Inosine (CAS 58-63-9)
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Inosine, a vital nucleoside present in all living organisms, holds significant importance in various biological research domains. Serving as a purine nucleoside, it is an essential constituent of the genetic code. Inosine plays a pivotal role in nucleic acid synthesis and contributes to gene expression regulation. Its versatile applications encompass diverse scientific research areas. In vitro studies have shed light on the role of inosine in examining nucleic acid functions associated with gene expression regulation and cancer progression. Furthermore, Inosine has contributed significantly to exploring the biochemical and physiological impacts of nucleic acids. As a purine nucleoside, Inosine binds to the ribosome, the site of protein synthesis, and serves as a template for mRNA synthesis. Additionally, Inosine interacts with DNA acting as a template for DNA synthesis. Moreover, it binds to RNA, which constitutes the cell′s genetic material, and facilitates protein synthesis.
Inosine (CAS 58-63-9) References
- Inosine infusion prevents mortality in endotoxic shock. | Darlington, DN. and Gann, DS. 2005. J Trauma. 59: 1432-5; discussion 1435. PMID: 16394918
- Protective effects of inosine on mice subjected to lethal total-body ionizing irradiation. | Hou, B., et al. 2007. J Radiat Res. 48: 57-62. PMID: 17179648
- Adenosine and inosine exert cytoprotective effects in an in vitro model of liver ischemia-reperfusion injury. | Módis, K., et al. 2013. Int J Mol Med. 31: 437-46. PMID: 23232950
- The antidepressant-like effect of inosine in the FST is associated with both adenosine A1 and A 2A receptors. | Kaster, MP., et al. 2013. Purinergic Signal. 9: 481-6. PMID: 23613131
- Transcriptome-wide identification of adenosine-to-inosine editing using the ICE-seq method. | Suzuki, T., et al. 2015. Nat Protoc. 10: 715-32. PMID: 25855956
- Mechanisms involved in the antinociception induced by spinal administration of inosine or guanine in mice. | de Oliveira, ED., et al. 2016. Eur J Pharmacol. 772: 71-82. PMID: 26712379
- The filamentous fungus Ashbya gossypii as a competitive industrial inosine producer. | Ledesma-Amaro, R., et al. 2016. Biotechnol Bioeng. 113: 2060-3. PMID: 26927228
- Signaling pathways underlying the antidepressant-like effect of inosine in mice. | Gonçalves, FM., et al. 2017. Purinergic Signal. 13: 203-214. PMID: 27966087
- Methods for the Detection of Adenosine-to-Inosine Editing Events in Cellular RNA. | Oakes, E., et al. 2017. Methods Mol Biol. 1648: 103-127. PMID: 28766293
- Inosine RNA modifications are enriched at the codon wobble position in mouse oocytes and eggs†. | Brachova, P., et al. 2019. Biol Reprod. 101: 938-949. PMID: 31346607
- Identification of Adenosine-to-Inosine RNA Editing with Acrylonitrile Reagents. | Li, Y., et al. 2019. Org Lett. 21: 7948-7951. PMID: 31516001
- Inosine Substitutions in RNA Activate Latent G-Quadruplexes. | Hagen, T., et al. 2021. J Am Chem Soc. 143: 15120-15130. PMID: 34520206
- Investigating the Effect of Inosine on Brain Purinergic Receptors and Neurotrophic and Neuroinflammatory Parameters in an Experimental Model of Alzheimer's Disease. | Teixeira, FC., et al. 2022. Mol Neurobiol. 59: 841-855. PMID: 34792730
- Inosine : a naturally occurring cardiotonic agent. | Aviado, DM. 1983. J Pharmacol. 14 Suppl 3: 47-71. PMID: 6368998
- Inosine: alternative or adjunct to regional hypothermia in the prevention of post-ischemic renal failure? | Marberger, M., et al. 1980. Eur Urol. 6: 95-102. PMID: 7358066
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Inosine, 1 g | sc-295182 | 1 g | $59.00 | |||
Inosine, 5 g | sc-295182A | 5 g | $90.00 |