Molecular structure of Ginkgolide B, CAS Number: 15291-77-7
Ginkgolide B (CAS 15291-77-7)
See product citations (8)
Alternate Names:
Ginkolide B; BN 52021
Application:
Ginkgolide B is a potent PAF-R antagonist
CAS Number:
15291-77-7
Purity:
≥90%
Molecular Weight:
424.40
Molecular Formula:
C20H24O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ginkgolide B is a terpene lactone compound found in Ginkgo biloba and is recognized for its biological activity in scientific research. In studies, Ginkgolide B is particularly noted for its ability to act as a potent antagonist of platelet-activating factor (PAF), thereby making it a point of focus in research on blood flow and clotting mechanisms. Researchers utilize Ginkgolide B to explore its potential effects on cognitive function, as well as its influence on neuroprotective mechanisms due to its reported ability to modulate neurotransmitter pathways. Additionally, its role in the protection against oxidative stress is of interest when investigating cellular defense mechanisms against free radical damage. Ginkgolide B is also studied for its potential impact on inflammatory responses, where it may modulate various signaling molecules and pathways.
Ginkgolide B (CAS 15291-77-7) References
- Ginkgolides and bilobalide: their physical, chromatographic and spectroscopic properties. | van Beek, TA. 2005. Bioorg Med Chem. 13: 5001-12. PMID: 15993092
- Platelet-activating factor primes neutrophil responses to agonists: role in promoting neutrophil-mediated endothelial damage. | Vercellotti, GM., et al. 1988. Blood. 71: 1100-7. PMID: 2451547
- Comparison of three paf-acether receptor antagonist ginkgolides. | Korth, R., et al. 1988. Eur J Pharmacol. 152: 101-10. PMID: 2850196
- Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig. | Desquand, S., et al. 1986. Eur J Pharmacol. 127: 83-95. PMID: 3019727
- Effects of platelet activating factor on the chemotaxis of normodense eosinophils from normal subjects. | Tamura, N., et al. 1987. Biochem Biophys Res Commun. 142: 638-44. PMID: 3030295
- Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988. | Nunez, D., et al. 1986. Eur J Pharmacol. 123: 197-205. PMID: 3086108
- Study on the attenuated effect of Ginkgolide B on ferroptosis in high fat diet induced nonalcoholic fatty liver disease. | Yang, Y., et al. 2020. Toxicology. 445: 152599. PMID: 32976958
- Ginkgolide B promotes oligodendrocyte precursor cell differentiation and survival via Akt/CREB/bcl-2 signaling pathway after white matter lesion. | Huang, J., et al. 2021. Exp Biol Med (Maywood). 246: 1198-1209. PMID: 33557607
- Ginkgolide B monotherapy reverses osteoporosis by regulating oxidative stress-mediated bone homeostasis. | Lee, CW., et al. 2021. Free Radic Biol Med. 168: 234-246. PMID: 33781894
- Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer's disease. | Shao, L., et al. 2022. Metab Brain Dis. 37: 329-341. PMID: 35050445
- Ginkgolide B targets and inhibits creatine kinase B to regulate the CCT/TRiC-SK1 axis and exerts pro-angiogenic activity in middle cerebral artery occlusion mice. | Zhu, J., et al. 2022. Pharmacol Res. 180: 106240. PMID: 35513225
- Identification of metabolites of Ginkgolide B in vivo and in vitro using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. | Zhang, X., et al. 2022. J Sep Sci. 45: 2458-2477. PMID: 35543088
- Ginkgolide B Protects Against Ischemic Stroke via Targeting AMPK/PINK1. | Cao, Y., et al. 2022. Front Pharmacol. 13: 941094. PMID: 35837278
- Ginkgolide B improved postoperative cognitive dysfunction by inhibiting microgliosis-mediated neuroinflammation in the hippocampus of mice. | Luo, T., et al. 2022. BMC Anesthesiol. 22: 229. PMID: 35850641
- Ginkgolide B alleviates oxidative stress and ferroptosis by inhibiting GPX4 ubiquitination to improve diabetic nephropathy. | Chen, J., et al. 2022. Biomed Pharmacother. 156: 113953. PMID: 36411664
Inhibitor of:
2610005M20Rik, LMP7, OATP-C, OATP8, PAF-R, PAFAH1B2, PAFAH1B3, PC-PLD2C, PhyC, Prestin, TEX264, and V1RC25.Activator of:
ε Tubulin, 2610005M20Rik, Cerebellin 4, ChemR23, claudin-5, cystatin C, DnaJC5B, eIF2Bγ, EPX, GALR2, GAP-43, Munc13-1, OR4N5, PAF acetylhydrolase 2, PAF-R, Pax-2, SENP8, SRP54, Syntaxin 1, TMC1, Uroguanylin, Vmn1r161, and Vmn1r169.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ginkgolide B, 5 mg | sc-201037B | 5 mg | $45.00 | |||
Ginkgolide B, 10 mg | sc-201037 | 10 mg | $63.00 | |||
Ginkgolide B, 25 mg | sc-201037C | 25 mg | $112.00 | |||
Ginkgolide B, 50 mg | sc-201037A | 50 mg | $197.00 |