Molecular structure of LTC4 (Leukotriene C4), CAS Number: 72025-60-6
LTC4 (Leukotriene C4) (CAS 72025-60-6)
Alternate Names:
5S-Hydroxy-6R-(S-glutathionyl)-7E,9E,11Z,14Z-eicosatetraenoic acid
Application:
LTC4 (Leukotriene C4) is a potent agonist for contraction of smooth muscle, wtih many important immunomodulatory functions
CAS Number:
72025-60-6
Molecular Weight:
625.77
Molecular Formula:
C30H47N3O9S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
LTC4 (Leukotriene C4), and other leukotrienes, are potent eicosanoid lipid mediators that play numerous roles in inflammation, immunological functions and maintaining biological homeostasis primarily acting through specific G protein-coupled receptors. This product is a potent arachidonic acid (sc-200770)-derived agonist for contraction of smooth muscle and may act to induce microvascular permeability and mucus secretion in airways. Furthermore, this product may act to enhance growth of human airway epithelial cells, reduce myocardial contractility and coronary blood flow, induce long lasting hypotension, and stimulate angiogenesis. LTC4 (Leukotriene C4) is an inhibitor of MGST.
LTC4 (Leukotriene C4) (CAS 72025-60-6) References
- Prostaglandins and leukotrienes: advances in eicosanoid biology. | Funk, CD. 2001. Science. 294: 1871-5. PMID: 11729303
- Transport of leukotriene C4 and structurally related conjugates. | Jedlitschky, G. and Keppler, D. 2002. Vitam Horm. 64: 153-84. PMID: 11898391
- Cysteinyl leukotrienes enhance growth of human airway epithelial cells. | Leikauf, GD., et al. 1990. Am J Physiol. 259: L255-61. PMID: 2171354
- Leukotriene C4 aggravates bleomycin-induced pulmonary fibrosis in mice. | Hirata, H., et al. 2013. Respirology. 18: 674-81. PMID: 23432979
- Leukotriene C4 stimulates angiogenesis in bovine carotid artery endothelial cells in vitro. | Kanayasu, T., et al. 1989. Biochem Biophys Res Commun. 159: 572-8. PMID: 2467671
- Leukotriene C4 increases the susceptibility of adult mice to Shiga toxin-producing Escherichia coli infection. | Cabrera, G., et al. 2015. Int J Med Microbiol. 305: 910-7. PMID: 26456732
- Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage. | Dvash, E., et al. 2015. Nat Commun. 6: 10112. PMID: 26656251
- Leukotriene C4 as a mediator of luteinizing hormone release from rat anterior pituitary cells. | Hulting, AL., et al. 1985. Proc Natl Acad Sci U S A. 82: 3834-8. PMID: 2987949
- Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response. | Dahlén, SE., et al. 1981. Proc Natl Acad Sci U S A. 78: 3887-91. PMID: 6267608
- Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4. | Dahlén, SE., et al. 1983. Proc Natl Acad Sci U S A. 80: 1712-6. PMID: 6300870
- The actions of leukotrienes C4 and D4 on guinea-pig isolated hearts. | Letts, LG. and Piper, PJ. 1982. Br J Pharmacol. 76: 169-76. PMID: 6896291
- Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro. | Marom, Z., et al. 1982. Am Rev Respir Dis. 126: 449-51. PMID: 7125334
- Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers. | Bannenberg, G., et al. 1999. J Biol Chem. 274: 1994-9. PMID: 9890956
Inhibitor of:
MGST.Activator of:
EDG-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LTC4 (Leukotriene C4), 50 µg | sc-201046 | 50 µg | $300.00 | |||
LTC4 (Leukotriene C4), 300 µg | sc-201046A | 300 µg | $2850.00 |