Molecular structure of Lanosterol, CAS Number: 79-63-0
Lanosterol (CAS 79-63-0)
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Alternate Names:
3β-Hydroxy-8,24-lanostadiene; 8,24-Lanostadien-3β-ol
Application:
Lanosterol is a precursor of cholesterol
CAS Number:
79-63-0
Purity:
≥95%
Molecular Weight:
426.72
Molecular Formula:
C30H50O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Lanosterol is also a key component of the plasma membrane of eukaryotic cells, and is involved in the regulation of cellular permeability and membrane fluidity. Lanosterol interacts with the transcription factor NF-κB, which plays a part in managing various cell functions, including those involved in inflammation and cell death. It also affects enzymes linked to the cholesterol production pathway and may act to inhibit the enzyme HMG-CoA reductase, a key player in cholesterol synthesis.
Lanosterol (CAS 79-63-0) References
- Membrane-bound enzymes of cholesterol synthesis from lanosterol. | Gaylor, JL. 2002. Biochem Biophys Res Commun. 292: 1139-46. PMID: 11969204
- Lanosterol and tetranorlanosterol glycosides from the bulbs of Muscari paradoxum. | Ori, K., et al. 2003. Phytochemistry. 64: 1351-9. PMID: 14629999
- Lanosterol and cholesterol-induced variations in bilayer elasticity probed by 2H NMR relaxation. | Martinez, GV., et al. 2004. Langmuir. 20: 1043-6. PMID: 15803674
- Friedelin and lanosterol from Garcinia prainiana stimulated glucose uptake and adipocytes differentiation in 3T3-L1 adipocytes. | Susanti, D., et al. 2013. Nat Prod Res. 27: 417-24. PMID: 22988818
- Lanosterol influences cytoplasmic maturation of pig oocytes in vitro and improves preimplantation development of cloned embryos. | Lee, S., et al. 2016. Theriogenology. 85: 575-84. PMID: 26494176
- Increased lanosterol turnover: a metabolic burden for daunorubicin-resistant leukemia cells. | Stäubert, C., et al. 2016. Med Oncol. 33: 6. PMID: 26698156
- Differential effects of cholesterol and lanosterol on artificial membranes. | Yeagle, PL., et al. 1977. Proc Natl Acad Sci U S A. 74: 4924-6. PMID: 270726
- Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages. | Araldi, E., et al. 2017. Cell Rep. 19: 2743-2755. PMID: 28658622
- Separation and purification of lanosterol, dihydrolanosterol, and cholesterol from lanolin by high-performance counter-current chromatography dual-mode elution method. | Pei, H., et al. 2019. J Sep Sci. 42: 2171-2178. PMID: 30950563
- The Intravitreal Injection of Lanosterol Nanoparticles Rescues Lens Structure Collapse at an Early Stage in Shumiya Cataract Rats. | Nagai, N., et al. 2020. Int J Mol Sci. 21: PMID: 32033321
- Bioinspired Synthesis of Spirochensilide A from Lanosterol. | Long, X., et al. 2022. J Am Chem Soc. 144: 16292-16297. PMID: 36054904
- Yeast Sec14-like lipid transfer proteins Pdr16 and Pdr17 bind and transfer the ergosterol precursor lanosterol in addition to phosphatidylinositol. | Šťastný, D., et al. 2023. FEBS Lett. 597: 504-514. PMID: 36482167
- Ergosterol and lanosterol from Aspergillus nidulans. | Shapiro, BE. and Gealt, MA. 1982. J Gen Microbiol. 128: 1053-6. PMID: 7050295
Activator of:
βA2-crystallin, βA4-crystallin, γA-crystallin, 1700019N19Rik, DHCR7, EBP, ORP-7_Osbpl7, Phakinin, SCAP, and TM7SF2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lanosterol, 1 mg | sc-215229 | 1 mg | $103.00 | |||
Lanosterol, 5 mg | sc-215229A | 5 mg | $343.00 |