Licochalcone-A, Synthetic: sc-319884. Western blot analysis of Cdc2 p34 expression in untreated (A) and Licochalcone-A, Synthetic treated (B) PC-3 whole cell lysates. Note down regulation of Cdc2 p34 expression in lane B. Antibody tested: Cdc2 p34 (PSTAIRE): sc-53.
Licochalcone A (CAS 58749-22-7)
See product citations (2)
Alternate Names:
E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one
Application:
Licochalcone A is a flavonoid capable of inhibiting Bcl-2 expression and inducing apoptosis
CAS Number:
58749-22-7
Purity:
≥96%
Molecular Weight:
338.40
Molecular Formula:
C21H22O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Licochalcone A, also referred to as licorice root extract, originates from the root of Glycyrrhiza uralensis. Furthermore, in vitro studies utilizing cell cultures have focused on evaluating its efficacy in inhibiting cancer cell growth and inducing apoptosis, a programmed cell death. Although the precise mechanism of action of licochalcone A remains elusive, it is believed to operate through multiple pathways. Notably, it suppresses cell proliferation and triggers apoptosis. Additionally, this compound has been found to impede the activity of transcription factors, proteins responsible for regulating gene expression.
Licochalcone A (CAS 58749-22-7) References
- The antileishmanial activity of novel oxygenated chalcones and their mechanism of action. | Zhai, L., et al. 1999. J Antimicrob Chemother. 43: 793-803. PMID: 10404318
- Modulation of bcl-2 and cytotoxicity by licochalcone-A, a novel estrogenic flavonoid. | Rafi, MM., et al. 2000. Anticancer Res. 20: 2653-8. PMID: 10953339
- Antibacterial activity of licochalcone A against spore-forming bacteria. | Tsukiyama, R., et al. 2002. Antimicrob Agents Chemother. 46: 1226-30. PMID: 11959549
- Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells. | Fu, Y., et al. 2004. Biochem Biophys Res Commun. 322: 263-70. PMID: 15313200
- Anti-inflammatory activity of licochalcone A isolated from Glycyrrhiza inflata. | Cui, Y., et al. 2008. Z Naturforsch C J Biosci. 63: 361-5. PMID: 18669021
- Anti-proliferative effect of licochalcone A on vascular smooth muscle cells. | Park, JH., et al. 2008. Biol Pharm Bull. 31: 1996-2000. PMID: 18981562
- Influence of subinhibitory concentrations of licochalcone A on the secretion of enterotoxins A and B by Staphylococcus aureus. | Qiu, J., et al. 2010. FEMS Microbiol Lett. 307: 135-41. PMID: 20412304
- Protective Effects of Licochalcone A Ameliorates Obesity and Non-Alcoholic Fatty Liver Disease Via Promotion of the Sirt-1/AMPK Pathway in Mice Fed a High-Fat Diet. | Liou, CJ., et al. 2019. Cells. 8: PMID: 31083505
- Licochalcone A Promotes the Ubiquitination of c-Met to Abrogate Gefitinib Resistance. | Han, S., et al. 2022. Biomed Res Int. 2022: 5687832. PMID: 35309168
- Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection. | Chen, M., et al. 1994. Antimicrob Agents Chemother. 38: 1470-5. PMID: 7979274
- Mechanisms of tolerance to sodium nitroprusside in rat cultured aortic smooth muscle cells. | Papapetropoulos, A., et al. 1996. Br J Pharmacol. 117: 147-55. PMID: 8825356
- Mode of antibacterial action of retrochalcones from Glycyrrhiza inflata. | Haraguchi, H., et al. 1998. Phytochemistry. 48: 125-9. PMID: 9621457
- Licochalcone A: an inducer of cell differentiation and cytotoxic agent from Pogostemon cablin. | Park, EJ., et al. 1998. Planta Med. 64: 464-6. PMID: 9690352
Inhibitor of:
Bcl-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Licochalcone A, 5 mg | sc-319884 | 5 mg | $73.00 |