Date published: 2025-10-3

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Methyl 6-Oxohexanoate (CAS 6654-36-0)

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Alternate Names:
Methyl 5-formylvalerate; Adipic Semialdehyde Methyl Ester; 5-Carbomethoxy-1-pentanal
CAS Number:
6654-36-0
Purity:
≥95%
Molecular Weight:
144.17
Molecular Formula:
C7H12O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Methyl 6-oxohexanoate, a naturally occurring compound with a molecular weight of 144.7 g/mol, possesses six carbon atoms. It exists as a colorless liquid with a subtle scent and a boiling point between 120-122° C. Extensive research has explored the potential applications of Methyl 6-oxohexanoate in biotechnology. It finds utility as a substrate in the manufacturing of industrial enzymes and as a foundational material for synthesis. Methyl 6-oxohexanoate functions as an inhibitor for the enzyme cyclooxygenase-2 (COX-2), a key player in the production of inflammatory compounds. This compound effectively binds to the enzyme′s active site, thwarting its activity and preventing the generation of inflammatory substances.


Methyl 6-Oxohexanoate (CAS 6654-36-0) References

  1. Synthesis of a ketone analogue of biotin via the intramolecular Pauson-Khand reaction.  |  McNeill, E., et al. 2006. Org Lett. 8: 4593-5. PMID: 16986958
  2. Synthesis, molecular docking and biological evaluation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition.  |  Pirali, T., et al. 2010. Mol Divers. 14: 109-21. PMID: 19475493
  3. One-pot AgOAc-mediated synthesis of polysubstituted pyrroles from primary amines and aldehydes: application to the total synthesis of purpurone.  |  Li, Q., et al. 2010. Org Lett. 12: 4066-9. PMID: 20734981
  4. Oxidation of organotrifluoroborates via oxone.  |  Molander, GA. and Cavalcanti, LN. 2011. J Org Chem. 76: 623-30. PMID: 21192650
  5. Reactions of difunctional electrophiles with functionalized aryllithium compounds: remarkable chemoselectivity by flash chemistry.  |  Nagaki, A., et al. 2015. Angew Chem Int Ed Engl. 54: 1914-8. PMID: 25504778
  6. Synthesis and Biopharmaceutical Evaluation of Imatinib Analogues Featuring Unusual Structural Motifs.  |  Nicolaou, KC., et al. 2016. ChemMedChem. 11: 31-7. PMID: 26585829
  7. Organocatalytic Approach for Short Asymmetric Synthesis of (R)-Paraconyl Alcohol: Application to the Total Syntheses of IM-2, SCB2, and A-Factor γ-Butyrolactone Autoregulators.  |  Sarkale, AM., et al. 2018. J Org Chem. 83: 4167-4172. PMID: 29490143
  8. Family of Structurally Related Bioconjugates Yields Antibodies with Differential Selectivity against Ketamine and 6-Hydroxynorketamine.  |  Zheng, Z., et al. 2021. ACS Chem Neurosci. 12: 4113-4122. PMID: 34652905
  9. A complementary chemical probe approach towards customized studies of G-quadruplex DNA structures in live cells.  |  Prasad, B., et al. 2022. Chem Sci. 13: 2347-2354. PMID: 35310480
  10. Biotransformation of linoleic acid with the Candida tropicalis M25 mutant.  |  Fabritius, D., et al. 1997. Appl Microbiol Biotechnol. 48: 83-7. PMID: 9274051
  11. Antipsoriatic anthrones with modulated redox properties. 4. Synthesis and biological activity of novel 9,10-dihydro-1,8-dihydroxy-9-oxo-2-anthracenecarboxylic and -hydroxamic acids.  |  Müller, K. and Prinz, H. 1997. J Med Chem. 40: 2780-7. PMID: 9276024

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Methyl 6-Oxohexanoate, 1 g

sc-211873
1 g
$393.00