Matrine (CAS 519-02-8)
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Matrine is an alkaloid found in plants of the Sophora familiy. It has various effects including antineoplastic, antifibrotic, anti-inflammatory, and antitumor activities. It depresses both glutamate-induced responses and neurally evoked excitatory junctional potentials. Additionally, it induces apoptosis by collapsing mitochondrial membrane potential. This compound is also a selective KOR (kappa-opioid receptor) agonist. It inhibits LPS-induced splenocyte proliferation and release of IL-1 and IL-6 from mouse peritoneal macrophages in vitro. Matrine reduces production of the hepatitis B surface antigen (HBsAG) and serum antigen (HBeAG) with IC50 values of 0.75 and 3.35 mg/mL, respectively, in vitro. Also in vitro, Matrine inhibits angiotension II-induced hyperplastic growth of cardiac fibroblasts in a dose-dependent manner. Furthermore, Matrine inhibits proliferation of melanoma, breast, and colon cancer cells with IC50s ranging from 0.769-2.758 mg/ml.
Matrine (CAS 519-02-8) References
- Matrine: Bioactivities and Structural Modifications. | Huang, J. and Xu, H. 2016. Curr Top Med Chem. 16: 3365-3378. PMID: 27150374
- Matrine Attenuates D-Galactose-Induced Aging-Related Behavior in Mice via Inhibition of Cellular Senescence and Oxidative Stress. | Sun, K., et al. 2018. Oxid Med Cell Longev. 2018: 7108604. PMID: 30598725
- Matrine-Family Alkaloids: Versatile Precursors for Bioactive Modifications. | Cai, XH., et al. 2020. Med Chem. 16: 431-453. PMID: 31378199
- Matrine attenuates pathological cardiac fibrosis via RPS5/p38 in mice. | Zhang, X., et al. 2021. Acta Pharmacol Sin. 42: 573-584. PMID: 32694761
- Matrine exhibits antiviral activity in a PRRSV/PCV2 co-infected mouse model. | Sun, N., et al. 2020. Phytomedicine. 77: 153289. PMID: 32771536
- Matrine attenuates cardiomyocyte ischemia-reperfusion injury through activating AMPK/Sirt3 signaling pathway. | Lu, Q., et al. 2021. J Recept Signal Transduct Res. 41: 488-493. PMID: 33019890
- Biological effects and mechanisms of matrine and other constituents of Sophora flavescens in colorectal cancer. | Chen, MH., et al. 2021. Pharmacol Res. 171: 105778. PMID: 34298110
- Src acts as the target of matrine to inhibit the proliferation of cancer cells by regulating phosphorylation signaling pathways. | Zhang, X., et al. 2021. Cell Death Dis. 12: 931. PMID: 34642304
- Matrine exerted an anti-tumor effect on acute myeloid leukemia via the lncRNA LINC01116/miR-592-mediated JAK/STAT pathway inactivation. | Zhang, PP., et al. 2022. Neoplasma. 69: 123-135. PMID: 34881627
- Research progress of matrine's anticancer activity and its molecular mechanism. | Chen, F., et al. 2022. J Ethnopharmacol. 286: 114914. PMID: 34919987
- Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review. | Lin, Y., et al. 2022. Drug Des Devel Ther. 16: 533-569. PMID: 35256842
- Matrine impedes colorectal cancer proliferation and migration by downregulating endoplasmic reticulum lipid raft associated protein 1 expression. | Ren, H., et al. 2022. Bioengineered. 13: 9780-9791. PMID: 35412433
- Matrine inhibits the Wnt3a/β-catenin/TCF7L2 signaling pathway in experimental autoimmune encephalomyelitis. | Ma, R., et al. 2022. J Neuroimmunol. 367: 577876. PMID: 35489221
- Matrine induces autophagy in human neuroblastoma cells via blocking the AKT-mTOR pathway. | Liu, N., et al. 2022. Med Oncol. 39: 167. PMID: 35972593
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Matrine, 100 mg | sc-205741 | 100 mg | $242.00 | |||
Matrine, 500 mg | sc-205741A | 500 mg | $544.00 |