Date published: 2026-2-28

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L-Glutamic acid monosodium salt monohydrate (CAS 6106-04-3)

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Alternate Names:
Monosodium glutamate monohydrate; MSG; Sodium L-Glutamate Monohydrate
CAS Number:
6106-04-3
Purity:
≥98%
Molecular Weight:
187.13
Molecular Formula:
C5H8NNaO4•H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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L-Glutamic acid monosodium salt monohydrate functions as a neurotransmitter in the central nervous system, playing a key role in excitatory synaptic transmission. It acts as an agonist at glutamate receptors, specifically the NMDA and AMPA receptors, leading to the depolarization of postsynaptic neurons. This chemical also serves as a precursor for the synthesis of GABA, an inhibitory neurotransmitter, through the action of the enzyme glutamate decarboxylase. Additionally, L-Glutamic acid monosodium salt monohydrate is involved in the citric acid cycle, serving as an intermediate in the metabolism of carbohydrates and amino acids. Its mode of action involves binding to specific receptors and enzymes, leading to the modulation of neuronal activity and the regulation of metabolic processes within the cell.


L-Glutamic acid monosodium salt monohydrate (CAS 6106-04-3) References

  1. Sensitive period in flavor learning: effects of duration of exposure to formula flavors on food likes during infancy.  |  Mennella, JA. and Castor, SM. 2012. Clin Nutr. 31: 1022-5. PMID: 22652361
  2. Direct UV determination of Amadori compounds using ligand-exchange and sweeping capillary electrophoresis.  |  Yu, J., et al. 2016. Anal Bioanal Chem. 408: 1657-66. PMID: 26790873
  3. A G326E substitution in the glutamate-gated chloride channel 3 (GluCl3) of the two-spotted spider mite Tetranychus urticae abolishes the agonistic activity of macrocyclic lactones.  |  Mermans, C., et al. 2017. Pest Manag Sci. 73: 2413-2418. PMID: 28736919
  4. Effect of semen extenders and storage time on quality of Muscovy duck (Cairina moschata) drake semen during the entire reproductive season.  |  Łukaszewicz, E., et al. 2020. Reprod Domest Anim. 55: 943-950. PMID: 32452061
  5. Safety and efficacy of monosodium l-glutamate monohydrate produced by Corynebacterium glutamicum KCCM 80188 as a feed additive for all animal species.  |  ,., et al. 2020. EFSA J. 18: e06085. PMID: 32874293
  6. Selective Modification for Red-Shifted Excitability: A Small Change in Structure, a Huge Change in Photochemistry.  |  Becker, Y., et al. 2021. Chemistry. 27: 2212-2218. PMID: 32955154
  7. MONOSODIUM GLUTAMATE (E621) AND ITS EFFECT ON THE GASTROINTESTINAL ORGANS (REVIEW).  |  Yachmin, A., et al. 2021. Georgian Med News. 147-151. PMID: 34749341
  8. Safety and efficacy of a feed additive consisting of monosodium l-glutamate produced by fermentation with Corynebacterium glutamicum KCCM 80187 for all animal species (CJ Europe GmbH).  |  ,., et al. 2021. EFSA J. 19: e06982. PMID: 34934460
  9. Temperature effect on calcium binding to aspartate and glutamate.  |  Liu, XC., et al. 2022. Food Res Int. 159: 111625. PMID: 35940812
  10. Production of polyglutamic acid-like mucilage protein by Peribacillus simplex strain 8h.  |  Sato, S., et al. 2023. Folia Microbiol (Praha). 68: 101-113. PMID: 35947243
  11. Quantitative Application of in Situ ATR-FTIR and Raman Spectroscopy in Crystallization Processes  |  Jeroen Cornel, Christian Lindenberg, and Marco Mazzotti*. 2008. Ind. Eng. Chem. Res., 47, 14,: 4870–4882.
  12. Experimental Characterization and Population Balance Modeling of the Polymorph Transformation of l-Glutamic Acid  |  Jeroen Cornel†, Christian Lindenberg†, and Marco Mazzotti*. 2009,. Cryst. Growth Des. 9, 1,: 243–252.
  13. Receptor Regulation in Taste: Can Diet Influence How We Perceive Foods?  |  by Ashkan A. Shahbandi, et al. 2018. J., 1(1),: 106-115;.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

L-Glutamic acid monosodium salt monohydrate, 250 g

sc-250218
250 g
$38.00

L-Glutamic acid monosodium salt monohydrate, 1 kg

sc-250218A
1 kg
$72.00

L-Glutamic acid monosodium salt monohydrate, 5 kg

sc-250218B
5 kg
$260.00