Gambogic Acid (CAS 2752-65-0)
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Gambogic acid is a natural product that has gained attention in biochemical research due to its activity as a potent apoptosis inducer. It is frequently used in studies focused on the intrinsic mitochondrial pathway of apoptosis, where gambogic acid may act to disrupt the mitochondrial membrane potential. The research involving gambogic acid primarily centers on its binding affinity to transferrin receptor proteins, which are often overexpressed in cancer cells, thereby providing a mechanism to explore the selective induction of cell death. Additionally, its role in the generation of reactive oxygen species (ROS) and the subsequent activation of apoptotic pathways is a subject of interest. In cellular models, gambogic acid is also used to investigate its influence on various signaling cascades, including the NF-κB pathway, which is known to regulate a wide array of genes involved in immune and inflammatory responses.
Gambogic Acid (CAS 2752-65-0) References
- Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay. | Zhang, HZ., et al. 2004. Bioorg Med Chem. 12: 309-17. PMID: 14723951
- Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells. | Zhao, L., et al. 2004. Biol Pharm Bull. 27: 998-1003. PMID: 15256729
- A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid. | Kasibhatla, S., et al. 2005. Proc Natl Acad Sci U S A. 102: 12095-100. PMID: 16103367
- Preparation, physical properties, and stability of gambogic acid-loaded micelles based on chitosan derivatives. | Zhu, X., et al. 2008. Drug Dev Ind Pharm. 34: 2-9. PMID: 18214750
- Mechanisms of gambogic acid-induced apoptosis in non-small cell lung cancer cells in relation to transferrin receptors. | Zhu, X., et al. 2009. J Chemother. 21: 666-72. PMID: 20071291
- Enhancement of anticancer efficacy of chemotherapeutics by gambogic acid against gastric cancer cells. | Zou, ZY., et al. 2012. Cancer Biother Radiopharm. 27: 299-306. PMID: 22444164
- Synergistic anti-proliferative effects of gambogic acid with docetaxel in gastrointestinal cancer cell lines. | Zou, Z., et al. 2012. BMC Complement Altern Med. 12: 58. PMID: 22546220
- Daunorubicin and gambogic acid coloaded cysteamine-CdTe quantum dots minimizing the multidrug resistance of lymphoma in vitro and in vivo. | Zhou, Y., et al. 2016. Int J Nanomedicine. 11: 5429-5442. PMID: 27799767
- Global profiling of cellular targets of gambogic acid by quantitative chemical proteomics. | Zhou, Y., et al. 2016. Chem Commun (Camb). 52: 14035-14038. PMID: 27853763
- Gambogic Acid Induces Apoptosis of Non-Small Cell Lung Cancer (NSCLC) Cells by Suppressing Notch Signaling. | Zhu, M., et al. 2018. Med Sci Monit. 24: 7146-7151. PMID: 30293083
- Gambogic Acid Shows Anti-Proliferative Effects on Non-Small Cell Lung Cancer (NSCLC) Cells by Activating Reactive Oxygen Species (ROS)-Induced Endoplasmic Reticulum (ER) Stress-Mediated Apoptosis. | Zhu, M., et al. 2019. Med Sci Monit. 25: 3983-3988. PMID: 31138775
- Gambogic acid suppresses colon cancer cell activity in vitro. | Zhou, Z. and Ma, J. 2019. Exp Ther Med. 18: 2917-2923. PMID: 31555380
- Gambogic acid suppresses the pentose phosphate pathway by covalently inhibiting 6PGD protein in cancer cells. | Zhu, Y., et al. 2022. Chem Commun (Camb). 58: 9030-9033. PMID: 35876000
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gambogic Acid, 5 mg | sc-200137 | 5 mg | $85.00 | |||
Gambogic Acid, 25 mg | sc-200137A | 25 mg | $243.00 | |||
Gambogic Acid, 100 mg | sc-200137B | 100 mg | $419.00 | |||
Gambogic Acid, 500 mg | sc-200137C | 500 mg | $720.00 | |||
Gambogic Acid, 1 g | sc-200137D | 1 g | $1230.00 |