Molecular structure of Myricetin, CAS Number: 529-44-2
Myricetin (CAS 529-44-2)
See product citations (3)
Alternate Names:
Myricetin is also known as Cannabiscetin.
Application:
Myricetin is a cell-permeable, ATP-competitive inhibitor of various casein kinases and protein kinases.
CAS Number:
529-44-2
Purity:
≥98%
Molecular Weight:
318.24
Molecular Formula:
C15H10O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Myricetin (3,3′,4′,5,5′,7-Hexahydroxyflavone) is a cell-permeable flavanoid used in inflammatory, diabetes, and cancer studies. Myricetin may act to act as a non-ATP competitive inhibitor of MEK-1. Myricetin is also an ATP-competitive inhibitor of several other factors including casein kinases I II, Insulin Receptor, Myosin LC kinase, PKA (Protein Kinases A), PKC (Protein Kinases C), PI 3-kinase and Pim-1 (PIM-1). Myricetin is an inhibitor of CYP2C9, CYP3A4, Maltase-glucoamylase and MYLK. Myricetin demonstrates potent chemopreventative potential by binding JAK1/STAT3 to inhibit the neoplastic transformation of murine JB6 P+ cells and inhibiting MEK1 kinase activity.
Myricetin (CAS 529-44-2) References
- Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. | Walker, EH., et al. 2000. Mol Cell. 6: 909-19. PMID: 11090628
- Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes. | Strobel, P., et al. 2005. Biochem J. 386: 471-8. PMID: 15469417
- Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships. | Ko, WC., et al. 2004. Biochem Pharmacol. 68: 2087-94. PMID: 15476679
- Mechanisms of suppression of nitric oxide production by 3-O-methylquercetin in RAW 264.7 cells. | Jiang, JS., et al. 2006. J Ethnopharmacol. 103: 281-7. PMID: 16213685
- Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. | Lee, KW., et al. 2007. Carcinogenesis. 28: 1918-27. PMID: 17693661
- Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases. | Hagiwara, M., et al. 1988. Biochem Pharmacol. 37: 2987-92. PMID: 3164998
- Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway. | Liao, HH., et al. 2019. Oxid Med Cell Longev. 2019: 6304058. PMID: 31885808
- Myricetin ameliorates ox-LDL-induced HUVECs apoptosis and inflammation via lncRNA GAS5 upregulating the expression of miR-29a-3p. | Bai, Y., et al. 2021. Sci Rep. 11: 19637. PMID: 34608195
- Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature. | Crocetto, F., et al. 2021. Nutrients. 13: PMID: 34836005
- Myricetin Restores Aβ-Induced Mitochondrial Impairments in N2a-SW Cells. | Yao, X., et al. 2022. ACS Chem Neurosci. 13: 454-463. PMID: 35114083
- Myricetin inhibits interferon-γ-induced PD-L1 and IDO1 expression in lung cancer cells. | Chen, YC., et al. 2022. Biochem Pharmacol. 197: 114940. PMID: 35120895
- Hypoglycemic activity and mechanisms of myricetin. | Qian, J., et al. 2022. Nat Prod Res. 36: 6177-6180. PMID: 35369824
- Myricetin Inhibits α-Synuclein Amyloid Aggregation by Delaying the Liquid-to-Solid Phase Transition. | Xu, B., et al. 2022. Chembiochem. 23: e202200216. PMID: 35657723
- Myricetin Improves Impaired Nerve Functions in Experimental Diabetic Rats. | Ma, J., et al. 2022. Front Endocrinol (Lausanne). 13: 915603. PMID: 35928887
Inhibitor of:
α-Amylase, from pig pancreas, β-defensin 129, μ-crystallin, 15-LO, ADCK4, Apg-2 (HSPA4), C15orf41, CaMK2N2, CaMKV, Casein Kinase, CCDC141, CHMP7, Coronavirus nucleocapsid, creatine kinase-M, CRISP-1, CYP2C9, CYP3A4, DDX34, DDX50, DDX57, DHX33, DnaJB3, EphB5, Factor H, FAM22A, FN3K, GAL3ST3, Galactose Mutarotase, galectin-3, Glucose-6-Phosphate Dehydrogenase, Glut11, HSC 70, HSF3, HSP 105, HspBP1, HSV-1 gG, KRTAP13, MAdCAM, Maltase-glucoamylase, MEK-1, MOV10, MYLK, Naglt1c, NKHC1, nPKC ε, OGG1, PC1, PEBP-4, PGP-I, PI 3-kinase, Pim-1, PKA, PKC, prefoldin 2, Rabies Virus, RAO, RFT1, RSP3, Ser/Thr Protein Kinase, SGLT-3, SI-CLP, SLC43A1, Slfn1, SULT2A5, SV40 T Ag, Syntaxin 11, Syntaxin 5, TCP-1 ζ, UBA52, UGT1A6B, UGT2A1, UGT2B37, UGT2B5, V1RC20, V1RC23, V1RC28, vanin-3, and ZNF737.Activator of:
AGE-1, apoE, BBS9, Bclp2, C11orf59, Dmrtc1b, DNA pol ε, DNA pol ε 4, DNA pol ε ss, DNAH2, DNAH7, DnaJB3, DUX1, GPN2, HEB, IRS-1, KIF12, La Crosse Virus G1, LOC646567, LTBP-3, METT10D, Mrf-2, neuroguidin, OR2T29, RAG1AP1, Siglec-G, SIRT1, SPAG1, SR-4, SRPK1, SULT2A1, TCR C β, TSPY, UNC-5, and Vitronectin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Myricetin, 25 mg | sc-203147 | 25 mg | $95.00 | |||
Myricetin, 100 mg | sc-203147A | 100 mg | $184.00 | |||
Myricetin, 1 g | sc-203147B | 1 g | $255.00 | |||
Myricetin, 25 g | sc-203147C | 25 g | $500.00 | |||
Myricetin, 100 g | sc-203147D | 100 g | $1002.00 |