Date published: 2025-11-20

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(−)-Gallocatechin (CAS 3371-27-5)

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Alternate Names:
(2S,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol
Application:
(−)-Gallocatechin is an antioxidant found in green tea
CAS Number:
3371-27-5
Purity:
≥95%
Molecular Weight:
306.27
Molecular Formula:
C15H14O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(−)-Gallocatechin is a compound that functions as a potent antioxidant in experimental applications. It exerts its mechanism of action by scavenging free radicals and preventing oxidative damage to cells and biomolecules. At the molecular level, (−)-Gallocatechin interacts with reactive oxygen species, neutralizing their harmful effects and protecting cellular components from oxidative stress. (−)-Gallocatechin also demonstrates the ability to modulate various signaling pathways involved in oxidative stress response, contributing to its antioxidant properties. Through its molecular interactions, (−)-Gallocatechin plays a role in maintaining cellular homeostasis and protecting against oxidative damage in experimental models. Its mechanism of action involves direct interactions with reactive oxygen species and indirect modulation of cellular signaling pathways, highlighting its functional role as an antioxidant in experimental applications.j


(−)-Gallocatechin (CAS 3371-27-5) References

  1. ESR study on the structure-antioxidant activity relationship of tea catechins and their epimers.  |  Guo, Q., et al. 1999. Biochim Biophys Acta. 1427: 13-23. PMID: 10082983
  2. Heat-epimerized tea catechins rich in gallocatechin gallate and catechin gallate are more effective to inhibit cholesterol absorption than tea catechins rich in epigallocatechin gallate and epicatechin gallate.  |  Ikeda, I., et al. 2003. J Agric Food Chem. 51: 7303-7. PMID: 14640575
  3. Anti-cariogenic effects of polyphenols from plant stimulant beverages (cocoa, coffee, tea).  |  Ferrazzano, GF., et al. 2009. Fitoterapia. 80: 255-62. PMID: 19397954
  4. Polyphenol content of plasma and litter after the oral administration of green tea and tea polyphenols in chickens.  |  Zhou, YB., et al. 2012. J Agric Food Chem. 60: 1619-27. PMID: 22224899
  5. Validation of a mass spectrometry method to quantify oak ellagitannins in wine samples.  |  García-Estévez, I., et al. 2012. J Agric Food Chem. 60: 1373-9. PMID: 22268581
  6. Biotransformation of (-)-epigallocatechin and (-)-gallocatechin by intestinal bacteria involved in isoflavone metabolism.  |  Takagaki, A. and Nanjo, F. 2015. Biol Pharm Bull. 38: 325-30. PMID: 25747993
  7. Protein Surface Structural Recognition in Inactive Areas: A New Immobilization Strategy for Acetylcholinesterase.  |  Diao, J., et al. 2018. Bioconjug Chem. 29: 1703-1713. PMID: 29617563
  8. β-Cyclodextrin encapsulation elevates antioxidant capacity of tea: A closing chapter on non-epicatechins, atomistic insights from X-ray analysis, DFT calculation and DPPH assay.  |  Aree, T. and Jongrungruangchok, S. 2018. Carbohydr Polym. 194: 24-33. PMID: 29801835
  9. Taxifolin Resensitizes Multidrug Resistance Cancer Cells via Uncompetitive Inhibition of P-Glycoprotein Function.  |  Chen, HJ., et al. 2018. Molecules. 23: PMID: 30469543
  10. Development of HPLC Method for Catechins and Related Compounds Determination and Standardization in Miang (Traditional Lanna Fermented Tea Leaf in Northern Thailand).  |  Wangkarn, S., et al. 2021. Molecules. 26: PMID: 34641598
  11. Green tea aqueous extract (GTAE) prevents high-fat diet-induced obesity by activating fat browning.  |  Li, J., et al. 2021. Food Sci Nutr. 9: 6548-6558. PMID: 34925784
  12. High-Resolution Bioassay Profiling with Complemented Sensitivity and Resolution for Pancreatic Lipase Inhibitor Screening.  |  Jian, J., et al. 2022. Molecules. 27: PMID: 36296516
  13. Inhibitory effects of green tea polyphenols on growth and cellular adherence of an oral bacterium, Porphyromonas gingivalis.  |  Sakanaka, S., et al. 1996. Biosci Biotechnol Biochem. 60: 745-9. PMID: 8704303

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(−)-Gallocatechin, 1 mg

sc-252848
1 mg
$74.00

(−)-Gallocatechin, 5 mg

sc-252848A
5 mg
$304.00

(−)-Gallocatechin, 10 mg

sc-252848B
10 mg
$551.00

(−)-Gallocatechin, 50 mg

sc-252848C
50 mg
$1632.00

(−)-Gallocatechin, 100 mg

sc-252848D
100 mg
$2856.00

Hi, With the 1mg unit - is the 1mg mass accurate or is it a minimal of of 1mg in the bottle? Best Sunmeet

Asked by: Sunmeet
With the 1 mg unit it is a minimal of 1 mg in the bottle.
Answered by: Technical Service
Date published: 2023-12-18

What is is the % purity of compound (-)-Gallocatechin (CAS 3371-27-5) with catalog number sc-252848?

Asked by: danish
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot.
Answered by: Technical Support
Date published: 2019-01-26
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Rated 5 out of 5 by from ChuChu, KO. et al. (PubMed 26362107) investigated the effects of (-)-Gallocatechin (EGCG) on pharmacokinetics, oxidative status and expression of inflammatory and apoptotic genes in the rat ocular tissues. Found that low level of EGCG can provide short-term anti-oxidative and anti-apoptotic effect without affecting ocular immunity to the normal retina. -SCBT Publication Review
Date published: 2015-03-21
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(−)-Gallocatechin is rated 5.0 out of 5 by 1.
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