CGI-99_2700060E02Rik, CHCHD4, CHCHD6, ChemR23, CHIC2, Ckt2, CLK2, CLN2, CLN3, CLN6, CLPTM1L, COA6, Codanin-1, COMMD5, COMMD8, connexin 33, COQ3, cortexin 3, COX11, COX17, COX3, COX7b2, CPOX, CPXM2, CRMP-2, CRS1C-2, CRS1C-3, CRS4C-2, Cryptosporidium parvum, CRYZL1, CSAD, CSB, CSP, CST, CTH, CYB561D1, CYB5R1, CYB5RL, CYBASC3, CYHR1, Cyp2c69, CYP2J12, CYP2J8, Cypt8, CysRS, cystatin D, cytohesin-2, Cytoplasmic CysRS, D10Jhu81e, Daxx, DCAF15, DDI2, DEC1, DECR1, DFNB59, DGUOK, Dia 2, DIO1, DIRC2, DJ-1, DNA Ligase I, DNAH3, DNAH6, DnaJB2, DnaJC17, DNAJC25-GNG10, DPEP1, DPEP3, Dppa1, DUOX1, Dysbindin 1, dystrophin, E330017A01Rik, EAAT2, EAAT4, Ear10, Ear14, Ear3, Ear4, ECSCR, EF-1 α1, EFP, EG433016, EG434008, EG435601, EG436003, EG619597, EG623186, EG623898, EG626456, EG626575, EG666713, EGFL11, eIF2Bβ, Elastase-1, Elastase-B, EMP-1, EPSTI1, ERIS, ERK 3, Ero1-Lα, Ero1-Lβ, ESD, EST-1, ETHE1, FACE-1, FADD, FAM129B, FAM134A_Fam134a, FAM173A, FAM195B, FANCF, FANCL, FASTKD3, FASTKD5, FATE1, FBXO10, FBXW5, Fc ε RIγ, Ferrochelatase, FGAM Synthase, Fibulin-4, ficolin B, FILIA, Fis1, FLJ39531, FNDC4, FOXRED2, FRP-4, FSTL5, G6PD, GARNL1, GCL, GEFT, Gem, GGCT, GGT6, ghrelin, GITR, Glutathione, Glycophorin C, Glyoxalase II, GlyT1, GNPTG, GPx-1, GPx-3, GPx-4, GPx-6, GPx-7, GPx-8, gremlin-1, Grim19, Grx1, Grx2, GRXCR1, GRXCR2, GSH-1, GSS, GSTK1, GSTT2, GSTT3, Gulo, Gvin1, H2-Dd, HAO1, Haptoglobin, HCCR-1, HEI-C, hemicentin-1, HEXB, HGD, HGSNAT, Hint2, HMBOX1, HMG-I/HMG-Y, Hox11, HPR, HPS-1, HPV16 E6, HRSP12, HSCARG_NMRAL1, HtrA2, Hugl-1, IκB-ζ, IDS, IER3IP1, IFRD2, IFT122, IgG2, IGSF4D, IL-12Rβ1, IL-15Rα, IL-17B, IL-18BP, IL-31, IL-31R, IL-32, IL-5β, IMPDH2, Influenza A m1, ING1, IP6K2, IRAK-2, ISCA1, ISCA1/1L, ISCA2, Isthmin, JIP-1, KAT II, KBTBD10, KCTD11, KDEL ER Marker, KIF3A, Kindlin-1, Klotho, KRTAP13-1, KRTAP16-9, KRTAP19-4, KRTAP4, Krtap4-16, KRTAP4-7, KRTAP9-8, KSP37, Ksr-2, Ku70, LACC1, lactoferrin, Lamin B1, Laminin α-1, Laminin γ-3, LCRG1, Lipoic Acid, LMO4, LMP7, LOC100041273, LOC150383_2210021J22Rik, LOC283398, LOXL2, LOXL4, LPLUNC4, LTB4DH, LTBP-4, LYRM4, M6A, MAN2B1, MAPKAP-1, MAT III, MAWDBP, MCM3, MCP-2, mCST E2, MEF-2B, Mel13, Metallothionein 1G, MetAP-2, METH-1, MGC87042, MGST1, MGST2, Miner2, MIOS, Mitochondrial CysRs, mitochondrial ferritin, Mitofilin, MKP-1, MKP-7, MMP-1a, MOCS3, MOXD1, MP19, MRP-L10, MRP-S34, MRP-S36, MS4A15, MSR, MsrA, MsrB2, MT-MMP-1, MTHFD1L, Mucin 10, Mucin 2L, Mucin 3B, murinoglobulin 2, MUTYH, MXRA5, NAGLU, NALP7, NARFL, NDOR1, NDR2, NDUFB4, Nebulin, NEIL1, NEIL2, neuroglobin, NFU1, NG2, NGF, NMES1, NNT, Nopp140, NOXO1, nuclear protein transcriptional regulator 2, Nucleoredoxin, Nucling, NUDT18, NUDT7, NXNL2, OAT3, Ob-R, OBFC2A, Occludin, Oculomedin, Olfr512, Olfr677, Olfr678, Olfr679, oogenesin 2, oogenesin 3, oogenesin 4, OPA3, OPLAH, OSGIN2, OSMR β, OTTMUSG00000010546, OTTMUSG00000016694, OTUD5, Oxr1, p22-phox, p35, p60 Mitochondrial Marker, PADI2, PADI3, Pael-R, PAM, PANK3, PB1, PCP-4, PDILT, PEDF, PGs2_5730494M16Rik, PICK1, PINX1, PJA2, Plectin, PLEKHA5, PLP, Pma2, PMP22, PMS2, PNP2, PON3, PP2A-B56-β, PQLC1, PRG-3, PRODH, PROSC, PRR17, PRR20A, PRR20C, PRR20D, PRR20E, PRRT2, PRX III, PRX2, PSD3, PSMD1, PTP IA-2β, PTP-MEG2, PTPζ, PUSL1, PXDN, PYROXD2, QAPRTase, QIL1, quiescin Q6, R2, Rad50, Reg II, Renalase, REP-1, Retinoschisin, Rev-erbβ, RFWD3, Rho GDIα, Ribosomal Protein S5, RIP/Rab, RLBP1L2, RNF222, RNF8, RNH1, robo1, ROPN1, RPE65, Rrn3, RTEL1, SBF2, SCRG1, SELENBP1, Selenium, Selenoprotein I, Selenoprotein M, Selenoprotein M marker, Selenoprotein N, Selenoprotein P, Selenoprotein R, Selenoprotein T, Selenoprotein W, SELH, SEPHS2, SerpinA1c, SerpinA1f, SerpinB1, SerpinB6, SESN2, SFXN4, Sir3, Skint8, SKIV2L2, SLAM, SLAMF9, SLC25A29, SNX27, SOCS-4, SOD-1, SOD-3, SP-D, SPATA18, Spatacsin, SPLUNC3, SPTRX-3, Ssa1, Ssa2, SSAT, SSBP1, SSBP4, SSSCA1, STAMP2, STEAP, Sulfiredoxin, SUMO-3, SUSD5, SUV3, SVCT2, Syndecan-3, synphilin-1, Syntaphilin, T-kininogen 1, T-Plastin, TAB182, Taf7l2, Tafazzin, TARSL2, Tau, TAUT, TBR-1, Tenascin-R, Tenascin-X, TERT, Testican-2, TGase5, TIGAR, TIGD3, Tim13B, TMEM135, TMEM162, TMEM71, TMEM98, TMIE, TMUB2, TNFα-IP 8, Tom40, Tom6, TOPORS, TR2IT1, TRAF2, Transketolase, TRAP150, TRF1, Tropomyosin β, TRP14, TrpRS, Trx, Trx-2, TSR3, TSTD1, TTC15, TTC19, TTMP_BC030499, TUSC3, Twist, TXNDC15, TXNDC4, TXNL1, TXNL6, UBE2A, UBE2F, UBE2G2, UBX, UCH-L1, Ufc1, Unc18-1, UQCRH, USP1, USP30, VacA, vanin-1, vanin-3, VAP-1, versican, VEST1, VKORC1L1, VSX1, WDR21C, WDSOF1, WDYHV1, Wolframin, XRCC2, XRCC6BP1, XRRA1, zero, ZFX, ZG16, ZNF425, ZNF439, ZNF683, ZnT-10, and ZnT-6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Acetyl-L-cysteine, 5 g | sc-202232 | 5 g | $33.00 | |||
N-Acetyl-L-cysteine, 25 g | sc-202232A | 25 g | $73.00 | |||
N-Acetyl-L-cysteine, 100 g | sc-202232B | 100 g | $112.00 | |||
N-Acetyl-L-cysteine, 1 kg | sc-202232C | 1 kg | $265.00 |