Muscimol is a naturally occurring alkaloid isolated from various Amanita mushrooms, functional as a potent and selective agonist of the GABAA receptor. The structure of Muscimol places the binding functionalities (amine, hydroxyl) in a spatial arrangement almost identical to that of GABA, allowing recognition of Muscimol at the highly specific GABAA binding site. Muscimol has been widely employed for this agonist activity in studies probing the consequent effects of GABAA stimulation.
1. Chilton, W.S. and Ott, J. 1976. Lloydia. 39: 150-157. PMID: 985999 2. Woodward, R.M., et al. 1993. Mol. Pharmacol. 43: 609-625. PMID: 8386310 3. Frølund, B., et al. 2002. Curr Top Med Chem. 2: 817-832. PMID: 12171573 4. Michelot, D., et al. 2003. Mycol. Res. 107: 131-146. PMID: 12747324
Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Soluble in water (10 mg/ml), methanol, ethanol, 0.05 M HCl (20 mg/ml), DMSO (sparingly soluble), DMF (sparingly soluble), and PBS (pH 7.2) (10 mg/ml).
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OliveiraOliveira-Pinto, J. et al. (PubMed 26056730) used the GABAA receptor agonist Muscimol to cause an overactivation. This GABAA overactivation potentiated the effects of NMDA blockade during the brain growth spurt in eliciting locomotor hyperactivity in juvenile mice. -SCBT Publication Review
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