LTC4 (Leukotriene C4)

LTC4 (Leukotriene C4)  (CAS 72025-60-6)

LTC4 (Leukotriene C4), CAS 72025-60-6 is rated 5.0 out of 5 by 1.
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Synonym: 5S-Hydroxy-6R-(S-glutathionyl)-7E,9E,11Z,14Z-eicosatetraenoic acid
Application: A potent agonist for contraction of smooth muscle, wtih many important immunomodulatory functions
CAS Number: 72025-60-6
Molecular Weight: 625.77
Molecular Formula: C30H47N3O9S
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
LTC4 (Leukotriene C4) sc-201046 50 µg $249.00
LTC4 (Leukotriene C4) sc-201046A 300 µg $2,850.00

LTC4 (Leukotriene C4), and other leukotrienes, are potent eicosanoid lipid mediators that play numerous roles in inflammation, immunological functions and maintaining biological homeostasis; primarily acting through specific G protein-coupled receptors. This product is a potent arachidonic acid (sc-200770)-derived agonist for contraction of smooth muscle and has been shown to induce microvascular permeability and mucus secretion in airways. Furthermore, this product has been shown to enhance growth of human airway epithelial cells, reduce myocardial contractility and coronary blood flow, induce long lasting hypotension, and stimulate angiogenesis. LTC4 (Leukotriene C4) is an inhibitor of MGST.


References

1. Leikauf, G D., et al., 1990. Cysteinyl leukotrienes enhance growth of human airway epithelial cells. The American journal of physiology. 259(4 Pt 1): L255-61. PMID: 2171354
2. Kanayasu, T., et al., 1989. Leukotriene C4 stimulates angiogenesis in bovine carotid artery endothelial cells in vitro. Biochemical and biophysical research communications. 159(2): 572-8. PMID: 2467671
3. Hulting, A L., et al., 1985. Leukotriene C4 as a mediator of luteinizing hormone release from rat anterior pituitary cells. Proceedings of the National Academy of Sciences of the United States of America. 82(11): 3834-8. PMID: 2987949
4. Dahlén, S E., et al., 1981. Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response. Proceedings of the National Academy of Sciences of the United States of America. 78(6): 3887-91. PMID: 6267608
5. Dahlén, S E., et al., 1983. Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4. Proceedings of the National Academy of Sciences of the United States of America. 80(6): 1712-6. PMID: 6300870
6. Letts, L G., et al., 1982. The actions of leukotrienes C4 and D4 on guinea-pig isolated hearts. British journal of pharmacology. 76(1): 169-76. PMID: 6896291
7. Marom, Z., et al., 1982. Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro. The American review of respiratory disease. 126(3): 449-51. PMID: 7125334
8. Funk, C D., et al., 2001. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science (New York, N.Y.). 294(5548): 1871-5. PMID: 11729303

Formulation :
50 µg/ml in methanol/ammonium acetate buffer, 65:35, pH 5.6
Physical State :
Liquid
Solubility :
Soluble in water (100 µg/ml) at 25° C.
pH :
5.6
Storage :
Store at -80° C
Melting Point :
-114.4° C
Boiling Point :
78.5° C
Refractive Index :
n20D 1.56
IC50 :
ABCC2 overexpressed: IC50 = 0.15 µM (MDCK cell)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
MB9143500
Transport :
UN 1230, Class 3(6.1), Packing group II
PubChem CID :
5280493
Merck Index :
14: 5455
MDL Number :
MFCD00151079
SMILES :
CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Marom et al Marom et al. (PubMed ID 7125334) showed that an increase in LTC4 (Leukotriene C4) led to an elevation in mucous production in human airways in vitro. -SCBT Publication Review
Date published: 2015-05-28
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