Date published: 2025-11-3

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Matairesinol (CAS 580-72-3)

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Alternate Names:
(−)-Matairesinol
Application:
Matairesinol is a principle plant lignan consituent of dietary fiber
CAS Number:
580-72-3
Purity:
≥95%
Molecular Weight:
358.39
Molecular Formula:
C20H22O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Matairesinol, one of the principle lignands present in dietary fiber, undergoes metabolism by enteric bacteria to yield enterolactone and enterodiol. The inverse association observed between serum enterolactone levels and serum isoprostane levels suggests a potential protective effect against oxidative injury. Furthermore, Matairesinol acts as an inhibitor of Mdr-1. This naturally occurring phytochemical is abundantly present in the bark and needles of various coniferous trees. Classified as a lignan, which falls under the category of polyphenols. Although the exact mechanism of action remains partially elusive, Matairesinol is believed to function as an antioxidant, effectively scavenging free radicals and mitigating oxidative stress. It is also considered to possess anti-inflammatory properties, which contribute to the reduction of inflammation and promotion of healing processes. Additionally, Matairesinol is recognized for its potential as a neuroprotective agent, shielding neurons from damage and fostering optimal neurological function. The diverse range of biochemical and physiological effects attributed to Matairesinol encompasses the reduction of oxidative stress, mitigation of inflammation, and safeguarding neurons against harm.


Matairesinol (CAS 580-72-3) References

  1. Studies on the metabolism of the plant lignans secoisolariciresinol and matairesinol.  |  Niemeyer, HB., et al. 2003. J Agric Food Chem. 51: 6317-25. PMID: 14518962
  2. Radical and superoxide scavenging activities of matairesinol and oxidized matairesinol.  |  Yamauchi, S., et al. 2006. Biosci Biotechnol Biochem. 70: 1934-40. PMID: 16926506
  3. Secoisolariciresinol and matairesinol of sea buckthorn (Hippophaë rhamnoides L.) berries of different subspecies and harvesting times.  |  Yang, B., et al. 2006. J Agric Food Chem. 54: 8065-70. PMID: 17032010
  4. Immunomodulatory effect of (--)-matairesinol in vivo and ex vivo.  |  Yamawaki, M., et al. 2011. Biosci Biotechnol Biochem. 75: 859-63. PMID: 21597179
  5. Matairesinol inhibits angiogenesis via suppression of mitochondrial reactive oxygen species.  |  Lee, B., et al. 2012. Biochem Biophys Res Commun. 421: 76-80. PMID: 22483751
  6. Cytotoxicity of arctigenin and matairesinol against the T-cell lymphoma cell line CCRF-CEM.  |  Su, S., et al. 2015. J Pharm Pharmacol. 67: 1316-23. PMID: 25922263
  7. Forsythia suspensa fruit extracts and the constituent matairesinol confer anti-allergic effects in an allergic dermatitis mouse model.  |  Sung, YY., et al. 2016. J Ethnopharmacol. 187: 49-56. PMID: 27085937
  8. Matairesinol Suppresses Neuroinflammation and Migration Associated with Src and ERK1/2-NF-κB Pathway in Activating BV2 Microglia.  |  Xu, P., et al. 2017. Neurochem Res. 42: 2850-2860. PMID: 28512713
  9. Matairesinol ameliorates experimental autoimmune uveitis by suppression of IRBP-specific Th17 cells.  |  Li, X., et al. 2020. J Neuroimmunol. 345: 577286. PMID: 32559555
  10. Matairesinol, an active constituent of HC9 polyherbal formulation, exhibits HDAC8 inhibitory and anticancer activity.  |  Mahajan, M., et al. 2021. Biophys Chem. 273: 106588. PMID: 33848944
  11. Effects of in vitro exposure of sheep ovarian tissue to zearalenone and matairesinol on preantral follicles.  |  Brito, DCC., et al. 2022. Zygote. 30: 419-422. PMID: 34689852
  12. Matairesinol exerts anti-inflammatory and antioxidant effects in sepsis-mediated brain injury by repressing the MAPK and NF-κB pathways through up-regulating AMPK.  |  Wu, Q., et al. 2021. Aging (Albany NY). 13: 23780-23795. PMID: 34705665
  13. Matairesinol Induces Mitochondrial Dysfunction and Exerts Synergistic Anticancer Effects with 5-Fluorouracil in Pancreatic Cancer Cells.  |  Lee, W., et al. 2022. Mar Drugs. 20: PMID: 35892941
  14. Matairesinol Nanoparticles Restore Chemosensitivity and Suppress Colorectal Cancer Progression in Preclinical Models: Role of Lipid Metabolism Reprogramming.  |  Wu, S., et al. 2023. Nano Lett. 23: 1970-1980. PMID: 36802650

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Matairesinol, 1 mg

sc-205379
1 mg
$56.00

Matairesinol, 5 mg

sc-205379A
5 mg
$170.00

Matairesinol, 25 mg

sc-205379B
25 mg
$795.00