Isoxanthohumol (CAS 521-48-2)
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Isoxanthohumol is a prenylflavonoid found in hops, known for its role in the brewing industry, and is the subject of interest in various research fields, including food science and biochemistry. Studies involving isoxanthohumol are centered on its potential as an antioxidant and its behavior during the brewing process, which can influence the taste and quality of beer. In biochemical research, isoxanthohumol is used to investigate its interactions with biological molecules and its transformation into other compounds under physiological conditions. Researchers also use this compound to understand its effects on enzyme activity, specifically those involved in oxidation-reduction processes. Furthermore, isoxanthohumol is studied for its role in modulating gene expression, which is valuable for understanding the mechanisms by which certain dietary components can influence cellular functions. It is also a focus in the investigation of the bioavailability and metabolism of flavonoids in human nutrition.
Isoxanthohumol (CAS 521-48-2) References
- The prenylflavonoid phytoestrogens 8-prenylnaringenin and isoxanthohumol diferentially suppress steroidogenesis in rat Leydig cells in ontogenesis. | Izzo, G., et al. 2011. J Appl Toxicol. 31: 589-94. PMID: 21061451
- Isoxanthohumol--Biologically active hop flavonoid. | Żołnierczyk, AK., et al. 2015. Fitoterapia. 103: 71-82. PMID: 25771121
- Enantiospecific pharmacokinetics of isoxanthohumol and its metabolite 8-prenylnaringenin in the rat. | Martinez, SE. and Davies, NM. 2015. Mol Nutr Food Res. 59: 1674-89. PMID: 26079861
- Versatile antitumor potential of isoxanthohumol: Enhancement of paclitaxel activity in vivo. | Krajnović, T., et al. 2016. Pharmacol Res. 105: 62-73. PMID: 26784390
- Prenylflavonoid Isoxanthohumol Sensitizes MCF-7/ADR Cells to Doxorubicin Cytotoxicity via Acting as a Substrate of ABCB1. | Liu, M., et al. 2017. Toxins (Basel). 9: PMID: 28665335
- Chiral separation of isoxanthohumol and 8-prenylnaringenin in beer, hop pellets and hops by HPLC with chiral columns. | Moriya, H., et al. 2018. Biomed Chromatogr. 32: e4289. PMID: 29768665
- Isoxanthohumol stimulates ubiquitin-proteasome-dependent degradation of precursor forms of sterol regulatory element-binding proteins. | Inoue, J., et al. 2018. Biosci Biotechnol Biochem. 82: 1591-1598. PMID: 29804513
- Biotransformed Metabolites of the Hop Prenylflavanone Isoxanthohumol. | Kim, HJ., et al. 2019. Molecules. 24: PMID: 30678278
- Biotransformation of a major beer prenylflavonoid - isoxanthohumol. | Bartmańska, A., et al. 2018. Z Naturforsch C J Biosci. 74: 1-7. PMID: 30864390
- The hop-derived prenylflavonoid isoxanthohumol inhibits the formation of lung metastasis in B16-F10 murine melanoma model. | Krajnović, T., et al. 2019. Food Chem Toxicol. 129: 257-268. PMID: 31034931
- Isoxanthohumol, a hop-derived flavonoid, alters the metabolomics profile of mouse feces. | Fukizawa, S., et al. 2020. Biosci Microbiota Food Health. 39: 100-108. PMID: 32775127
- The Antifungal Mechanism of Isoxanthohumol from Humulus lupulus Linn. | Yan, YF., et al. 2021. Int J Mol Sci. 22: PMID: 34639194
- Isoxanthohumol, a component of Sophora flavescens, promotes the activation of the NLRP3 inflammasome and induces idiosyncratic hepatotoxicity. | Lin, L., et al. 2022. J Ethnopharmacol. 285: 114796. PMID: 34740771
- Anticancer Potential of Xanthohumol and Isoxanthohumol Loaded into SBA-15 Mesoporous Silica Particles against B16F10 Melanoma Cells. | Krajnović, T., et al. 2022. Materials (Basel). 15: PMID: 35888494
- Norkurarinone and isoxanthohumol inhibit high glucose and hypoxia-induced angiogenesis via improving oxidative stress and regulating autophagy in human retinal microvascular endothelial cells. | Zhao, K., et al. 2022. Biochem Biophys Res Commun. 634: 20-29. PMID: 36228541
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Isoxanthohumol, 1 mg | sc-221771 | 1 mg | $68.00 |