Date published: 2025-11-20

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Fusaric acid (CAS 536-69-6)

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Alternate Names:
5-Butylpyridine-2-carboxylic acid
Application:
Fusaric acid is an inhibitor of dopamine β-hydroxylase
CAS Number:
536-69-6
Purity:
≥98%
Molecular Weight:
179.22
Molecular Formula:
C10H13NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Fusaric acid is a small molecule inhibitor of DBH (dopamine beta-hydroxylase), an enzyme responsible for the conversion of dopamine to norepinephrine. Reports indicate that Fusaric acid exposure will decrease levels of norepinephrine while slightly increasing levels of dopamine in the brain. Serotonin levels are affected by the respective levels of dopamine and norepinephrine, and a slight increase in serotonin level has also been correlated with Fusaric acid activity. Fusaric acid is also observed to induce inhibition of dopamine and norepinephrine synaptosomal uptake. Fusaric acid, a naturally existing organic compound, is present in various fungal species such as Aspergillus, Fusarium, and Penicillium. This compound exhibits remarkable inhibitory properties against chitinase, an enzyme responsible for breaking down chitin—a vital constituent of fungal cell walls.


Fusaric acid (CAS 536-69-6) References

  1. Pharmacological activities of fusaric acid (5-butylpicolinic acid).  |  Wang, H. and Ng, TB. 1999. Life Sci. 65: 849-56. PMID: 10465344
  2. Pharmacological action of FD-008, a new dopamine-beta-hydroxylase inhibitor. III. Effects on endogenous biogenic amine levels in rats.  |  Ishii, Y., et al. 1975. Arzneimittelforschung. 25: 383-5. PMID: 1174036
  3. Fusaric acid, a mycotoxin, and its influence on blood coagulation and platelet function.  |  Devaraja, S., et al. 2013. Blood Coagul Fibrinolysis. 24: 419-23. PMID: 23343693
  4. Fusaric acid and analogues as Gram-negative bacterial quorum sensing inhibitors.  |  Tung, TT., et al. 2017. Eur J Med Chem. 126: 1011-1020. PMID: 28033578
  5. Detoxification of Fusaric Acid by the Soil Microbe Mucor rouxii.  |  Crutcher, FK., et al. 2017. J Agric Food Chem. 65: 4989-4992. PMID: 28538103
  6. Fusaric acid alters Akt and ampk signalling in c57bl/6 mice brain tissue.  |  Dhani, S., et al. 2020. Food Chem Toxicol. 138: 111252. PMID: 32156565
  7. Fusaric acid induces hepatic global m6A RNA methylation and differential expression of m6A regulatory genes in vivo - a pilot study.  |  Ghazi, T., et al. 2022. Epigenetics. 17: 695-703. PMID: 34517792
  8. Fusaric acid detoxification: a strategy of Gliocladium roseum involved in its antagonism against Fusarium verticillioides.  |  Kuang, Y., et al. 2022. Mycotoxin Res. 38: 13-25. PMID: 35023019
  9. The Fusaric Acid Derivative qy17 Inhibits Staphylococcus haemolyticus by Disrupting Biofilm Formation and the Stress Response via Altered Gene Expression.  |  Wang, B., et al. 2022. Front Microbiol. 13: 822148. PMID: 35369527
  10. The psychological effects of dopamine-beta-hydroxylase inhibition in normal subjects.  |  Hartmann, E. and Keller-Teschke, M. 1979. Biol Psychiatry. 14: 455-62. PMID: 476231
  11. Fusaric (5-butylpicolinic) acid, an inhibitor of dopamine beta-hydroxylase, affects serotonin and noradrenaline.  |  Hidaka, H. 1971. Nature. 231: 54-5. PMID: 4930475
  12. Interaction at the synaptic level of fusaric acid with neurotransmitters.  |  Fischer, HD., et al. 1980. Acta Biol Med Ger. 39: 935-40. PMID: 7282224
  13. Fusaric acid and pathogenic interactions of corn and non-corn isolates of Fusarium moniliforme, a nonobligate pathogen of corn.  |  Bacon, CW. and Hinton, DM. 1996. Adv Exp Med Biol. 392: 175-91. PMID: 8850616

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fusaric acid, 50 mg

sc-202616
50 mg
$44.00

Fusaric acid, 250 mg

sc-202616A
250 mg
$107.00

Fusaric acid, 1 g

sc-202616B
1 g
$301.00