Molecular structure of L-Mimosine, CAS Number: 500-44-7
L-Mimosine (CAS 500-44-7)
See product citations (8)
Alternate Names:
Leucenol
Application:
L-Mimosine is a rare plant non-protein toxic amino acid
CAS Number:
500-44-7
Purity:
≥98%
Molecular Weight:
198.18
Molecular Formula:
C8H10N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-Mimosine is a rare plant non-protein amino acid, chemically similar to tyrosine. It is a toxic amino acid, arresting the development of cells at the G1 phase. The synthesis of the amino acid hypusine by deoxyhypusyl hydroxylase is blocked by L-Mimosine hypusine is necessary for the function of eIF-5A (eukaryotic initiation factor 5A), and inhibition of its synthesis leads to suspension of the cell cycle. L-Mimosine is an inhibitor of DBH, eIF5A and Tyrosinase.
L-Mimosine (CAS 500-44-7) References
- The structure of leucenol; synthesis of 2,5-dihydroxy pyridine (5-hydroxy-2-pyridone). | ADAMS, R. and GOVINDACHARI, TR. 1947. J Am Chem Soc. 69: 1806-8. PMID: 20251424
- Effects of mimosine on Wolbachia in mosquito cells: cell cycle suppression reduces bacterial abundance. | Fallon, AM. 2015. In Vitro Cell Dev Biol Anim. 51: 958-63. PMID: 26019119
- Epigenetic Changes during Hepatic Stellate Cell Activation. | Götze, S., et al. 2015. PLoS One. 10: e0128745. PMID: 26065684
- L‑mimosine induces caspase‑9‑mediated apoptosis in human osteosarcoma cells. | Xu, Y. and Cai, L. 2018. Mol Med Rep. 17: 4695-4701. PMID: 29328422
- The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model. | Wertman, JN., et al. 2020. Elife. 9: PMID: 32720645
- Molecular Characterization of Advanced Colorectal Cancer Using Serum Proteomics and Metabolomics. | Rao, J., et al. 2021. Front Mol Biosci. 8: 687229. PMID: 34386520
- Investigation of β-Substitution Activity of O-Acetylserine Sulfhydrolase from Citrullus vulgaris. | Smith, JL., et al. 2022. Chembiochem. 23: e202200157. PMID: 35476889
- Calcitriol potentially alters HeLa cell viability via inhibition of autophagy. | Setiawan, I., et al. 2022. J Cancer Res Ther. 18: 1144-1151. PMID: 36149174
- In vitro rumen degradability of tropical legumes and their secondary metabolites depends on inoculum source. | Artiles-Ortega, E., et al. 2022. Trop Anim Health Prod. 54: 330. PMID: 36173493
- Hypoxia-inducible factor 1α enhances RANKL-induced osteoclast differentiation by upregulating the MAPK pathway. | Wang, D., et al. 2022. Ann Transl Med. 10: 1227. PMID: 36544674
- Potential immunomodulatory response associated with L-mimosine in male Wistar rats. | Hueza, IM., et al. 2023. Toxicon. 226: 107084. PMID: 36905965
- Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation. | Hanauske-Abel, HM., et al. 1994. Biochim Biophys Acta. 1221: 115-24. PMID: 8148388
- Mimosine arrests the cell cycle after cells enter S-phase. | Hughes, TA. and Cook, PR. 1996. Exp Cell Res. 222: 275-80. PMID: 8598214
Inhibitor of:
2810408P10Rik, ABCB7, AI481877, ASPHD2, BOLA2, CAF-1 p150, Cdc25A, COL11A2, Collagen Type IV, CRTAP, CUTC, CYBRD1, DBH, EG434729, eIF5A, fibrillin-2, FIH-1, HAH1, HARS2, HELIC1, HIF PHD, HIF PHD3, hSNF2H, INO80B, IRP-1, IRP-2, ISCA1/1L, ISCA2, Isw1p, JMJD2C, KRTAP21-3, Krtap28-10, KRTAP4-8, LEPREL1, LEPREL2, MCAF2, mito293Tndrial ferritin, Mitoferrin, MTF-1, NFU1, NLP, NRAMP2, Obox6, OGFOD2, OGFOD3, OTTMUSG00000016694, PCDHGC5, PH-4, PHD (peptidyl-proline 4-dioxygenase), PRODH, PSRC2, PYROXD1, Rad24, RhBG, RPA 34 kDa subunit, Rsf-1, scc-112_Pds5a, SF4, SH3TC2, TDRD5, THAP2, TIFAB, TRIP, TSPYL6, Tyrosinase, TYW1, VibH, Zfp871, ZIP5, and ZNF256.Activator of:
ADAR3, ANKZF1, ARL3, ASCC1, AUNIP, CCDC76, Cdc25C, Cdc6, CDCA2, CDKN2AIP, Chfr, CNOT1, COL20A1, COMMD8, COPT2, CPSF3L, CRM1, Cup1, cyclin F, cyclin H, DDX26B, DDX42, DDX46, DUB3, Dun1, E2F-4, E2F-7, E2F-8, E430018J23Rik, Epo, ESCO2, Esp1, FAM96A, FGF-1, G3BP2, Gap 1, Geminin, Hbb-y, Hemoglobin α, HIF-1 alpha, HIGD1B, HIGD1C, Histone H3F3C, IdnK, INO80C, KIAA0586, KIAA1618, LOC100041244, MCM9, Nek8, NHPX, NOL55, ORC2_Orc2, ORC3, ORC6, OTUB1, P4H-TM, PGs5, PIGF, PlGF2, POLA2, REPIN1, Ribosomal Protein L24, Rnr1, Rootletin, RPA16, Septin 1, SKIV2L, Slfn11, Ssn6, String, SUMO-2, TAF5L, Timeless, UNC84A, USP51, Wee 1, and ZCWCC1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Mimosine, 25 mg | sc-201536A | 25 mg | $35.00 | |||
L-Mimosine, 100 mg | sc-201536B | 100 mg | $86.00 | |||
L-Mimosine, 500 mg | sc-201536 | 500 mg | $216.00 | |||
L-Mimosine, 1 g | sc-201536C | 1 g | $427.00 |