Date published: 2025-10-14

1-800-457-3801

SCBT Portrait Logo
Seach Input

Luteolin (CAS 491-70-3)

5.0(1)
Write a reviewAsk a question

See product citations (40)

Alternate Names:
Luteolin is also known as 3′,4′,5,7-Tetrahydroxyflavone.
Application:
Luteolin is an inhibitor of LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocker of NF-κB and AP-1 activation.
CAS Number:
491-70-3
Purity:
≥98%
Molecular Weight:
286.24
Molecular Formula:
C15H10O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Luteolin is an antioxidant flavonoid and a free radical scavenger. It inhibits rat liver cytosolic glutathione S-transferase activity and soybean and reticulocyte 15-LO (15-lipoxygenases). Luteolin also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with Luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle.


Luteolin (CAS 491-70-3) References

  1. Inhibition of matrix-proteases by polyphenols: chemical insights for anti-inflammatory and anti-invasion drug design.  |  Sartor, L., et al. 2002. Biochem Pharmacol. 64: 229-37. PMID: 12123743
  2. Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens.  |  Ueda, H., et al. 2002. Biol Pharm Bull. 25: 1197-202. PMID: 12230117
  3. Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action.  |  Sadik, CD., et al. 2003. Biochem Pharmacol. 65: 773-81. PMID: 12628491
  4. Luteolin prevents irinotecan-induced intestinal mucositis in mice through antioxidant and anti-inflammatory properties.  |  Boeing, T., et al. 2020. Br J Pharmacol. 177: 2393-2408. PMID: 31976547
  5. Luteolin alleviates cognitive impairment in Alzheimer's disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation.  |  Kou, JJ., et al. 2022. Acta Pharmacol Sin. 43: 840-849. PMID: 34267346
  6. Luteolin Inhibits Breast Cancer Stemness and Enhances Chemosensitivity through the Nrf2-Mediated Pathway.  |  Tsai, KJ., et al. 2021. Molecules. 26: PMID: 34770867
  7. Exploration of the mechanism of luteolin against ischemic stroke based on network pharmacology, molecular docking and experimental verification.  |  Dong, R., et al. 2021. Bioengineered. 12: 12274-12293. PMID: 34898370
  8. Luteolin relieves lung cancer-induced bone pain by inhibiting NLRP3 inflammasomes and glial activation in the spinal dorsal horn in mice.  |  Zhou, YS., et al. 2022. Phytomedicine. 96: 153910. PMID: 35026502
  9. Radioprotective effect of antioxidative flavonoids in gamma-ray irradiated mice.  |  Shimoi, K., et al. 1994. Carcinogenesis. 15: 2669-72. PMID: 7955124
  10. Effects of gamma-linolenic acid, flavonoids, and vitamins on cytotoxicity and lipid peroxidation.  |  Ramanathan, R., et al. 1994. Free Radic Biol Med. 16: 43-8. PMID: 8299995
  11. Flavonoids activate wild-type p53.  |  Plaumann, B., et al. 1996. Oncogene. 13: 1605-14. PMID: 8895505
  12. Antioxidant and chelating properties of flavonoids.  |  Korkina, LG. and Afanas'ev, IB. 1997. Adv Pharmacol. 38: 151-63. PMID: 8895808

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Luteolin, 5 mg

sc-203119
5 mg
$26.00

Luteolin, 50 mg

sc-203119A
50 mg
$50.00

Luteolin, 500 mg

sc-203119B
500 mg
$99.00

Luteolin, 5 g

sc-203119C
5 g
$150.00

Luteolin, 500 g

sc-203119D
500 g
$1887.00

What is the solubility of Luteolin in DMSO?

Asked by: Catarina
Thank you for your question. Luteolin is soluble in aqueous alkaline solutions (1.4 mg/ml), ethanol (~5 mg/ml), DMSO, 1eq. NaOH (5 mM), DMF (~20 mg/ml), 1:5 solution of DMF:PBS(pH7.2) (`~1 mg/ml), water (1 mg/ml at 25° C), and methanol.
Answered by: Tech Support Europe
Date published: 2024-06-17
  • y_2025, m_10, d_9, h_7CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_203119, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 101ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Shimoi et alShimoi et al. (PubMed ID 7955124) found that luteolin reduced MNRET frequencies and inhibited lipid peroxidation in mice. -SCBT Publication Review
Date published: 2015-02-16
  • y_2025, m_10, d_9, h_7
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203119, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 15ms
  • REVIEWS, PRODUCT
Luteolin is rated 5.0 out of 5 by 1.
  • y_2025, m_10, d_9, h_7
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203119, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 103ms
  • REVIEWS, PRODUCT