Muscimol A potent and specific GABAA receptor agonist/GABA analog

Muscimol (CAS 2763-96-4)

Muscimol | CAS 2763-96-4 is rated 5.0 out of 5 by 1.
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Synonym: 3-Hydroxy-5-aminomethyl-isoxazole;5-Aminomethyl-3-isoxazolol;5-Aminomethyl-3-hydroxy-isoxazole
Application: A potent and specific GABAA receptor agonist/GABA analog
CAS Number: 2763-96-4
Purity: ≥98%
Molecular Weight: 114.10
Molecular Formula: C4H6N2O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Muscimol is a naturally occurring alkaloid isolated from various Amanita mushrooms, functional as a potent and selective agonist of the GABAA receptor. The structure of Muscimol places the binding functionalities (amine, hydroxyl) in a spatial arrangement almost identical to that of GABA, allowing recognition of Muscimol at the highly specific GABAA binding site. Muscimol has been widely employed for this agonist activity in studies probing the consequent effects of GABAA stimulation.


References

1. Chilton, W.S. and Ott, J. 1976. Lloydia. 39: 150-157. PMID: 985999
2. Woodward, R.M., et al. 1993. Mol. Pharmacol. 43: 609-625. PMID: 8386310
3. Frølund, B., et al. 2002. Curr Top Med Chem. 2: 817-832. PMID: 12171573
4. Michelot, D., et al. 2003. Mycol. Res. 107: 131-146. PMID: 12747324

Usage :
Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Physical State :
Solid
Solubility :
Soluble in water (10 mg/ml), methanol, ethanol, 0.05 M HCl (20 mg/ml), DMSO (sparingly soluble), DMF (sparingly soluble), and PBS (pH 7.2) (10 mg/ml).
Storage :
Store at 4° C
Melting Point :
105.68° C (Predicted)
Boiling Point :
~325° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
IC50 :
GABA-A receptor; anion channel: IC50 = 3.2 nM (rat); GABA receptor alpha-1 subunit: IC50 = 2 nM (human); Adenosine A3 receptor: IC50 = 16 nM (human)
Ki Data :
GABA-A receptor; anion channel: Ki= 4 nM (rat); GABA receptor gamma-2 subunit: Ki= 11 nM (human); GABA receptor delta subunit: Ki= 11 nM (human)
pK Values :
pKa: 7.42 (Predicted), pKb: 8.31 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NY3325000
Transport :
UN 1544, Class 6.1, Packing group II
PubChem CID :
4266
Merck Index :
14: 6312
MDL Number :
MFCD00057894
EC Number :
220-430-4
Beilstein Registry :
1618960
SMILES :
C1=C(ONC1=O)CN

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Muscimol  Product Citations

See how others have used Muscimol. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26912647  Emmanouilidou, E. et al. 2016. Brain : a journal of neurology. 139: 871-90.

PMID: # 25697356  Zhao, G. et al. 2015. The Journal of biological chemistry. 290: 8949-63.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Oliveira Oliveira-Pinto, J. et al. (PubMed 26056730) used the GABAA receptor agonist Muscimol to cause an overactivation. This GABAA overactivation potentiated the effects of NMDA blockade during the brain growth spurt in eliciting locomotor hyperactivity in juvenile mice. -SCBT Publication Review
Date published: 2015-06-27
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